KCNK6: Difference between revisions

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{{Infobox_gene}}
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'''Potassium channel subfamily K member 6''' is a [[protein]] that in humans is encoded by the ''KCNK6'' [[gene]].<ref name="pmid10075682">{{cite journal |vauthors=Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS | title = TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family | journal = J Biol Chem | volume = 274 | issue = 12 | pages = 7887–92 |date=Apr 1999 | pmid = 10075682 | pmc =  | doi =10.1074/jbc.274.12.7887 }}</ref><ref name="pmid10393428">{{cite journal |vauthors=Gray AT, Kindler CH, Sampson ER, Yost CS | title = Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 84 | issue = 3–4 | pages = 190–1 |date=Jul 1999 | pmid = 10393428 | pmc = | doi =10.1159/000015255  }}</ref><ref name="pmid16382106">{{cite journal |vauthors=Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S | title = International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 527–40 |date=Dec 2005 | pmid = 16382106 | pmc =  | doi = 10.1124/pr.57.4.12 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNK6 potassium channel, subfamily K, member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9424| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium channel, subfamily K, member 6
| HGNCid = 6281
| Symbol = KCNK6
| AltSymbols =; FLJ12282; K2p6.1; KCNK8; TOSS; TWIK-2; TWIK2
| OMIM = 603939
| ECnumber =
| Homologene = 31266
| MGIid = 1891291
  | GeneAtlas_image1 = PBB_GE_KCNK6_gnf1h00063_at_tn.png
  | Function = {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9424
    | Hs_Ensembl = ENSG00000099337
    | Hs_RefseqProtein = NP_004814
    | Hs_RefseqmRNA = NM_004823
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 43502322
    | Hs_GenLoc_end = 43511480
    | Hs_Uniprot = Q9Y257
    | Mm_EntrezGene = 52150
    | Mm_Ensembl = ENSMUSG00000046410
    | Mm_RefseqmRNA = XM_993219
    | Mm_RefseqProtein = XP_998313
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 28930688
    | Mm_GenLoc_end = 28941253
    | Mm_Uniprot = 
  }}
}}
'''Potassium channel, subfamily K, member 6''', also known as '''KCNK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNK6 potassium channel, subfamily K, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9424| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.<ref name="entrez">{{cite web | title = Entrez Gene: KCNK6 potassium channel, subfamily K, member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9424| accessdate = }}</ref>
| summary_text = This gene encodes '''K<sub>2P</sub>6.1''', one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K<sub>2P</sub>6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175-84 |year= 2001 |pmid= 11256078 |doi=  }}
*{{cite journal  |vauthors=Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N |title=Potassium leak channels and the KCNK family of two-P-domain subunits |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 175–84 |year= 2001 |pmid= 11256078 |doi=10.1038/35058574  }}
*{{cite journal  | author=Goldstein SA, Bayliss DA, Kim D, ''et al.'' |title=International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 527-40 |year= 2006 |pmid= 16382106 |doi= 10.1124/pr.57.4.12 }}
*{{cite journal  |vauthors=Mahboubi S, Kaufmann JH |title=Intramural duodenal hematoma in children.  The role of the radiologist in its conservative management |journal=Gastrointestinal radiology |volume=1 |issue= 2 |pages= 167–71 |year= 1978 |pmid= 1088718 |doi=  }}
*{{cite journal  | author=Mahboubi S, Kaufmann JH |title=Intramural duodenal hematoma in children.  The role of the radiologist in its conservative management. |journal=Gastrointestinal radiology |volume=1 |issue= 2 |pages= 167-71 |year= 1978 |pmid= 1088718 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | author=Salinas M |title=Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11751–60 |year= 1999 |pmid= 10206991 |doi=10.1074/jbc.274.17.11751  |name-list-format=vanc| author2=Reyes R  | author3=Lesage F  | display-authors=3  | last4=Fosset  | first4=M  | last5=Heurteaux  | first5=C  | last6=Romey  | first6=G  | last7=Lazdunski  | first7=M }}
*{{cite journal | author=Chavez RA, Gray AT, Zhao BB, ''et al.'' |title=TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7887-92 |year= 1999 |pmid= 10075682 |doi=  }}
*{{cite journal  | author=Pountney DJ |title=Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit |journal=FEBS Lett. |volume=450 |issue= 3 |pages= 191–6 |year= 1999 |pmid= 10359073 |doi=10.1016/S0014-5793(99)00495-0  |name-list-format=vanc| author2=Gulkarov I  | author3=Vega-Saenz de Miera E  | display-authors=3 | last4=Holmes | first4=D  | last5=Saganich  | first5=M  | last6=Rudy  | first6=B  | last7=Artman  | first7=M  | last8=Coetzee  | first8=WA }}
*{{cite journal  | author=Salinas M, Reyes R, Lesage F, ''et al.'' |title=Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11751-60 |year= 1999 |pmid= 10206991 |doi=  }}
*{{cite journal  | author=Patel AJ |title=TWIK-2, an inactivating 2P domain K+ channel |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28722–30 |year= 2000 |pmid= 10887187 |doi= 10.1074/jbc.M003755200 |name-list-format=vanc| author2=Maingret F  | author3=Magnone V  | display-authors=3  | last4=Fosset  | first4=M  | last5=Lazdunski  | first5=M  | last6=Honoré  | first6=E }}
*{{cite journal  | author=Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, ''et al.'' |title=Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit. |journal=FEBS Lett. |volume=450 |issue= 3 |pages= 191-6 |year= 1999 |pmid= 10359073 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Gray AT, Kindler CH, Sampson ER, Yost CS |title=Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 190-1 |year= 1999 |pmid= 10393428 |doi=  }}
*{{cite journal  | author=Mhatre AN |title=Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4 |journal=J. Neurosci. Res. |volume=75 |issue= 1 |pages= 25–31 |year= 2004 |pmid= 14689445 |doi= 10.1002/jnr.10839 |name-list-format=vanc| author2=Li J  | author3=Chen AF  | display-authors=3  | last4=Yost  | first4=C. Spencer  | last5=Smith  | first5=Richard J.H.  | last6=Kindler  | first6=Christoph H.  | last7=Lalwani  | first7=Anil K. }}
*{{cite journal  | author=Patel AJ, Maingret F, Magnone V, ''et al.'' |title=TWIK-2, an inactivating 2P domain K+ channel. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28722-30 |year= 2000 |pmid= 10887187 |doi= 10.1074/jbc.M003755200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Mhatre AN, Li J, Chen AF, ''et al.'' |title=Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4. |journal=J. Neurosci. Res. |volume=75 |issue= 1 |pages= 25-31 |year= 2004 |pmid= 14689445 |doi= 10.1002/jnr.10839 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|KCNK6+protein,+human}}
* {{MeshName|KCNK6+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 06:16, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[1][2][3][4]

This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[4]

See also

References

  1. ↑ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682.
  2. ↑ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428.
  3. ↑ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  4. ↑ 4.0 4.1 "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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