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{{Infobox_gene}}
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'''Receptor-type tyrosine-protein phosphatase O''' is an [[enzyme]] that in humans is encoded by the ''PTPRO'' [[gene]].<ref name="pmid7519601">{{cite journal |vauthors=Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC | title = GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit | journal = J Biol Chem | volume = 269 | issue = 31 | pages = 19953–62 |date=Sep 1994 | pmid = 7519601 | pmc =  | doi =  }}</ref><ref name="pmid7665166">{{cite journal |vauthors=Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE | title = Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 | journal = Genomics | volume = 27 | issue = 1 | pages = 174–81 |date=Oct 1995 | pmid = 7665166 | pmc =  | doi = 10.1006/geno.1995.1021 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5800| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PTPRO_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g59.
| PDB = {{PDB2|2g59}}, {{PDB2|2gjt}}, {{PDB2|2pi7}}
| Name = Protein tyrosine phosphatase, receptor type, O
| HGNCid = 9678
| Symbol = PTPRO
| AltSymbols =; GLEPP1; PTP-U2; PTPU2
| OMIM = 600579
| ECnumber =
| Homologene = 21564
| MGIid = 1097152
  | GeneAtlas_image1 = PBB_GE_PTPRO_208121_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5800
    | Hs_Ensembl = ENSG00000151490
    | Hs_RefseqProtein = NP_002839
    | Hs_RefseqmRNA = NM_002848
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 15366754
    | Hs_GenLoc_end = 15641602
    | Hs_Uniprot = Q16827
    | Mm_EntrezGene = 19277
    | Mm_Ensembl = ENSMUSG00000030223
    | Mm_RefseqmRNA = NM_011216
    | Mm_RefseqProtein = NP_035346
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 137216661
    | Mm_GenLoc_end = 137427429
    | Mm_Uniprot = 
  }}
}}
'''Protein tyrosine phosphatase, receptor type, O''', also known as '''PTPRO''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5800| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.<ref name="entrez">{{cite web | title = Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5800| accessdate = }}</ref>
| summary_text = This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Thomas PE, Wharram BL, Goyal M, ''et al.'' |title=GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit. |journal=J. Biol. Chem. |volume=269 |issue= 31 |pages= 19953-62 |year= 1994 |pmid= 7519601 |doi=  }}
*{{cite journal  |vauthors=Seimiya H, Sawabe T, Inazawa J, Tsuruo T |title=Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents |journal=Oncogene |volume=10 |issue= 9 |pages= 1731–8 |year= 1995 |pmid= 7753550 |doi=  }}
*{{cite journal  | author=Wiggins RC, Wiggins JE, Goyal M, ''et al.'' |title=Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. |journal=Genomics |volume=27 |issue= 1 |pages= 174-81 |year= 1995 |pmid= 7665166 |doi= 10.1006/geno.1995.1021 }}
*{{cite journal  | author=Feito MJ |title=gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules |journal=Int. Immunol. |volume=9 |issue= 8 |pages= 1141–7 |year= 1997 |pmid= 9263011 |doi=10.1093/intimm/9.8.1141  |name-list-format=vanc| author2=Bragardo M  | author3=Buonfiglio D  | display-authors=3  | last4=Bonissoni  | first4=S  | last5=Bottarel  | first5=F  | last6=Malavasi  | first6=F  | last7=Dianzani  | first7=U }}
*{{cite journal  | author=Seimiya H, Sawabe T, Inazawa J, Tsuruo T |title=Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. |journal=Oncogene |volume=10 |issue= 9 |pages= 1731-8 |year= 1995 |pmid= 7753550 |doi=  }}
*{{cite journal  | author=Avraham S |title=Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells |journal=Gene |volume=204 |issue= 1–2 |pages= 5–16 |year= 1998 |pmid= 9434160 |doi=10.1016/S0378-1119(97)00420-4  |name-list-format=vanc| author2=London R  | author3=Tulloch GA  | display-authors=3  | last4=Ellis  | first4=Martin  | last5=Fu  | first5=Yigong  | last6=Jiang  | first6=Shuxian  | last7=White  | first7=Robert A  | last8=Painter  | first8=Christopher  | last9=Steinberger  | first9=A.A }}
*{{cite journal  | author=Feito MJ, Bragardo M, Buonfiglio D, ''et al.'' |title=gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules. |journal=Int. Immunol. |volume=9 |issue= 8 |pages= 1141-7 |year= 1997 |pmid= 9263011 |doi=  }}
*{{cite journal  | author=Taniguchi Y |title=The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor |journal=Blood |volume=94 |issue= 2 |pages= 539–49 |year= 1999 |pmid= 10397721 |doi= |name-list-format=vanc| author2=London R  | author3=Schinkmann K  | display-authors=3  | last4=Jiang  | first4=S  | last5=Avraham  | first5=H }}
*{{cite journal  | author=Avraham S, London R, Tulloch GA, ''et al.'' |title=Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. |journal=Gene |volume=204 |issue= 1-2 |pages= 5-16 |year= 1998 |pmid= 9434160 |doi=  }}
*{{cite journal  | author=Aguiar RC |title=PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest |journal=Blood |volume=94 |issue= 7 |pages= 2403–13 |year= 1999 |pmid= 10498613 |doi= |name-list-format=vanc| author2=Yakushijin Y  | author3=Kharbanda S  | display-authors=3  | last4=Tiwari  | first4=S  | last5=Freeman  | first5=GJ  | last6=Shipp  | first6=MA }}
*{{cite journal  | author=Taniguchi Y, London R, Schinkmann K, ''et al.'' |title=The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. |journal=Blood |volume=94 |issue= 2 |pages= 539-49 |year= 1999 |pmid= 10397721 |doi=  }}
*{{cite journal  | author=Wang Z |title=Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells |journal=Arch. Biochem. Biophys. |volume=390 |issue= 1 |pages= 9–18 |year= 2001 |pmid= 11368509 |doi= 10.1006/abbi.2001.2370 |name-list-format=vanc| author2=Bhattacharya N  | author3=Meyer MK  | display-authors=3  | last4=Seimiya  | first4=H  | last5=Tsuruo  | first5=T  | last6=Tonani  | first6=JA  | last7=Magnuson  | first7=NS }}
*{{cite journal  | author=Aguiar RC, Yakushijin Y, Kharbanda S, ''et al.'' |title=PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest. |journal=Blood |volume=94 |issue= 7 |pages= 2403-13 |year= 1999 |pmid= 10498613 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Wang Z, Bhattacharya N, Meyer MK, ''et al.'' |title=Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. |journal=Arch. Biochem. Biophys. |volume=390 |issue= 1 |pages= 9-18 |year= 2001 |pmid= 11368509 |doi= 10.1006/abbi.2001.2370 }}
*{{cite journal  | author=Motiwala T |title=Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13844–9 |year= 2004 |pmid= 15356345 |doi= 10.1073/pnas.0405451101 | pmc=518843  |name-list-format=vanc| author2=Kutay H  | author3=Ghoshal K  | display-authors=3  | last4=Bai  | first4=S  | last5=Seimiya  | first5=H  | last6=Tsuruo  | first6=T  | last7=Suster  | first7=S  | last8=Morrison  | first8=C  | last9=Jacob  | first9=ST }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Chen L |title=Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation |journal=Blood |volume=108 |issue= 10 |pages= 3428–33 |year= 2007 |pmid= 16888096 |doi= 10.1182/blood-2006-03-013821 |name-list-format=vanc| author2=Juszczynski P  | author3=Takeyama K  | display-authors=3  | last4=Aguiar  | first4=R. C. T.  | last5=Shipp  | first5=M. A. }}
*{{cite journal  | author=Motiwala T, Kutay H, Ghoshal K, ''et al.'' |title=Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13844-9 |year= 2004 |pmid= 15356345 |doi= 10.1073/pnas.0405451101 }}
*{{cite journal  | author=Motiwala T |title=Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3174–81 |year= 2007 |pmid= 17545520 |doi= 10.1158/1078-0432.CCR-06-1720 |name-list-format=vanc| author2=Majumder S  | author3=Kutay H  | display-authors=3  | last4=Smith  | first4=D. S.  | last5=Neuberg  | first5=D. S.  | last6=Lucas  | first6=D. M.  | last7=Byrd  | first7=J. C.  | last8=Grever  | first8=M.  | last9=Jacob  | first9=S. T.  | pmc=3074612 }}
*{{cite journal  | author=Chen L, Juszczynski P, Takeyama K, ''et al.'' |title=Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation. |journal=Blood |volume=108 |issue= 10 |pages= 3428-33 |year= 2007 |pmid= 16888096 |doi= 10.1182/blood-2006-03-013821 }}
*{{cite journal  | author=Tian J |title=Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy |journal=J. Int. Med. Res. |volume=35 |issue= 3 |pages= 338–45 |year= 2007 |pmid= 17593862 |doi= 10.1177/147323000703500308|name-list-format=vanc| author2=Wang HP  | author3=Mao YY  | display-authors=3  | last4=Jin  | first4=J  | last5=Chen  | first5=JH }}
*{{cite journal  | author=Motiwala T, Majumder S, Kutay H, ''et al.'' |title=Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia. |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3174-81 |year= 2007 |pmid= 17545520 |doi= 10.1158/1078-0432.CCR-06-1720 }}
*{{cite journal  | author=Tian J, Wang HP, Mao YY, ''et al.'' |title=Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy. |journal=J. Int. Med. Res. |volume=35 |issue= 3 |pages= 338-45 |year= 2007 |pmid= 17593862 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5800}}
{{Protein tyrosine phosphatases}}
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Latest revision as of 18:59, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.[1][2][3]

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.[3]

References

  1. ↑ Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit". J Biol Chem. 269 (31): 19953–62. PMID 7519601.
  2. ↑ Wiggins RC, Wiggins JE, Goyal M, Wharram BL, Thomas PE (Oct 1995). "Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13". Genomics. 27 (1): 174–81. doi:10.1006/geno.1995.1021. PMID 7665166.
  3. ↑ 3.0 3.1 "Entrez Gene: PTPRO protein tyrosine phosphatase, receptor type, O".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PTPRO&oldid=1415804"