Janus kinase 1: Difference between revisions

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{{Infobox_gene}}
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'''JAK1''' is a human [[tyrosine kinase]] protein essential for signaling for certain type I and type II [[cytokine]]s.  It interacts with the common gamma chain (γc) of [[type I cytokine receptor]]s, to elicit signals from the [[IL-2 receptor|IL-2]] receptor family (e.g. [[IL-2 receptor|IL-2R]], [[Interleukin 7|IL-7R]], [[Interleukin 9|IL-9R]] and [[Interleukin 15|IL-15R]]), the [[Interleukin-4|IL-4]] receptor family (e.g. [[Interleukin-4|IL-4R]] and [[Interleukin 13|IL-13R]]), the [[gp130]] receptor family (e.g. [[interleukin-6|IL-6R]], [[interleukin-11|IL-11R]], [[Leukemia inhibitory factor|LIF-R]], [[Oncostatin M|OSM-R]], [[cardiotrophin-1]] receptor (CT-1R), [[ciliary neurotrophic factor]] receptor (CNTF-R), [[neurotrophin-1]] receptor (NNT-1R) and [[Leptin]]-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) [[interferon]]s, and members of the [[Interleukin 10|IL-10]] family via [[type II cytokine receptor]]s.<ref name="pmid11406370">{{cite journal |vauthors=Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ |title=Signaling by type I and II cytokine receptors: ten years after |journal=Curr. Opin. Immunol. |volume=13 |issue=3 |pages=363–73 |year=2001 |pmid=11406370 |doi=10.1016/S0952-7915(00)00228-4}}</ref>  Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.<ref name="pmid9590172">{{cite journal |vauthors=Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD |title=Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses |journal=Cell |volume=93 |issue=3 |pages=373–83 |year=1998 |pmid=9590172 |doi=10.1016/S0092-8674(00)81166-6}}</ref> Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and [[metastasize]] to other parts of the body.<ref>{{cite news |title=Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor |author=Christian Nordqvist|url = http://www.medicalnewstoday.com/articles/232761.php | publisher = ''Medical News Today''}}</ref>
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==Interactions==
{{GNF_Protein_box
Janus kinase 1 has been shown to [[Protein-protein interaction|interact]] with:
| image =
{{div col|colwidth=20em}}
| image_source =
* [[ELP2]],<ref name = pmid10954736>{{cite journal | date = August 2000 |vauthors=Collum RG, Brutsaert S, Lee G, Schindler C | title = A Stat3-interacting protein (StIP1) regulates cytokine signal transduction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 18 | pages = 10120–5 | pmid = 10954736 | pmc = 27739 | doi = 10.1073/pnas.170192197}}</ref>
| PDB =  
* [[GNB2L1]]<ref name = pmid12960323>{{cite journal | date = September 2003 |vauthors=Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR | title = The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex | journal = J. Immunol. | volume = 171 | issue = 6 | pages = 2989–94 | pmid = 12960323 | doi = 10.4049/jimmunol.171.6.2989}}</ref>
| Name = Janus kinase 1 (a protein tyrosine kinase)
* [[Glycoprotein 130|IL6ST]],<ref name = pmid11468294>{{cite journal | date = October 2001 |vauthors=Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I | title = Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction | journal = J. Biol. Chem. | volume = 276 | issue = 40 | pages = 37451–8 | pmid = 11468294 | doi = 10.1074/jbc.M106135200}}</ref><ref name = pmid9388212>{{cite journal | date = December 1997 |vauthors=Kim H, Baumann H | title = Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells | journal = J. Biol. Chem. | volume = 272 | issue = 49 | pages = 30741–7 | pmid = 9388212 | doi = 10.1074/jbc.272.49.30741}}</ref><ref name = pmid11742534>{{cite journal | date = January 2002 |vauthors=Haan C, Heinrich PC, Behrmann I | title = Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation | journal = Biochem. J. | volume = 361 | issue = Pt 1 | pages = 105–11 | pmid = 11742534 | pmc = 1222284 | doi = 10.1042/0264-6021:3610105}}</ref>
| HGNCid = 6190
* [[Grb2]],<ref name = pmid11527382>{{cite journal | date = September 2001 |vauthors=Kim H, Lee YH, Won J, Yun Y | title = Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers | journal = Biochem. Biophys. Res. Commun. | volume = 286 | issue = 5 | pages = 886–94 | pmid = 11527382 | doi = 10.1006/bbrc.2001.5496}}</ref><ref name = pmid8536716>{{cite journal | date = December 1995 |vauthors=Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E | title = Involvement of Janus kinases in the insulin signaling pathway | journal = Eur. J. Biochem. | volume = 234 | issue = 2 | pages = 656–60 | pmid = 8536716 | doi = 10.1111/j.1432-1033.1995.656_b.x}}</ref>
| Symbol = JAK1
* [[IL2RB]],<ref name = pmid12133952/><ref name = pmid7973659>{{cite journal | date = November 1994 |vauthors=Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN | title = Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits | journal = Science | volume = 266 | issue = 5187 | pages = 1045–7 | pmid = 7973659 | doi = 10.1126/science.7973659}}</ref><ref name = pmid7973658>{{cite journal | date = November 1994 |vauthors=Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O | title = Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID | journal = Science | volume = 266 | issue = 5187 | pages = 1042–5 | pmid = 7973658 | doi = 10.1126/science.7973658}}</ref><ref name = pmid9553136>{{cite journal | date = April 1998 |vauthors=Zhu MH, Berry JA, Russell SM, Leonard WJ | title = Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta | journal = J. Biol. Chem. | volume = 273 | issue = 17 | pages = 10719–25 | pmid = 9553136 | doi = 10.1074/jbc.273.17.10719}}</ref><ref name = pmid9774657>{{cite journal | date = November 1998 |vauthors=Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ | title = Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation | journal = Mol. Cell. Biol. | volume = 18 | issue = 11 | pages = 6416–22 | pmid = 9774657 | pmc = 109227 | doi = 10.1128/mcb.18.11.6416}}</ref>
| AltSymbols =; JAK1A; JAK1B
* [[IRS1]],<ref name = pmid9492017>{{cite journal | date = March 1998 |vauthors=Gual P, Baron V, Lequoy V, Van Obberghen E | title = Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor | journal = Endocrinology | volume = 139 | issue = 3 | pages = 884–93 | pmid = 9492017 | doi = 10.1210/endo.139.3.5829}}</ref><ref name = pmid7499365>{{cite journal | date = December 1995 |vauthors=Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ | title = Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases | journal = J. Biol. Chem. | volume = 270 | issue = 48 | pages = 28527–30 | pmid = 7499365 | doi = 10.1074/jbc.270.48.28527}}</ref>
| OMIM = 147795
* [[Interleukin 10 receptor, alpha subunit|IL10RA]],<ref name = pmid12133952>{{cite journal | date = August 2002 |vauthors=Usacheva A, Kotenko S, Witte MM, Colamonici OR | title = Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors | journal = J. Immunol. | volume = 169 | issue = 3 | pages = 1302–8 | pmid = 12133952 | doi = 10.4049/jimmunol.169.3.1302}}</ref><ref name = pmid12374810>{{cite journal | date = December 2002 |vauthors=Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR | title = Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation | journal = J. Biol. Chem. | volume = 277 | issue = 50 | pages = 48220–6 | pmid = 12374810 | doi = 10.1074/jbc.M205757200}}</ref>
| ECnumber =
* [[PTPN11]],<ref name = pmid8995399>{{cite journal | date = January 1997 |vauthors=Yin T, Shen R, Feng GS, Yang YC | title = Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases | journal = J. Biol. Chem. | volume = 272 | issue = 2 | pages = 1032–7 | pmid = 8995399 | doi = 10.1074/jbc.272.2.1032}}</ref><ref name = pmid12403768>{{cite journal | date = January 2003 |vauthors=Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F | title = SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 | journal = J. Biol. Chem. | volume = 278 | issue = 1 | pages = 661–71 | pmid = 12403768 | doi = 10.1074/jbc.M210552200}}</ref>
| Homologene = 1678
* [[STAM2]],<ref name = pmid10993906>{{cite journal | date = December 2000 |vauthors=Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF | title = Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways | journal = J. Biol. Chem. | volume = 275 | issue = 49 | pages = 38633–9 | pmid = 10993906 | doi = 10.1074/jbc.M007849200}}</ref><ref name = pmid10899310>{{cite journal | date = July 2000 |vauthors=Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K | title = STAM2, a new member of the STAM family, binding to the Janus kinases | journal = FEBS Lett. | volume = 477 | issue = 1-2 | pages = 55–61 | pmid = 10899310 | doi = 10.1016/s0014-5793(00)01760-9}}</ref>
| MGIid = 96628
* [[STAT3]],<ref name = pmid11751884>{{cite journal | date = March 2002 |vauthors=Ueda T, Bruchovsky N, Sadar MD | title = Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7076–85 | pmid = 11751884 | doi = 10.1074/jbc.M108255200}}</ref><ref name = pmid11722592>{{cite journal | date = August 2001 |vauthors=Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F | title = Constitutive activation of STAT transcription factors in acute myelogenous leukemia | journal = Eur. J. Haematol. | volume = 67 | issue = 2 | pages = 63–71 | pmid = 11722592 | doi = 10.1034/j.1600-0609.2001.t01-1-00385.x}}</ref>
| GeneAtlas_image1 = PBB_GE_JAK1_201648_at_tn.png
* [[STAT5A]],<ref name = pmid9047382>{{cite journal | date = February 1997 |vauthors=Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T | title = An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT | journal = Oncogene | volume = 14 | issue = 7 | pages = 751–61 | pmid = 9047382 | doi = 10.1038/sj.onc.1200907}}</ref>
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004718 |text = Janus kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}  
* [[STAT5B]],<ref name = pmid9047382/>  and
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}  
* [[TNFRSF1A]].<ref name = pmid9510175>{{cite journal | date = March 1998 |vauthors=Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB | title = Induction of Jak/STAT signaling by activation of the type 1 TNF receptor | journal = J. Immunol. | volume = 160 | issue = 6 | pages = 2742–50 | pmid = 9510175 | doi = }}</ref><ref name = pmid11801527>{{cite journal | date = January 2002 |vauthors=Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A | title = Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells | journal = Cell Growth Differ. | volume = 13 | issue = 1 | pages = 13–8 | pmid = 11801527 | doi = }}</ref>  
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}  
{{Div col end}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3716
    | Hs_Ensembl = ENSG00000162434
    | Hs_RefseqProtein = NP_002218
    | Hs_RefseqmRNA = NM_002227
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 65071500
    | Hs_GenLoc_end = 65204775
    | Hs_Uniprot = P23458
    | Mm_EntrezGene = 16451
    | Mm_Ensembl = ENSMUSG00000028530
    | Mm_RefseqmRNA = NM_146145
    | Mm_RefseqProtein = NP_666257
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 100650299
    | Mm_GenLoc_end = 100763214
    | Mm_Uniprot = Q3TI10
  }}
}}
'''JAK1''' is essential for signaling for certain type I and type II [[cytokine]]s.  It interacts with the common gamma chain (γc) of [[type I cytokine receptor]]s, to elicit signals from the [[IL-2]] receptor family (e.g. [[IL-2 receptor|IL-2R]], [[IL-7]]R, [[IL-9]]R and [[IL-15]]R), the [[IL-4]] receptor family (e.g. [[IL-4]]R and [[IL-13]]R), the [[gp130]] receptor family (e.g. [[interleukin-6|IL-6R]], [[interleukin-11|IL-11R]], [[Leukemia inhibitory factor|LIF-R]], [[Oncostatin M|OSM-R]], [[cardiotrophin-1]] receptor (CT-1R), [[ciliary neurotrophic factor]] receptor (CNTF-R), [[neurotrophin-1]] receptor (NNT-1R) and [[Leptin]]-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) [[interferon]]s, and members of the [[IL-10]] family via [[type II cytokine receptor]]s.<ref name="pmid11406370">{{cite journal |author=Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ |title=Signaling by type I and II cytokine receptors: ten years after |journal=Curr. Opin. Immunol. |volume=13 |issue=3 |pages=363-73 |year=2001 |pmid=11406370 |doi=}}</ref> Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.<ref name="pmid9590172">{{cite journal |author=Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD |title=Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses |journal=Cell |volume=93 |issue=3 |pages=373-83 |year=1998 |pmid=9590172 |doi=}}</ref>


==References==
==References==
<div class="references-small">
{{reflist}}
{{reflist|2}}
</div>


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Donnelly RP, Dickensheets H, Finbloom DS |title=The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. |journal=J. Interferon Cytokine Res. |volume=19 |issue= 6 |pages= 563-73 |year= 1999 |pmid= 10433356 |doi= 10.1089/107999099313695 }}
*{{cite journal  |vauthors=Donnelly RP, Dickensheets H, Finbloom DS |title=The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes |journal=J. Interferon Cytokine Res. |volume=19 |issue= 6 |pages= 563–73 |year= 1999 |pmid= 10433356 |doi= 10.1089/107999099313695 }}
*{{cite journal  | author=Carter-Su C, Rui L, Stofega MR |title=SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. |journal=Recent Prog. Horm. Res. |volume=55 |issue=  |pages= 293-311 |year= 2000 |pmid= 11036942 |doi=  }}
*{{cite journal  |vauthors=Carter-Su C, Rui L, Stofega MR |title=SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone |journal=Recent Prog. Horm. Res. |volume=55 |issue=  |pages= 293–311 |year= 2000 |pmid= 11036942 |doi=  }}
*{{cite journal  | author=Kostrodymova GM |title=[An experimental study of the possible sensitizing properties of triethanolamine contained in chemical compounds used at home] |journal=Gigiena i sanitariia |volume= |issue= 6 |pages= 10-2 |year= 1976 |pmid= 1213395 |doi=  }}
*{{cite journal  | author=Kostrodymova GM |title=[An experimental study of the possible sensitizing properties of triethanolamine contained in chemical compounds used at home] |journal=Gigiena i sanitariia |volume= |issue= 6 |pages= 10–2 |year= 1976 |pmid= 1213395 |doi=  }}
*{{cite journal  | author=Howard OM, Dean M, Young H, ''et al.'' |title=Characterization of a class 3 tyrosine kinase. |journal=Oncogene |volume=7 |issue= 5 |pages= 895-900 |year= 1992 |pmid= 1373877 |doi=  }}
*{{cite journal  | author=Howard OM |title=Characterization of a class 3 tyrosine kinase |journal=Oncogene |volume=7 |issue= 5 |pages= 895–900 |year= 1992 |pmid= 1373877 |doi=  |name-list-format=vanc| author2=Dean M  | author3=Young H  | display-authors=3 | last4=Ramsburg  | first4=M  | last5=Turpin  | first5=JA  | last6=Michiel  | first6=DF  | last7=Kelvin | first7=DJ | last8=Lee  | first8=L  | last9=Farrar  | first9=WL  }}
*{{cite journal  | author=Pritchard MA, Baker E, Callen DF, ''et al.'' |title=Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24. |journal=Mamm. Genome |volume=3 |issue= 1 |pages= 36-8 |year= 1992 |pmid= 1581631 |doi=  }}
*{{cite journal  | author=Pritchard MA |title=Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24 |journal=Mamm. Genome |volume=3 |issue= 1 |pages= 36–8 |year= 1992 |pmid= 1581631 |doi=10.1007/BF00355839 |name-list-format=vanc| author2=Baker E  | author3=Callen DF  | display-authors=3  | last4=Sutherland  | first4=Grant R. | last5=Wilks  | first5=Andrew F.  }}
*{{cite journal | author=Wilks AF, Harpur AG, Kurban RR, ''et al.'' |title=Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 2057-65 |year= 1991 |pmid= 1848670 |doi=  }}
*{{cite journal  | author=Wilks AF |title=Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 2057–65 |year= 1991 |pmid= 1848670 |doi=  | pmc=359893 |name-list-format=vanc| author2=Harpur AG  | author3=Kurban RR  | display-authors=3 | last4=Ralph  | first4=SJ  | last5=Zürcher  | first5=G  | last6=Ziemiecki  | first6=A }}
*{{cite journal  | author=Johnston JA, Wang LM, Hanson EP, ''et al.'' |title=Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28527-30 |year= 1996 |pmid= 7499365 |doi= }}
*{{cite journal  | author=Johnston JA |title=Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28527–30 |year= 1996 |pmid= 7499365 |doi=10.1074/jbc.270.48.28527 |name-list-format=vanc| author2=Wang LM  | author3=Hanson EP  | display-authors=3  | last4=Sun  | first4=XJ  | last5=White  | first5=MF  | last6=Oakes  | first6=SA  | last7=Pierce  | first7=JH  | last8=O'Shea  | first8=JJ  }}
*{{cite journal | author=Nicholson SE, Oates AC, Harpur AG, ''et al.'' |title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2985-8 |year= 1994 |pmid= 7512720 |doi=  }}
*{{cite journal  | author=Nicholson SE |title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2985–8 |year= 1994 |pmid= 7512720 |doi=10.1073/pnas.91.8.2985 | pmc=43499 |name-list-format=vanc| author2=Oates AC  | author3=Harpur AG  | display-authors=3  | last4=Ziemiecki  | first4=A  | last5=Wilks  | first5=AF  | last6=Layton  | first6=JE }}
*{{cite journal  | author=Domanski P, Yan H, Witte MM, ''et al.'' |title=Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. |journal=FEBS Lett. |volume=374 |issue= 3 |pages= 317-22 |year= 1995 |pmid= 7589562 |doi=  }}
*{{cite journal  | author=Domanski P |title=Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase |journal=FEBS Lett. |volume=374 |issue= 3 |pages= 317–22 |year= 1995 |pmid= 7589562 |doi=10.1016/0014-5793(95)01094-U |name-list-format=vanc| author2=Yan H | author3=Witte MM  | display-authors=3  | last4=Krolewski  | first4=J  | last5=Colamonici  | first5=OR  }}
*{{cite journal | author=Modi WS, Farrar WL, Howard OM |title=Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3-->p31.3 by nonisotopic in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 232-4 |year= 1995 |pmid= 7698020 |doi=  }}
*{{cite journal  |vauthors=Modi WS, Farrar WL, Howard OM |title=Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3→p31.3 by nonisotopic in situ hybridization |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3–4 |pages= 232–4 |year= 1995 |pmid= 7698020 |doi=10.1159/000133971 }}
*{{cite journal  | author=Miyazaki T, Kawahara A, Fujii H, ''et al.'' |title=Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. |journal=Science |volume=266 |issue= 5187 |pages= 1045-7 |year= 1994 |pmid= 7973659 |doi=  }}
*{{cite journal  | author=Miyazaki T |title=Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits |journal=Science |volume=266 |issue= 5187 |pages= 1045–7 |year= 1994 |pmid= 7973659 |doi=10.1126/science.7973659 |name-list-format=vanc| author2=Kawahara A | author3=Fujii H  | display-authors=3  | last4=Nakagawa  | first4=Y  | last5=Minami  | first5=Y  | last6=Liu  | first6=Z. | last7=Oishi  | first7=I  | last8=Silvennoinen  | first8=O  | last9=Witthuhn  | first9=B. }}
*{{cite journal  | author=Müller M, Briscoe J, Laxton C, ''et al.'' |title=The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. |journal=Nature |volume=366 |issue= 6451 |pages= 129-35 |year= 1993 |pmid= 8232552 |doi= 10.1038/366129a0 }}
*{{cite journal  | author=Müller M |title=The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction |journal=Nature |volume=366 |issue= 6451 |pages= 129–35 |year= 1993 |pmid= 8232552 |doi= 10.1038/366129a0  |name-list-format=vanc| author2=Briscoe J  | author3=Laxton C  | display-authors=3  | last4=Guschin  | first4=Dmitry  | last5=Ziemiecki  | first5=Andrew  | last6=Silvennoinen  | first6=Olli  | last7=Harpur  | first7=Ailsa G.  | last8=Barbieri  | first8=Giovanna  | last9=Witthuhn  | first9=Bruce A. }}
*{{cite journal  | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403-10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal  |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal | author=Lütticken C, Wegenka UM, Yuan J, ''et al.'' |title=Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. |journal=Science |volume=263 |issue= 5143 |pages= 89-92 |year= 1994 |pmid= 8272872 |doi=  }}
*{{cite journal  | author=Lütticken C |title=Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 |journal=Science |volume=263 |issue= 5143 |pages= 89–92 |year= 1994 |pmid= 8272872 |doi=10.1126/science.8272872  |name-list-format=vanc| author2=Wegenka UM  | author3=Yuan J  | display-authors=3  | last4=Buschmann  | first4=J  | last5=Schindler  | first5=C  | last6=Ziemiecki  | first6=A  | last7=Harpur  | first7=A.  | last8=Wilks  | first8=A.  | last9=Yasukawa  | first9=K  }}
*{{cite journal  | author=Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E |title=Involvement of Janus kinases in the insulin signaling pathway. |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 656-60 |year= 1996 |pmid= 8536716 |doi=  }}
*{{cite journal  |vauthors=Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E |title=Involvement of Janus kinases in the insulin signaling pathway |journal=Eur. J. Biochem. |volume=234 |issue= 2 |pages= 656–60 |year= 1996 |pmid= 8536716 |doi=10.1111/j.1432-1033.1995.656_b.x  }}
*{{cite journal | author=Friedmann MC, Migone TS, Russell SM, Leonard WJ |title=Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 2077-82 |year= 1996 |pmid= 8700888 |doi=  }}
*{{cite journal  |vauthors=Friedmann MC, Migone TS, Russell SM, Leonard WJ |title=Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 2077–82 |year= 1996 |pmid= 8700888 |doi=10.1073/pnas.93.5.2077  | pmc=39912  }}
*{{cite journal  | author=Gauzzi MC, Velazquez L, McKendry R, ''et al.'' |title=Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20494-500 |year= 1996 |pmid= 8702790 |doi=  }}
*{{cite journal  | author=Gauzzi MC |title=Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20494–500 |year= 1996 |pmid= 8702790 |doi=10.1074/jbc.271.34.20494  |name-list-format=vanc| author2=Velazquez L  | author3=McKendry R  | display-authors=3  | last4=Mogensen  | first4=KE  | last5=Fellous  | first5=M  | last6=Pellegrini  | first6=S  }}
*{{cite journal | author=Demoulin JB, Uyttenhove C, Van Roost E, ''et al.'' |title=A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4710-6 |year= 1996 |pmid= 8756628 |doi=  }}
*{{cite journal  | author=Demoulin JB |title=A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4710–6 |year= 1996 |pmid= 8756628 |doi=  | pmc=231471  |name-list-format=vanc| author2=Uyttenhove C  | author3=Van Roost E  | display-authors=3  | last4=Delestré  | first4=B  | last5=Donckers  | first5=D  | last6=Van Snick  | first6=J  | last7=Renauld  | first7=JC  }}
*{{cite journal  | author=Yin T, Shen R, Feng GS, Yang YC |title=Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1032-7 |year= 1997 |pmid= 8995399 |doi=  }}
*{{cite journal  |vauthors=Yin T, Shen R, Feng GS, Yang YC |title=Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1032–7 |year= 1997 |pmid= 8995399 |doi=10.1074/jbc.272.2.1032 }}
*{{cite journal  | author=Bluyssen HA, Levy DE |title=Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4600-5 |year= 1997 |pmid= 9020188 |doi=  }}
*{{cite journal  |vauthors=Bluyssen HA, Levy DE |title=Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4600–5 |year= 1997 |pmid= 9020188 |doi=10.1074/jbc.272.7.4600 }}
}}
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{{JAK-STAT signaling pathway}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Cytokine receptor modulators}}
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{{Tyrosine kinases}}
[[Category:Tyrosine kinases]]
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Latest revision as of 15:14, 30 July 2016

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Orthologs
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JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors.[1] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.[2] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.[3]

Interactions

Janus kinase 1 has been shown to interact with:

References

  1. ↑ Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001). "Signaling by type I and II cytokine receptors: ten years after". Curr. Opin. Immunol. 13 (3): 363–73. doi:10.1016/S0952-7915(00)00228-4. PMID 11406370.
  2. ↑ Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD (1998). "Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses". Cell. 93 (3): 373–83. doi:10.1016/S0092-8674(00)81166-6. PMID 9590172.
  3. ↑ Christian Nordqvist. "Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor". Medical News Today.
  4. ↑ Collum RG, Brutsaert S, Lee G, Schindler C (August 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10120–5. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
  5. ↑ Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR (September 2003). "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. Immunol. 171 (6): 2989–94. doi:10.4049/jimmunol.171.6.2989. PMID 12960323.
  6. ↑ Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I (October 2001). "Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction". J. Biol. Chem. 276 (40): 37451–8. doi:10.1074/jbc.M106135200. PMID 11468294.
  7. ↑ Kim H, Baumann H (December 1997). "Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells". J. Biol. Chem. 272 (49): 30741–7. doi:10.1074/jbc.272.49.30741. PMID 9388212.
  8. ↑ Haan C, Heinrich PC, Behrmann I (January 2002). "Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation". Biochem. J. 361 (Pt 1): 105–11. doi:10.1042/0264-6021:3610105. PMC 1222284. PMID 11742534.
  9. ↑ Kim H, Lee YH, Won J, Yun Y (September 2001). "Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers". Biochem. Biophys. Res. Commun. 286 (5): 886–94. doi:10.1006/bbrc.2001.5496. PMID 11527382.
  10. ↑ Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (December 1995). "Involvement of Janus kinases in the insulin signaling pathway". Eur. J. Biochem. 234 (2): 656–60. doi:10.1111/j.1432-1033.1995.656_b.x. PMID 8536716.
  11. ↑ 11.0 11.1 Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. doi:10.4049/jimmunol.169.3.1302. PMID 12133952.
  12. ↑ Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045–7. doi:10.1126/science.7973659. PMID 7973659.
  13. ↑ Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science. 266 (5187): 1042–5. doi:10.1126/science.7973658. PMID 7973658.
  14. ↑ Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta". J. Biol. Chem. 273 (17): 10719–25. doi:10.1074/jbc.273.17.10719. PMID 9553136.
  15. ↑ Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998). "Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation". Mol. Cell. Biol. 18 (11): 6416–22. doi:10.1128/mcb.18.11.6416. PMC 109227. PMID 9774657.
  16. ↑ Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998). "Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor". Endocrinology. 139 (3): 884–93. doi:10.1210/endo.139.3.5829. PMID 9492017.
  17. ↑ Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases". J. Biol. Chem. 270 (48): 28527–30. doi:10.1074/jbc.270.48.28527. PMID 7499365.
  18. ↑ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. 277 (50): 48220–6. doi:10.1074/jbc.M205757200. PMID 12374810.
  19. ↑ Yin T, Shen R, Feng GS, Yang YC (January 1997). "Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases". J. Biol. Chem. 272 (2): 1032–7. doi:10.1074/jbc.272.2.1032. PMID 8995399.
  20. ↑ Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130". J. Biol. Chem. 278 (1): 661–71. doi:10.1074/jbc.M210552200. PMID 12403768.
  21. ↑ Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (December 2000). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". J. Biol. Chem. 275 (49): 38633–9. doi:10.1074/jbc.M007849200. PMID 10993906.
  22. ↑ Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (July 2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Lett. 477 (1–2): 55–61. doi:10.1016/s0014-5793(00)01760-9. PMID 10899310.
  23. ↑ Ueda T, Bruchovsky N, Sadar MD (March 2002). "Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways". J. Biol. Chem. 277 (9): 7076–85. doi:10.1074/jbc.M108255200. PMID 11751884.
  24. ↑ Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". Eur. J. Haematol. 67 (2): 63–71. doi:10.1034/j.1600-0609.2001.t01-1-00385.x. PMID 11722592.
  25. ↑ 25.0 25.1 Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). "An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT". Oncogene. 14 (7): 751–61. doi:10.1038/sj.onc.1200907. PMID 9047382.
  26. ↑ Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998). "Induction of Jak/STAT signaling by activation of the type 1 TNF receptor". J. Immunol. 160 (6): 2742–50. PMID 9510175.
  27. ↑ Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A (January 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth Differ. 13 (1): 13–8. PMID 11801527.

Further reading

External links

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