GJA4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Gap junction alpha-4 protein''' is a [[protein]] that in humans is encoded by the ''GJA4'' [[gene]].<ref name="pmid9843209">{{cite journal |vauthors=Richard G, Smith LE, Bailey RA, Itin P, Hohl D, ((Epstein EH Jr)), DiGiovanna JJ, Compton JG, Bale SJ | title = Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis | journal = Nat Genet | volume = 20 | issue = 4 | pages = 366–9 |date=Dec 1998 | pmid = 9843209 | pmc =  | doi = 10.1038/3840 }}</ref><ref name="pmid7680674">{{cite journal |vauthors=Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC | title = Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein | journal = J Clin Invest | volume = 91 | issue = 3 | pages = 997–1004 |date=Apr 1993 | pmid = 7680674 | pmc = 288052 | doi = 10.1172/JCI116321 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2701| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Gap junction protein, alpha 4, 37kDa
| HGNCid = 4278
| Symbol = GJA4
| AltSymbols =; CX37
| OMIM = 121012
| ECnumber = 
| Homologene = 1556
| MGIid = 95715
| GeneAtlas_image1 = PBB_GE_GJA4_40687_at_tn.png
| GeneAtlas_image2 = PBB_GE_GJA4_204904_at_tn.png
| Function = {{GNF_GO|id=GO:0015285 |text = gap-junction channel activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005922 |text = connexon complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001568 |text = blood vessel development}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007043 |text = intercellular junction assembly}} {{GNF_GO|id=GO:0007154 |text = cell communication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2701
    | Hs_Ensembl = ENSG00000187513
    | Hs_RefseqProtein = NP_002051
    | Hs_RefseqmRNA = NM_002060
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 35031186
    | Hs_GenLoc_end = 35033935
    | Hs_Uniprot = P35212
    | Mm_EntrezGene = 14612
    | Mm_Ensembl = ENSMUSG00000050234
    | Mm_RefseqmRNA = NM_008120
    | Mm_RefseqProtein = NP_032146
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 126813725
    | Mm_GenLoc_end = 126816282
    | Mm_Uniprot = Q3UPZ2
  }}
}}
'''Gap junction protein, alpha 4, 37kDa''', also known as '''GJA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2701| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.<ref name="entrez">{{cite web | title = Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2701| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite book|author1=Andrew L Harris |author2=Darren Locke | title = Connexins, A Guide | publisher = Springer | year = 2009 | location = New York | pages = 574 | url = https://www.springer.com/978-1-934115-46-6  | isbn = 978-1-934115-46-6}}
| citations =  
*{{cite journal  |vauthors=Beyer EC, Paul DL, Goodenough DA |title=Connexin family of gap junction proteins |journal=J. Membr. Biol. |volume=116 |issue= 3 |pages= 187–94 |year= 1990 |pmid= 2167375 |doi=10.1007/BF01868459 }}
*{{cite journal  | author=Beyer EC, Paul DL, Goodenough DA |title=Connexin family of gap junction proteins. |journal=J. Membr. Biol. |volume=116 |issue= 3 |pages= 187-94 |year= 1990 |pmid= 2167375 |doi=  }}
*{{cite journal  |vauthors=Haefliger JA, Bruzzone R, Jenkins NA |title=Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 2057–64 |year= 1992 |pmid= 1370487 |doi=  |display-authors=etal}}
*{{cite journal  | author=Haefliger JA, Bruzzone R, Jenkins NA, ''et al.'' |title=Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 2057-64 |year= 1992 |pmid= 1370487 |doi=  }}
*{{cite journal  |vauthors=Risek B, Guthrie S, Kumar N, Gilula NB |title=Modulation of gap junction transcript and protein expression during pregnancy in the rat |journal=J. Cell Biol. |volume=110 |issue= 2 |pages= 269–82 |year= 1990 |pmid= 1688855 |doi=10.1083/jcb.110.2.269  | pmc=2116004 }}
*{{cite journal  | author=Risek B, Guthrie S, Kumar N, Gilula NB |title=Modulation of gap junction transcript and protein expression during pregnancy in the rat. |journal=J. Cell Biol. |volume=110 |issue= 2 |pages= 269-82 |year= 1990 |pmid= 1688855 |doi=  }}
*{{cite journal  |vauthors=Willecke K, Jungbluth S, Dahl E |title=Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes |journal=Eur. J. Cell Biol. |volume=53 |issue= 2 |pages= 275–80 |year= 1991 |pmid= 1964417 |doi=  |display-authors=etal}}
*{{cite journal  | author=Willecke K, Jungbluth S, Dahl E, ''et al.'' |title=Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes. |journal=Eur. J. Cell Biol. |volume=53 |issue= 2 |pages= 275-80 |year= 1991 |pmid= 1964417 |doi=  }}
*{{cite journal  |vauthors=Van Camp G, Coucke P, Speleman F |title=The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195 |journal=Genomics |volume=30 |issue= 2 |pages= 402–3 |year= 1996 |pmid= 8586454 |doi=  |display-authors=etal}}
*{{cite journal  | author=Reed KE, Westphale EM, Larson DM, ''et al.'' |title=Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. |journal=J. Clin. Invest. |volume=91 |issue= 3 |pages= 997-1004 |year= 1993 |pmid= 7680674 |doi=  }}
*{{cite journal  |vauthors=Krutovskikh V, Mironov N, Yamasaki H |title=Human connexin 37 is polymorphic but not mutated in tumours |journal=Carcinogenesis |volume=17 |issue= 8 |pages= 1761–3 |year= 1996 |pmid= 8761439 |doi=10.1093/carcin/17.8.1761 }}
*{{cite journal  | author=Van Camp G, Coucke P, Speleman F, ''et al.'' |title=The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195. |journal=Genomics |volume=30 |issue= 2 |pages= 402-3 |year= 1996 |pmid= 8586454 |doi=  }}
*{{cite journal  |vauthors=Simon AM, Goodenough DA, Li E, Paul DL |title=Female infertility in mice lacking connexin 37 |journal=Nature |volume=385 |issue= 6616 |pages= 525–9 |year= 1997 |pmid= 9020357 |doi= 10.1038/385525a0 }}
*{{cite journal  | author=Krutovskikh V, Mironov N, Yamasaki H |title=Human connexin 37 is polymorphic but not mutated in tumours. |journal=Carcinogenesis |volume=17 |issue= 8 |pages= 1761-3 |year= 1996 |pmid= 8761439 |doi=  }}
*{{cite journal  |vauthors=Krenacs T, Rosendaal M |title=Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation |journal=Am. J. Pathol. |volume=152 |issue= 4 |pages= 993–1004 |year= 1998 |pmid= 9546360 |doi= | pmc=1858239 }}
*{{cite journal  | author=Simon AM, Goodenough DA, Li E, Paul DL |title=Female infertility in mice lacking connexin 37. |journal=Nature |volume=385 |issue= 6616 |pages= 525-9 |year= 1997 |pmid= 9020357 |doi= 10.1038/385525a0 }}
*{{cite journal  |vauthors=van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ |title=Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells |journal=Cytokine |volume=10 |issue= 4 |pages= 258–64 |year= 1998 |pmid= 9617570 |doi= 10.1006/cyto.1997.0287 }}
*{{cite journal  | author=Krenacs T, Rosendaal M |title=Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation. |journal=Am. J. Pathol. |volume=152 |issue= 4 |pages= 993-1004 |year= 1998 |pmid= 9546360 |doi=  }}
*{{cite journal  |vauthors=Boerma M, Forsberg L, Van Zeijl L |title=A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development |journal=J. Intern. Med. |volume=246 |issue= 2 |pages= 211–8 |year= 1999 |pmid= 10447790 |doi=10.1046/j.1365-2796.1999.00564.x |display-authors=etal}}
*{{cite journal  | author=van Rijen HV, van Kempen MJ, Postma S, Jongsma HJ |title=Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. |journal=Cytokine |volume=10 |issue= 4 |pages= 258-64 |year= 1998 |pmid= 9617570 |doi= 10.1006/cyto.1997.0287 }}
*{{cite journal  |vauthors=Saito T, Krutovskikh V, Marion MJ |title=Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 67–70 |year= 2000 |pmid= 10728596 |doi=10.1002/(SICI)1097-0215(20000401)86:1<67::AID-IJC10>3.0.CO;2-1 |display-authors=etal}}
*{{cite journal  | author=Richard G, Smith LE, Bailey RA, ''et al.'' |title=Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. |journal=Nat. Genet. |volume=20 |issue= 4 |pages= 366-9 |year= 1998 |pmid= 9843209 |doi= 10.1038/3840 }}
*{{cite journal  |vauthors=Suzuki Y, Taira H, Tsunoda T |title=Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites |journal=EMBO Rep. |volume=2 |issue= 5 |pages= 388–93 |year= 2001 |pmid= 11375929 |doi= 10.1093/embo-reports/kve085 | pmc=1083880 |display-authors=etal}}
*{{cite journal  | author=Boerma M, Forsberg L, Van Zeijl L, ''et al.'' |title=A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development. |journal=J. Intern. Med. |volume=246 |issue= 2 |pages= 211-8 |year= 1999 |pmid= 10447790 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Saito T, Krutovskikh V, Marion MJ, ''et al.'' |title=Human hemangiosarcomas have a common polymorphism but no mutations in the connexin37 gene. |journal=Int. J. Cancer |volume=86 |issue= 1 |pages= 67-70 |year= 2000 |pmid= 10728596 |doi=  }}
*{{cite journal  |vauthors=Tsai MY, Lan KC, Huang KE |title=Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles |journal=Fertil. Steril. |volume=80 |issue= 6 |pages= 1437–43 |year= 2004 |pmid= 14667880 |doi=10.1016/j.fertnstert.2003.05.015 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Taira H, Tsunoda T, ''et al.'' |title=Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. |journal=EMBO Rep. |volume=2 |issue= 5 |pages= 388-93 |year= 2001 |pmid= 11375929 |doi= 10.1093/embo-reports/kve085 }}
*{{cite journal  |vauthors=Seul KH, Kang KY, Lee KS |title=Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 4 |pages= 1144–51 |year= 2004 |pmid= 15194487 |doi= 10.1016/j.bbrc.2004.05.097 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Kameritsch P, Khandoga N, Nagel W |title=Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 233–42 |year= 2005 |pmid= 15481066 |doi= 10.1002/jcp.20218 |display-authors=etal}}
*{{cite journal  | author=Tsai MY, Lan KC, Huang KE, ''et al.'' |title=Significance of mRNA levels of connexin37, connexin43, and connexin45 in luteinized granulosa cells of controlled hyperstimulated follicles. |journal=Fertil. Steril. |volume=80 |issue= 6 |pages= 1437-43 |year= 2004 |pmid= 14667880 |doi=  }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Seul KH, Kang KY, Lee KS, ''et al.'' |title=Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 4 |pages= 1144-51 |year= 2004 |pmid= 15194487 |doi= 10.1016/j.bbrc.2004.05.097 }}
*{{cite journal  | author=Kameritsch P, Khandoga N, Nagel W, ''et al.'' |title=Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules. |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 233-42 |year= 2005 |pmid= 15481066 |doi= 10.1002/jcp.20218 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Ion channels|g4}}
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}
 
[[Category:Connexins]]

Revision as of 08:45, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gap junction alpha-4 protein is a protein that in humans is encoded by the GJA4 gene.[1][2][3]

References

  1. ↑ Richard G, Smith LE, Bailey RA, Itin P, Hohl D, Epstein EH Jr, DiGiovanna JJ, Compton JG, Bale SJ (Dec 1998). "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis". Nat Genet. 20 (4): 366–9. doi:10.1038/3840. PMID 9843209.
  2. ↑ Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (Apr 1993). "Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein". J Clin Invest. 91 (3): 997–1004. doi:10.1172/JCI116321. PMC 288052. PMID 7680674.
  3. ↑ "Entrez Gene: GJA4 gap junction protein, alpha 4, 37kDa".

Further reading


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