CACNB3: Difference between revisions

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Latest revision as of 09:08, 30 August 2017

Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.^[1]^[2]

References

↑ Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit". Eur J Biochem. 220 (1): 257–62. doi:10.1111/j.1432-1033.1994.tb18621.x. PMID 8119293.
↑ "Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

Yamada Y, Masuda K, Li Q, et al. (1995). "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes". Genomics. 27 (2): 312–9. doi:10.1006/geno.1995.1048. PMID 7557998.
Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen". Ann. Neurol. 33 (1): 113–20. doi:10.1002/ana.410330126. PMID 8494331.
Murakami M, Wissenbach U, Flockerzi V (1996). "Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products". Eur. J. Biochem. 236 (1): 138–43. doi:10.1111/j.1432-1033.1996.t01-1-00138.x. PMID 8617257.
Scott VE, De Waard M, Liu H, et al. (1996). "Beta subunit heterogeneity in N-type Ca2+ channels". J. Biol. Chem. 271 (6): 3207–12. doi:10.1074/jbc.271.6.3207. PMID 8621722.
Bell DC, Butcher AJ, Berrow NS, et al. (2001). "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents". J. Neurophysiol. 85 (2): 816–27. PMID 11160515.
Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells". J. Physiol. 541 (Pt 2): 435–52. doi:10.1113/jphysiol.2002.018515. PMC 2290333. PMID 12042350.
Murakami M, Fleischmann B, De Felipe C, et al. (2002). "Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels". J. Biol. Chem. 277 (43): 40342–51. doi:10.1074/jbc.M203425200. PMID 12161429.
Qin N, Yagel S, Momplaisir ML, et al. (2002). "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit". Mol. Pharmacol. 62 (3): 485–96. doi:10.1124/mol.62.3.485. PMID 12181424.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chen YH, Li MH, Zhang Y, et al. (2004). "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels". Nature. 429 (6992): 675–80. doi:10.1038/nature02641. PMID 15170217.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vendel AC, Terry MD, Striegel AR, et al. (2006). "Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex". J. Neurosci. 26 (10): 2635–44. doi:10.1523/JNEUROSCI.0067-06.2006. PMID 16525042.

External links

CACNB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CACNB3 genome location and CACNB3 gene details page in the UCSC Genome Browser.

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[pmid8119293-1] Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit". Eur J Biochem. 220 (1): 257–62. doi:10.1111/j.1432-1033.1994.tb18621.x. PMID 8119293.

[entrez-2] "Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Voltage-dependent L-type calcium channel subunit beta-3''' is a [[protein]] that in humans is encoded by the ''CACNB3'' [[gene]].<ref name="pmid8119293">{{cite journal | vauthors = Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J | title = Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit | journal = Eur J Biochem | volume = 220 | issue = 1 | pages = 257–62 |date=Apr 1994 | pmid = 8119293 | pmc =  | doi =10.1111/j.1432-1033.1994.tb18621.x  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=784| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CACNB3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vyt.
- | PDB = {{PDB2|1vyt}}, {{PDB2|1vyu}}
- | Name = Calcium channel, voltage-dependent, beta 3 subunit
- | HGNCid = 1403
- | Symbol = CACNB3
- | AltSymbols =; CACNLB3
- | OMIM = 601958
- | ECnumber =
- | Homologene = 20187
- | MGIid = 103307
-  | GeneAtlas_image1 = PBB_GE_CACNB3_34726_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CACNB3_209530_at_tn.png
- | Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0015270 |text = dihydropyridine-sensitive calcium channel activity}}
-  | Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 784
-    | Hs_Ensembl = ENSG00000167535
-    | Hs_RefseqProtein = NP_000716
-    | Hs_RefseqmRNA = NM_000725
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 47498779
-    | Hs_GenLoc_end = 47508991
-    | Hs_Uniprot = P54284
-    | Mm_EntrezGene = 12297
-    | Mm_Ensembl = ENSMUSG00000003352
-    | Mm_RefseqmRNA = NM_001044741
-    | Mm_RefseqProtein = NP_001038206
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 98463140
-    | Mm_GenLoc_end = 98472563
-    | Mm_Uniprot = Q8K5A7
-  }}
-}}
-'''Calcium channel, voltage-dependent, beta 3 subunit''', also known as '''CACNB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=784| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
@@ Line 59: / Line 11: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 65: / Line 17: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Yamada Y, Masuda K, Li Q, ''et al.'' |title=The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. |journal=Genomics |volume=27 |issue= 2 |pages= 312-9 |year= 1995 |pmid= 7557998 |doi= 10.1006/geno.1995.1048 }}
+*{{cite journal  | vauthors=Yamada Y, Masuda K, Li Q |title=The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. |journal=Genomics |volume=27 |issue= 2 |pages= 312–9 |year= 1995 |pmid= 7557998 |doi= 10.1006/geno.1995.1048 |display-authors=etal}}
-*{{cite journal  | author=Collin T, Lory P, Taviaux S, ''et al.'' |title=Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit. |journal=Eur. J. Biochem. |volume=220 |issue= 1 |pages= 257-62 |year= 1994 |pmid= 8119293 |doi=  }}
+*{{cite journal  | vauthors=Rosenfeld MR, Wong E, Dalmau J |title=Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. |journal=Ann. Neurol. |volume=33 |issue= 1 |pages= 113–20 |year= 1993 |pmid= 8494331 |doi= 10.1002/ana.410330126 |display-authors=etal}}
-*{{cite journal  | author=Rosenfeld MR, Wong E, Dalmau J, ''et al.'' |title=Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen. |journal=Ann. Neurol. |volume=33 |issue= 1 |pages= 113-20 |year= 1993 |pmid= 8494331 |doi= 10.1002/ana.410330126 }}
+*{{cite journal  | vauthors=Murakami M, Wissenbach U, Flockerzi V |title=Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products. |journal=Eur. J. Biochem. |volume=236 |issue= 1 |pages= 138–43 |year= 1996 |pmid= 8617257 |doi=10.1111/j.1432-1033.1996.t01-1-00138.x  }}
-*{{cite journal  | author=Murakami M, Wissenbach U, Flockerzi V |title=Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products. |journal=Eur. J. Biochem. |volume=236 |issue= 1 |pages= 138-43 |year= 1996 |pmid= 8617257 |doi=  }}
+*{{cite journal  | vauthors=Scott VE, De Waard M, Liu H |title=Beta subunit heterogeneity in N-type Ca2+ channels. |journal=J. Biol. Chem. |volume=271 |issue= 6 |pages= 3207–12 |year= 1996 |pmid= 8621722 |doi=10.1074/jbc.271.6.3207  |display-authors=etal}}
-*{{cite journal  | author=Scott VE, De Waard M, Liu H, ''et al.'' |title=Beta subunit heterogeneity in N-type Ca2+ channels. |journal=J. Biol. Chem. |volume=271 |issue= 6 |pages= 3207-12 |year= 1996 |pmid= 8621722 |doi=  }}
+*{{cite journal  | vauthors=Bell DC, Butcher AJ, Berrow NS |title=Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. |journal=J. Neurophysiol. |volume=85 |issue= 2 |pages= 816–27 |year= 2001 |pmid= 11160515 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Bell DC, Butcher AJ, Berrow NS, ''et al.'' |title=Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. |journal=J. Neurophysiol. |volume=85 |issue= 2 |pages= 816-27 |year= 2001 |pmid= 11160515 |doi=  }}
+*{{cite journal  | vauthors=Colecraft HM, Alseikhan B, Takahashi SX |title=Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. |journal=J. Physiol. |volume=541 |issue= Pt 2 |pages= 435–52 |year= 2002 |pmid= 12042350 |doi=10.1113/jphysiol.2002.018515  | pmc=2290333  |display-authors=etal}}
-*{{cite journal  | author=Colecraft HM, Alseikhan B, Takahashi SX, ''et al.'' |title=Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. |journal=J. Physiol. (Lond.) |volume=541 |issue= Pt 2 |pages= 435-52 |year= 2002 |pmid= 12042350 |doi=  }}
+*{{cite journal  | vauthors=Murakami M, Fleischmann B, De Felipe C |title=Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40342–51 |year= 2002 |pmid= 12161429 |doi= 10.1074/jbc.M203425200 |display-authors=etal}}
-*{{cite journal  | author=Murakami M, Fleischmann B, De Felipe C, ''et al.'' |title=Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40342-51 |year= 2002 |pmid= 12161429 |doi= 10.1074/jbc.M203425200 }}
+*{{cite journal  | vauthors=Qin N, Yagel S, Momplaisir ML |title=Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. |journal=Mol. Pharmacol. |volume=62 |issue= 3 |pages= 485–96 |year= 2002 |pmid= 12181424 |doi=10.1124/mol.62.3.485  |display-authors=etal}}
-*{{cite journal  | author=Qin N, Yagel S, Momplaisir ML, ''et al.'' |title=Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. |journal=Mol. Pharmacol. |volume=62 |issue= 3 |pages= 485-96 |year= 2002 |pmid= 12181424 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Chen YH, Li MH, Zhang Y |title=Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. |journal=Nature |volume=429 |issue= 6992 |pages= 675–80 |year= 2004 |pmid= 15170217 |doi= 10.1038/nature02641 |display-authors=etal}}
-*{{cite journal  | author=Chen YH, Li MH, Zhang Y, ''et al.'' |title=Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. |journal=Nature |volume=429 |issue= 6992 |pages= 675-80 |year= 2004 |pmid= 15170217 |doi= 10.1038/nature02641 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Vendel AC, Terry MD, Striegel AR |title=Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. |journal=J. Neurosci. |volume=26 |issue= 10 |pages= 2635–44 |year= 2006 |pmid= 16525042 |doi= 10.1523/JNEUROSCI.0067-06.2006 |display-authors=etal}}
-*{{cite journal  | author=Vendel AC, Terry MD, Striegel AR, ''et al.'' |title=Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. |journal=J. Neurosci. |volume=26 |issue= 10 |pages= 2635-44 |year= 2006 |pmid= 16525042 |doi= 10.1523/JNEUROSCI.0067-06.2006 }}
 }}
 {{refend}}
@@ Line 84: / Line 35: @@
 == External links ==
 * {{MeshName|CACNB3+protein,+human}}
+* {{UCSC gene info|CACNB3}}
+{{PDB Gallery|geneid=784}}
+{{Ion channels|g1}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:Ion channels]]
 {{membrane-protein-stub}}
-{{Ion channels}}
-[[Category:Ion channels]]
-{{WikiDoc Sources}}

CACNB3: Difference between revisions

Latest revision as of 09:08, 30 August 2017

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See also

References

Further reading

External links

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