Methylpentynol: Difference between revisions
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'''Methylpentynol''' ('''Methylparafynol''', '''Dormison''', '''Atemorin''') is a [[Alcohol#tertiary|tertiary]] [[hexanol]] with [[hypnotic]]/[[sedative]] and [[anticonvulsant]] effects. It was discovered by Bayer in 1913<ref>{{ cite patent | country = DE | status = patent | number = 289800 | gdate = 1913-11-30 | assign1 = Bayer, Leverkusen | title = Verfahren zur Darstellung der Oxyalkylderivate von Kohlenwasserstoffen }}</ref> and was used shortly thereafter for the treatment of [[insomnia]], but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.<ref>{{ cite pmid | 14903452 }}</ref><ref>{{cite pmid | 13028241 }}</ref><ref>{{ cite pmid | 13159700 }}</ref><ref>{{ cite pmid | 13783544 }}</ref> | '''Methylpentynol''' ('''Methylparafynol''', '''Dormison''', '''Atemorin''') is a [[Alcohol#tertiary|tertiary]] [[hexanol]] with [[hypnotic]]/[[sedative]] and [[anticonvulsant]] effects. It was discovered by Bayer in 1913<ref>{{ cite patent | country = DE | status = patent | number = 289800 | gdate = 1913-11-30 | assign1 = Bayer, Leverkusen | title = Verfahren zur Darstellung der Oxyalkylderivate von Kohlenwasserstoffen }}</ref> and was used shortly thereafter for the treatment of [[insomnia]], but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.<ref>{{ cite pmid | 14903452 }}</ref><ref>{{cite pmid | 13028241 }}</ref><ref>{{ cite pmid | 13159700 }}</ref><ref>{{ cite pmid | 13783544 }}</ref> | ||
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Revision as of 19:43, 9 April 2015
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| Trade names | Oblivon |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C6H10O |
| Molar mass | 98.143 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Methylpentynol (Methylparafynol, Dormison, Atemorin) is a tertiary hexanol with hypnotic/sedative and anticonvulsant effects. It was discovered by Bayer in 1913[1] and was used shortly thereafter for the treatment of insomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.[2][3][4][5]
To make meparfynol proper, the alcohol must be reacted with phosgene followed by ammonia to form the carbamate (see patent). Also, ethynylation of cyclohexanone is one of the preferred analogs
References
- ↑ DE patent 289800, "Verfahren zur Darstellung der Oxyalkylderivate von Kohlenwasserstoffen", issued 1913-11-30, assigned to Bayer, Leverkusen
- ↑ PMID 14903452 (PMID 14903452)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 13028241 (PMID 13028241)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 13159700 (PMID 13159700)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 13783544 (PMID 13783544)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
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- Anticonvulsants
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