Nuclear receptor co-repressor 2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
The '''nuclear receptor co-repressor 2''' ({{gene|NCOR2}}) is a [[transcription coregulator|transcriptional coregulatory]] protein that contains several [[nuclear receptor]]-interacting domains.  In addition, NCOR2 appears to recruit [[histone deacetylase]]s to DNA promoter regions.  Hence NCOR2 assists nuclear receptors in the down [[regulation of gene expression|regulation]] of target gene expression.<ref name="Chen_1995">{{cite journal | vauthors = Chen JD, Evans RM | title = A transcriptional co-repressor that interacts with nuclear hormone receptors | journal = Nature | volume = 377 | issue = 6548 | pages = 454–7 | date = October 1995 | pmid = 7566127 | doi = 10.1038/377454a0 }}</ref><ref name="Sande_1996">{{cite journal | vauthors = Sande S, Privalsky ML | title = Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors | journal = Molecular Endocrinology | volume = 10 | issue = 7 | pages = 813–25 | date = July 1996 | pmid = 8813722 | doi = 10.1210/me.10.7.813 }}</ref> NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors ('''SMRT''')<ref name="Chen_1995"/> or T<sub>3</sub> receptor-associating cofactor 1 ('''TRAC-1''').<ref name="Sande_1996"/>
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== Function ==
{{GNF_Protein_box
NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three [[C-terminus|C-terminal]] nuclear receptor-interacting domains.<ref name="Chen_1995"/> NCOR2/SMRT serves as a repressive coregulatory factor ([[corepressor (genetics)|corepressor]]) for multiple [[transcription factor]] pathways.  In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of [[histone deacetylase]]s to the DNA promoters bound by its interacting transcription factors.<ref name="Nagy_1997">{{cite journal | vauthors = Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM | title = Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase | journal = Cell | volume = 89 | issue = 3 | pages = 373–80 | date = May 1997 | pmid = 9150137 | doi = 10.1016/S0092-8674(00)80218-4 }}</ref>
| image = PBB_Protein_NCOR2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xc5.
| PDB = {{PDB2|1xc5}}
| Name = Nuclear receptor co-repressor 2
| HGNCid = 7673
| Symbol = NCOR2
| AltSymbols =; CTG26; TNRC14; TRAC1; SMRT; SMRTE; SMRTE-tau; TRAC-1
| OMIM = 600848
| ECnumber = 
| Homologene = 31370
| MGIid = 1337080
| GeneAtlas_image1 = PBB_GE_NCOR2_207760_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOR2_208888_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOR2_208889_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9612
    | Hs_Ensembl = ENSG00000196498
    | Hs_RefseqProtein = NP_001070729
    | Hs_RefseqmRNA = NM_001077261
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 123374915
    | Hs_GenLoc_end = 123545750
    | Hs_Uniprot = Q9Y618
    | Mm_EntrezGene = 20602
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011424
    | Mm_RefseqProtein = NP_035554
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
The '''nuclear receptor co-repressor 2''' ({{gene|NCOR2}}) is a transcriptional coregulatory protein which contains several [[nuclear receptor]] interacting domains.  In addition, NCOR2 appears to recruit [[histone deacetylase]]s to DNA promoter regions.  Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.<ref name="Chen_1995">{{cite journal |author=Chen JD, Evans RM|title=A transcriptional co-repressor that interacts with nuclear hormone receptors|journal= Nature |volume= 377 |issue= 6548 |pages= 454-7 |year= 1995| doi = 10.1038/377454a0 |pmid= 7566127}}</ref><ref name="Sande_1996">{{cite journal |author=Sande S, Privalsky ML|title=Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors|journal= Mol Endocrinol |volume= 10 |issue= 7 |pages= 813-25 |year= 1996| doi = 10.1210/me.10.7.813 |pmid= 8813722}}</ref>


NCOA2 is also sometimes referred to as silencing mediator for retinoid and thyroid-hormone receptors ('''SMRT''') or T3 receptor-associating cofactor 1 ('''TRAC-1''').
==Family==
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is [[Nuclear receptor co-repressor 1]].<ref name=uniprotfam>UniProt [http://www.uniprot.org/uniprot/?query=family:%22N-CoR+nuclear+receptor+corepressors+family%22 Nuclear receptor corepressors family] Page accessed June 26, 2016</ref>


==References==
== Discovery ==
<div class="references-small">{{reflist|2}}</div>
SMRT was initially cloned and characterized in the laboratory of Dr. [[Ronald M. Evans]] at the Salk Institute for Biological Studies.<ref name="Chen_1995"/> In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.<ref name="Sande_1996"/>


==External links==
== Interactions ==
* {{MeshName|nuclear+receptor+corepressor+2}}


==Further reading==
Nuclear receptor co-repressor 2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Androgen receptor|AR]],<ref name = pmid12441355>{{cite journal | vauthors = Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, Chen JD | title = Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT | journal = The Journal of Biological Chemistry | volume = 278 | issue = 7 | pages = 5052–61 | date = February 2003 | pmid = 12441355 | doi = 10.1074/jbc.M206374200 }}</ref><ref name = pmid14593076>{{cite journal | vauthors = Song LN, Coghlan M, Gelmann EP | title = Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor | journal = Molecular Endocrinology | volume = 18 | issue = 1 | pages = 70–85 | date = January 2004 | pmid = 14593076 | doi = 10.1210/me.2003-0189 }}</ref><ref name = pmid11923464>{{cite journal | vauthors = Dotzlaw H, Moehren U, Mink S, Cato AC, Iñiguez Lluhí JA, Baniahmad A | title = The amino terminus of the human AR is target for corepressor action and antihormone agonism | journal = Molecular Endocrinology | volume = 16 | issue = 4 | pages = 661–73 | date = April 2002 | pmid = 11923464 | doi = 10.1210/me.16.4.661 }}</ref>
* [[BCL6]],<ref name = pmid9765306/><ref name = pmid10898795>{{cite journal | vauthors = Huynh KD, Fischle W, Verdin E, Bardwell VJ | title = BCoR, a novel corepressor involved in BCL-6 repression | journal = Genes & Development | volume = 14 | issue = 14 | pages = 1810–23 | date = July 2000 | pmid = 10898795 | pmc = 316791 | doi = 10.1101/gad.14.14.1810 }}</ref><ref name = pmid10611298>{{cite journal | vauthors = Deltour S, Guerardel C, Leprince D | title = Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14831–6 | date = December 1999 | pmid = 10611298 | pmc = 24733 | doi = 10.1073/pnas.96.26.14831 }}</ref>
* [[C-Fos]],<ref name = pmid10777532>{{cite journal | vauthors = Lee SK, Kim JH, Lee YC, Cheong J, Lee JW | title = Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12470–4 | date = April 2000 | pmid = 10777532 | doi = 10.1074/jbc.275.17.12470 }}</ref>
* [[C-jun]],<ref name = pmid10777532/>
* [[HDAC1]],<ref name = pmid11739383>{{cite journal | vauthors = Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D | title = Isolation and characterization of a novel class II histone deacetylase, HDAC10 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6656–66 | date = February 2002 | pmid = 11739383 | doi = 10.1074/jbc.M108055200 }}</ref><ref name = pmid11013263>{{cite journal | vauthors = Underhill C, Qutob MS, Yee SP, Torchia J | title = A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40463–70 | date = December 2000 | pmid = 11013263 | doi = 10.1074/jbc.M007864200 }}</ref>
* [[HDAC3]],<ref name = pmid11013263/><ref name = pmid10944117/><ref name = pmid12628926/><ref name = pmid12502735/><ref name = pmid10809664/><ref name = pmid11804585/><ref name = pmid14527417>{{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = September 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}</ref>
* [[HDAC4]],<ref name = pmid11804585>{{cite journal | vauthors = Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E | title = Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR | journal = Molecular Cell | volume = 9 | issue = 1 | pages = 45–57 | date = January 2002 | pmid = 11804585 | doi = 10.1016/S1097-2765(01)00429-4 }}</ref><ref name = pmid10640275/>
* [[Histone deacetylase 5|HDAC5]],<ref name = pmid10640275/>
* [[HDAC10]],<ref name = pmid11739383/>
* [[MeCP2]],<ref name="pmid23770565">{{cite journal | vauthors = Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A | title = Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor | journal = Nature Neuroscience | volume = 16 | issue = 7 | pages = 898–902 | date = July 2013 | pmid = 23770565 | doi = 10.1038/nn.3434 | pmc=3786392}}</ref>
* [[Nerve Growth factor IB|NR4A1]],<ref name = pmid11559707>{{cite journal | vauthors = Sohn YC, Kwak E, Na Y, Lee JW, Lee SK | title = Silencing mediator of retinoid and thyroid hormone receptors and activating signal cointegrator-2 as transcriptional coregulators of the orphan nuclear receptor Nur77 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 47 | pages = 43734–9 | date = November 2001 | pmid = 11559707 | doi = 10.1074/jbc.M107208200 }}</ref>
* [[POU2F1]],<ref name = pmid11134019>{{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K | title = Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 9720–5 | date = March 2001 | pmid = 11134019 | doi = 10.1074/jbc.M008531200 }}</ref>
* [[Peroxisome proliferator-activated receptor delta|PPARD]],<ref name = pmid11867749>{{cite journal | vauthors = Shi Y, Hon M, Evans RM | title = The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 5 | pages = 2613–8 | date = March 2002 | pmid = 11867749 | pmc = 122396 | doi = 10.1073/pnas.052707099 }}</ref>
* [[Progesterone receptor|PGR]],<ref name = pmid10757795>{{cite journal | vauthors = Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP | title = The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding | journal = Molecular and Cellular Biology | volume = 20 | issue = 9 | pages = 3102–15 | date = May 2000 | pmid = 10757795 | pmc = 85605 | doi = 10.1128/MCB.20.9.3102-3115.2000 }}</ref>
* [[Promyelocytic leukemia protein|PML]]<ref name = "pmid11430826">{{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Molecular Cell | volume = 7 | issue = 6 | pages = 1233–43 | date = June 2001 | pmid = 11430826 | doi = 10.1016/S1097-2765(01)00257-X }}</ref><ref name = "pmid11585900">{{cite journal | vauthors = Hong SH, Yang Z, Privalsky ML | title = Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7172–82 | date = November 2001 | pmid = 11585900 | pmc = 99892 | doi = 10.1128/MCB.21.21.7172-7182.2001 }}</ref>
* [[RBPJ]],<ref name = pmid11404076>{{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1–2 | pages = 3–20 | date = June 2001 | pmid = 11404076 | doi = 10.1016/S0925-4773(01)00373-2 }}</ref><ref name = pmid11509665>{{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = September 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/MCB.21.18.6222-6232.2001 }}</ref>
* [[RELA]],<ref name = pmid10777532/><ref name = pmid12589049>{{cite journal | vauthors = Espinosa L, Inglés-Esteve J, Robert-Moreno A, Bigas A | title = IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways | journal = Molecular Biology of the Cell | volume = 14 | issue = 2 | pages = 491–502 | date = February 2003 | pmid = 12589049 | pmc = 149987 | doi = 10.1091/mbc.E02-07-0404 }}</ref>
* [[RUNX1T1]],<ref name = pmid14982881/><ref name = pmid11113190>{{cite journal | vauthors = Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA | title = Oligomerization of ETO is obligatory for corepressor interaction | journal = Molecular and Cellular Biology | volume = 21 | issue = 1 | pages = 156–63 | date = January 2001 | pmid = 11113190 | pmc = 88789 | doi = 10.1128/MCB.21.1.156-163.2001 }}</ref>
* [[Retinoic acid receptor alpha|RARA]],<ref name = pmid11929748>{{cite journal | vauthors = Dong S, Tweardy DJ | title = Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways | journal = Blood | volume = 99 | issue = 8 | pages = 2637–46 | date = April 2002 | pmid = 11929748 | doi = 10.1182/blood.V99.8.2637 }}</ref><ref name = pmid9256429>{{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | date = August 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 }}</ref>
* [[SIN3A]],<ref name = pmid10944117>{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}</ref><ref name = pmid10640275>{{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | journal = Genes & Development | volume = 14 | issue = 1 | pages = 45–54 | date = January 2000 | pmid = 10640275 | pmc = 316335 | doi =  }}</ref>
* [[SNW1]],<ref name = pmid10644367>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = February 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/JVI.74.4.1939-1947.2000 }}</ref><ref name = pmid10713164>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = April 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}</ref>
* [[SPEN]],<ref name = pmid11331609>{{cite journal | vauthors = Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM | title = Sharp, an inducible cofactor that integrates nuclear receptor repression and activation | journal = Genes & Development | volume = 15 | issue = 9 | pages = 1140–51 | date = May 2001 | pmid = 11331609 | pmc = 312688 | doi = 10.1101/gad.871201 }}</ref>
* [[Serum response factor|SRF]],<ref name = pmid10777532/>
* [[TBL1X]],<ref name = pmid10944117/><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = The EMBO Journal | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref><ref name = pmid12502735>{{cite journal | vauthors = Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA | title = Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex | journal = Genes & Development | volume = 16 | issue = 24 | pages = 3130–5 | date = December 2002 | pmid = 12502735 | pmc = 187500 | doi = 10.1101/gad.1037502 }}</ref><ref name = pmid10809664>{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes & Development | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048 }}</ref>
* [[Thyroid hormone receptor beta|THRB]],<ref name = pmid9751500>{{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–204 | date = October 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 }}</ref><ref name = pmid9878542>{{cite journal | vauthors = Tagami T, Lutz WH, Kumar R, Jameson JL | title = The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators | journal = Biochemical and Biophysical Research Communications | volume = 253 | issue = 2 | pages = 358–63 | date = December 1998 | pmid = 9878542 | doi = 10.1006/bbrc.1998.9799 }}</ref><ref name = pmid11518802>{{cite journal | vauthors = Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM | title = Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance | journal = Molecular Endocrinology | volume = 15 | issue = 9 | pages = 1529–38 | date = September 2001 | pmid = 11518802 | doi = 10.1210/me.15.9.1529 }}</ref>
* [[Calcitriol receptor|VDR]],<ref name = pmid9878542/><ref name = pmid12460926>{{cite journal | vauthors = Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M | title = AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor | journal = Cancer Research | volume = 62 | issue = 23 | pages = 7050–8 | date = December 2002 | pmid = 12460926 | doi =  }}</ref> and
* [[Zinc finger and BTB domain-containing protein 16|ZBTB16]].<ref name = pmid9765306>{{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 }}</ref><ref name = pmid14982881>{{cite journal | vauthors = Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD | title = The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT | journal = Blood | volume = 103 | issue = 12 | pages = 4650–8 | date = June 2004 | pmid = 14982881 | doi = 10.1182/blood-2003-08-2759 }}</ref><ref name = pmid9256429/>
{{Div col end}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK | title = Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor | journal = Nature | volume = 377 | issue = 6548 | pages = 397–404 | date = October 1995 | pmid = 7566114 | doi = 10.1038/377397a0 }}
| citations =
* {{cite journal | vauthors = Chen JD, Evans RM | title = A transcriptional co-repressor that interacts with nuclear hormone receptors | journal = Nature | volume = 377 | issue = 6548 | pages = 454–7 | date = October 1995 | pmid = 7566127 | doi = 10.1038/377454a0 }}
*{{cite journal | author=Hörlein AJ, Näär AM, Heinzel T, ''et al.'' |title=Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. |journal=Nature |volume=377 |issue= 6548 |pages= 397-404 |year= 1995 |pmid= 7566114 |doi= 10.1038/377397a0 }}
* {{cite journal | vauthors = Sande S, Privalsky ML | title = Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors | journal = Molecular Endocrinology | volume = 10 | issue = 7 | pages = 813–25 | date = July 1996 | pmid = 8813722 | doi = 10.1210/me.10.7.813 }}
*{{cite journal | author=Chen JD, Evans RM |title=A transcriptional co-repressor that interacts with nuclear hormone receptors. |journal=Nature |volume=377 |issue= 6548 |pages= 454-7 |year= 1995 |pmid= 7566127 |doi= 10.1038/377454a0 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Sande S, Privalsky ML |title=Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors. |journal=Mol. Endocrinol. |volume=10 |issue= 7 |pages= 813-25 |year= 1997 |pmid= 8813722 |doi= }}
* {{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Human Genetics | volume = 100 | issue = 1 | pages = 114–22 | date = July 1997 | pmid = 9225980 | doi = 10.1007/s004390050476 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | date = August 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 }}
*{{cite journal | author=Margolis RL, Abraham MR, Gatchell SB, ''et al.'' |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114-22 |year= 1997 |pmid= 9225980 |doi= }}
* {{cite journal | vauthors = Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM | title = Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300 | journal = Cell | volume = 90 | issue = 3 | pages = 569–80 | date = August 1997 | pmid = 9267036 | doi = 10.1016/S0092-8674(00)80516-4 }}
*{{cite journal | author=Hong SH, David G, Wong CW, ''et al.'' |title=SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 17 |pages= 9028-33 |year= 1997 |pmid= 9256429 |doi= }}
* {{cite journal | vauthors = Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM | title = Role of the histone deacetylase complex in acute promyelocytic leukaemia | journal = Nature | volume = 391 | issue = 6669 | pages = 811–4 | date = February 1998 | pmid = 9486654 | doi = 10.1038/35895 }}
*{{cite journal | author=Chen H, Lin RJ, Schiltz RL, ''et al.'' |title=Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. |journal=Cell |volume=90 |issue= 3 |pages= 569-80 |year= 1997 |pmid= 9267036 |doi= }}
* {{cite journal | vauthors = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors | journal = Molecular Cell | volume = 2 | issue = 1 | pages = 33–42 | date = July 1998 | pmid = 9702189 | doi = 10.1016/S1097-2765(00)80111-2 }}
*{{cite journal | author=Lin RJ, Nagy L, Inoue S, ''et al.'' |title=Role of the histone deacetylase complex in acute promyelocytic leukaemia. |journal=Nature |volume=391 |issue= 6669 |pages= 811-4 |year= 1998 |pmid= 9486654 |doi= 10.1038/35895 }}
* {{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–204 | date = October 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 }}
*{{cite journal | author=Laherty CD, Billin AN, Lavinsky RM, ''et al.'' |title=SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. |journal=Mol. Cell |volume=2 |issue= 1 |pages= 33-42 |year= 1998 |pmid= 9702189 |doi= }}
* {{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27695–702 | date = October 1998 | pmid = 9765306 | doi = 10.1074/jbc.273.42.27695 }}
*{{cite journal | author=Liu Y, Takeshita A, Misiti S, ''et al.'' |title=Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. |journal=Endocrinology |volume=139 |issue= 10 |pages= 4197-204 |year= 1998 |pmid= 9751500 |doi= }}
* {{cite journal | vauthors = Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM | title = Unique forms of human and mouse nuclear receptor corepressor SMRT | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 6 | pages = 2639–44 | date = March 1999 | pmid = 10077563 | pmc = 15821 | doi = 10.1073/pnas.96.6.2639 }}
*{{cite journal | author=Wong CW, Privalsky ML |title=Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27695-702 |year= 1998 |pmid= 9765306 |doi= }}
* {{cite journal | vauthors = Park EJ, Schroen DJ, Yang M, Li H, Li L, Chen JD | title = SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3519–24 | date = March 1999 | pmid = 10097068 | pmc = 22325 | doi = 10.1073/pnas.96.7.3519 }}
*{{cite journal | author=Ordentlich P, Downes M, Xie W, ''et al.'' |title=Unique forms of human and mouse nuclear receptor corepressor SMRT. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2639-44 |year= 1999 |pmid= 10077563 |doi= }}
* {{cite journal | vauthors = Nguyen TA, Hoivik D, Lee JE, Safe S | title = Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex | journal = Archives of Biochemistry and Biophysics | volume = 367 | issue = 2 | pages = 250–7 | date = July 1999 | pmid = 10395741 | doi = 10.1006/abbi.1999.1282 }}
*{{cite journal | author=Park EJ, Schroen DJ, Yang M, ''et al.'' |title=SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3519-24 |year= 1999 |pmid= 10097068 |doi= }}
* {{cite journal | vauthors = Bailey P, Downes M, Lau P, Harris J, Chen SL, Hamamori Y, Sartorelli V, Muscat GE | title = The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD | journal = Molecular Endocrinology | volume = 13 | issue = 7 | pages = 1155–68 | date = July 1999 | pmid = 10406466 | doi = 10.1210/me.13.7.1155 }}
*{{cite journal | author=Nguyen TA, Hoivik D, Lee JE, Safe S |title=Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. |journal=Arch. Biochem. Biophys. |volume=367 |issue= 2 |pages= 250-7 |year= 1999 |pmid= 10395741 |doi= 10.1006/abbi.1999.1282 }}
* {{cite journal | vauthors = Kao HY, Downes M, Ordentlich P, Evans RM | title = Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression | journal = Genes & Development | volume = 14 | issue = 1 | pages = 55–66 | date = January 2000 | pmid = 10640276 | pmc = 316336 | doi = 10.1101/gad.14.1.55 }}
*{{cite journal | author=Bailey P, Downes M, Lau P, ''et al.'' |title=The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD. |journal=Mol. Endocrinol. |volume=13 |issue= 7 |pages= 1155-68 |year= 1999 |pmid= 10406466 |doi= }}
* {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = April 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
*{{cite journal | author=Kao HY, Downes M, Ordentlich P, Evans RM |title=Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. |journal=Genes Dev. |volume=14 |issue= 1 |pages= 55-66 |year= 2000 |pmid= 10640276 |doi= }}
* {{cite journal | vauthors = Lee SK, Kim JH, Lee YC, Cheong J, Lee JW | title = Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor | journal = The Journal of Biological Chemistry | volume = 275 | issue = 17 | pages = 12470–4 | date = April 2000 | pmid = 10777532 | doi = 10.1074/jbc.275.17.12470 }}
*{{cite journal | author=Zhou S, Fujimuro M, Hsieh JJ, ''et al.'' |title=SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2400-10 |year= 2000 |pmid= 10713164 |doi= }}
* {{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes & Development | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi = 10.1101/gad.14.9.1048 }}
*{{cite journal | author=Lee SK, Kim JH, Lee YC, ''et al.'' |title=Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12470-4 |year= 2000 |pmid= 10777532 |doi= }}
* {{cite journal | vauthors = Grozinger CM, Schreiber SL | title = Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 14 | pages = 7835–40 | date = July 2000 | pmid = 10869435 | pmc = 16631 | doi = 10.1073/pnas.140199597 }}
*{{cite journal | author=Guenther MG, Lane WS, Fischle W, ''et al.'' |title=A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. |journal=Genes Dev. |volume=14 |issue= 9 |pages= 1048-57 |year= 2000 |pmid= 10809664 |doi= }}
*{{cite journal | author=Grozinger CM, Schreiber SL |title=Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7835-40 |year= 2000 |pmid= 10869435 |doi= 10.1073/pnas.140199597 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9612}}


{{biochem-stub}}
{{Transcription coregulators}}
{{Transcription coregulators}}
== External links ==
* {{MeshName|nuclear+receptor+corepressor+2|3=nuclear receptor corepressor 2}}
* {{NURSA|C98}}
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]

Revision as of 12:09, 3 May 2017

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The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression.[1][2] NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT)[1] or T3 receptor-associating cofactor 1 (TRAC-1).[2]

Function

NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains.[1] NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.[3]

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.[4]

Discovery

SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.[1] In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.[2]

Interactions

Nuclear receptor co-repressor 2 has been shown to interact with:

References

  1. ↑ 1.0 1.1 1.2 1.3 Chen JD, Evans RM (October 1995). "A transcriptional co-repressor that interacts with nuclear hormone receptors". Nature. 377 (6548): 454–7. doi:10.1038/377454a0. PMID 7566127.
  2. ↑ 2.0 2.1 2.2 Sande S, Privalsky ML (July 1996). "Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors". Molecular Endocrinology. 10 (7): 813–25. doi:10.1210/me.10.7.813. PMID 8813722.
  3. ↑ Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (May 1997). "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase". Cell. 89 (3): 373–80. doi:10.1016/S0092-8674(00)80218-4. PMID 9150137.
  4. ↑ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
  5. ↑ Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, Chen JD (February 2003). "Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT". The Journal of Biological Chemistry. 278 (7): 5052–61. doi:10.1074/jbc.M206374200. PMID 12441355.
  6. ↑ Song LN, Coghlan M, Gelmann EP (January 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Molecular Endocrinology. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.
  7. ↑ Dotzlaw H, Moehren U, Mink S, Cato AC, Iñiguez Lluhí JA, Baniahmad A (April 2002). "The amino terminus of the human AR is target for corepressor action and antihormone agonism". Molecular Endocrinology. 16 (4): 661–73. doi:10.1210/me.16.4.661. PMID 11923464.
  8. ↑ 8.0 8.1 Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306.
  9. ↑ Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes & Development. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
  10. ↑ Deltour S, Guerardel C, Leprince D (December 1999). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14831–6. doi:10.1073/pnas.96.26.14831. PMC 24733. PMID 10611298.
  11. ↑ 11.0 11.1 11.2 11.3 Lee SK, Kim JH, Lee YC, Cheong J, Lee JW (April 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". The Journal of Biological Chemistry. 275 (17): 12470–4. doi:10.1074/jbc.275.17.12470. PMID 10777532.
  12. ↑ 12.0 12.1 Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D (February 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry. 277 (8): 6656–66. doi:10.1074/jbc.M108055200. PMID 11739383.
  13. ↑ 13.0 13.1 Underhill C, Qutob MS, Yee SP, Torchia J (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". The Journal of Biological Chemistry. 275 (51): 40463–70. doi:10.1074/jbc.M007864200. PMID 11013263.
  14. ↑ 14.0 14.1 14.2 Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". The EMBO Journal. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
  15. ↑ 15.0 15.1 Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  16. ↑ 16.0 16.1 Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA (December 2002). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes & Development. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.
  17. ↑ 17.0 17.1 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes & Development. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID 10809664.
  18. ↑ 18.0 18.1 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell. 9 (1): 45–57. doi:10.1016/S1097-2765(01)00429-4. PMID 11804585.
  19. ↑ Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  20. ↑ 20.0 20.1 20.2 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes & Development. 14 (1): 45–54. PMC 316335. PMID 10640275.
  21. ↑ Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A (July 2013). "Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor". Nature Neuroscience. 16 (7): 898–902. doi:10.1038/nn.3434. PMC 3786392. PMID 23770565.
  22. ↑ Sohn YC, Kwak E, Na Y, Lee JW, Lee SK (November 2001). "Silencing mediator of retinoid and thyroid hormone receptors and activating signal cointegrator-2 as transcriptional coregulators of the orphan nuclear receptor Nur77". The Journal of Biological Chemistry. 276 (47): 43734–9. doi:10.1074/jbc.M107208200. PMID 11559707.
  23. ↑ Kakizawa T, Miyamoto T, Ichikawa K, Takeda T, Suzuki S, Mori J, Kumagai M, Yamashita K, Hashizume K (March 2001). "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". The Journal of Biological Chemistry. 276 (13): 9720–5. doi:10.1074/jbc.M008531200. PMID 11134019.
  24. ↑ Shi Y, Hon M, Evans RM (March 2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2613–8. doi:10.1073/pnas.052707099. PMC 122396. PMID 11867749.
  25. ↑ Giangrande PH, Kimbrel EA, Edwards DP, McDonnell DP (May 2000). "The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding". Molecular and Cellular Biology. 20 (9): 3102–15. doi:10.1128/MCB.20.9.3102-3115.2000. PMC 85605. PMID 10757795.
  26. ↑ Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (June 2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Molecular Cell. 7 (6): 1233–43. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826.
  27. ↑ Hong SH, Yang Z, Privalsky ML (November 2001). "Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia". Molecular and Cellular Biology. 21 (21): 7172–82. doi:10.1128/MCB.21.21.7172-7182.2001. PMC 99892. PMID 11585900.
  28. ↑ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076.
  29. ↑ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
  30. ↑ Espinosa L, Inglés-Esteve J, Robert-Moreno A, Bigas A (February 2003). "IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways". Molecular Biology of the Cell. 14 (2): 491–502. doi:10.1091/mbc.E02-07-0404. PMC 149987. PMID 12589049.
  31. ↑ 31.0 31.1 Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (June 2004). "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood. 103 (12): 4650–8. doi:10.1182/blood-2003-08-2759. PMID 14982881.
  32. ↑ Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Molecular and Cellular Biology. 21 (1): 156–63. doi:10.1128/MCB.21.1.156-163.2001. PMC 88789. PMID 11113190.
  33. ↑ Dong S, Tweardy DJ (April 2002). "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways". Blood. 99 (8): 2637–46. doi:10.1182/blood.V99.8.2637. PMID 11929748.
  34. ↑ 34.0 34.1 Hong SH, David G, Wong CW, Dejean A, Privalsky ML (August 1997). "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America. 94 (17): 9028–33. doi:10.1073/pnas.94.17.9028. PMC 23013. PMID 9256429.
  35. ↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  36. ↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
  37. ↑ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes & Development. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  38. ↑ Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (October 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. doi:10.1210/endo.139.10.6218. PMID 9751500.
  39. ↑ 39.0 39.1 Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochemical and Biophysical Research Communications. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542.
  40. ↑ Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM (September 2001). "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance". Molecular Endocrinology. 15 (9): 1529–38. doi:10.1210/me.15.9.1529. PMID 11518802.
  41. ↑ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Research. 62 (23): 7050–8. PMID 12460926.

Further reading


External links

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