CDKN3: Difference between revisions

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{{Infobox_gene}}
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'''Cyclin-dependent kinase inhibitor 3''' is an [[enzyme]] that in humans is encoded by the ''CDKN3'' [[gene]].<ref name="pmid8242750">{{cite journal | vauthors = Gyuris J, Golemis E, Chertkov H, Brent R | title = Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 | journal = Cell | volume = 75 | issue = 4 | pages = 791–803 |date=Dec 1993 | pmid = 8242750 | pmc =  | doi =10.1016/0092-8674(93)90498-F }}</ref><ref name="pmid7698009">{{cite journal | vauthors = Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH | title = Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3) | journal = Cytogenet Cell Genet | volume = 69 | issue = 3–4 | pages = 190–2 |date=May 1995 | pmid = 7698009 | pmc =  | doi =10.1159/000133960 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CDKN3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fpz.
| PDB = {{PDB2|1fpz}}, {{PDB2|1fq1}}
| Name = Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
| HGNCid = 1791
| Symbol = CDKN3
| AltSymbols =; CDI1; CIP2; FLJ25787; KAP; KAP1; MGC70625
| OMIM = 123832
| ECnumber =
| Homologene = 3805
| MGIid = 1919641
  | GeneAtlas_image1 = PBB_GE_CDKN3_209714_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004721 |text = phosphoprotein phosphatase activity}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1033
    | Hs_Ensembl = ENSG00000100526
    | Hs_RefseqProtein = NP_005183
    | Hs_RefseqmRNA = NM_005192
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 53933423
    | Hs_GenLoc_end = 53956682
    | Hs_Uniprot = Q16667
    | Mm_EntrezGene = 72391
    | Mm_Ensembl = ENSMUSG00000037628
    | Mm_RefseqmRNA = XM_891957
    | Mm_RefseqProtein = XP_897050
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 45682434
    | Mm_GenLoc_end = 45693398
    | Mm_Uniprot = 
  }}
}}
'''Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)''', also known as '''CDKN3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.<ref name="entrez">{{cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.<ref name="entrez">{{cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = }}</ref>
}}
}}
==Interactions==
CDKN3 has been shown to [[Protein-protein interaction|interact]] with [[Cyclin-dependent kinase 2]],<ref name=pmid12745075>{{cite journal |last=Yeh |first=Chau-Ting |author2=Lu Su-Chuan |author3=Chao Chung-Hao |author4=Chao Mei-Ling  |date=May 2003 |title=Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue=2 |pages=311–4 |publisher= |location = United States| issn = 0006-291X| pmid = 12745075 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0006-291X(03)00757-5 }}</ref><ref name=pmid8127873>{{cite journal |last=Hannon |first=G J |author2=Casso D|author3=Beach D |date=Mar 1994 |title=KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=91 |issue=5 |pages=1731–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8127873 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.91.5.1731 |pmc=43237 }}</ref><ref name=pmid8242751>{{cite journal |last=Harper |first=J W |author2=Adami G R|author3=Wei N|author4=Keyomarsi K|author5=Elledge S J |date=Nov 1993 |title=The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases |journal=Cell |volume=75 |issue=4 |pages=805–16 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 8242751 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/0092-8674(93)90499-G }}</ref> [[Cdk1]]<ref name=pmid8242750 /><ref name=pmid8127873/> and [[MS4A3]].<ref name=pmid11781350>{{cite journal |last=Donato |first=José L |author2=Ko Jon |author3=Kutok Jeffery L |author4=Cheng Tao |author5=Shirakawa Taro |author6=Mao Xiao-Quan |author7=Beach David |author8=Scadden David T |author9=Sayegh Mohamed H |author10=Adra Chaker N  |date=Jan 2002 |title=Human HTm4 is a hematopoietic cell cycle regulator |journal=J. Clin. Invest. |volume=109 |issue=1 |pages=51–8 |publisher= |location = United States| issn = 0021-9738| pmid = 11781350 |doi = 10.1172/JCI14025 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=150822 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Poon RY, Hunter T |title=Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. |journal=Science |volume=270 |issue= 5233 |pages= 90-3 |year= 1995 |pmid= 7569954 |doi= }}
*{{cite journal  | vauthors=Poon RY, Hunter T |title=Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin |journal=Science |volume=270 |issue= 5233 |pages= 90–3 |year= 1995 |pmid= 7569954 |doi=10.1126/science.270.5233.90 }}
*{{cite journal  | author=Demetrick DJ, Matsumoto S, Hannon GJ, ''et al.'' |title=Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 190-2 |year= 1995 |pmid= 7698009 |doi= }}
*{{cite journal  | vauthors=Hannon GJ, Casso D, Beach D |title=KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1731–5 |year= 1994 |pmid= 8127873 |doi=10.1073/pnas.91.5.1731 | pmc=43237 }}
*{{cite journal  | author=Hannon GJ, Casso D, Beach D |title=KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1731-5 |year= 1994 |pmid= 8127873 |doi=  }}
*{{cite journal  | vauthors=Harper JW, Adami GR, Wei N |title=The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases |journal=Cell |volume=75 |issue= 4 |pages= 805–16 |year= 1993 |pmid= 8242751 |doi=10.1016/0092-8674(93)90499-G |display-authors=etal}}
*{{cite journal  | author=Gyuris J, Golemis E, Chertkov H, Brent R |title=Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. |journal=Cell |volume=75 |issue= 4 |pages= 791-803 |year= 1993 |pmid= 8242750 |doi=  }}
*{{cite journal  | vauthors=Sexl V, Diehl JA, Sherr CJ |title=A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2 |journal=Oncogene |volume=18 |issue= 3 |pages= 573–82 |year= 1999 |pmid= 9989807 |doi= 10.1038/sj.onc.1202362 |display-authors=etal}}
*{{cite journal  | author=Harper JW, Adami GR, Wei N, ''et al.'' |title=The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. |journal=Cell |volume=75 |issue= 4 |pages= 805-16 |year= 1993 |pmid= 8242751 |doi=  }}
*{{cite journal  | vauthors=Lee SW, Reimer CL, Fang L |title=Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1723–32 |year= 2000 |pmid= 10669749 |doi=10.1128/MCB.20.5.1723-1732.2000 | pmc=85355  |display-authors=etal}}
*{{cite journal  | author=Sexl V, Diehl JA, Sherr CJ, ''et al.'' |title=A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. |journal=Oncogene |volume=18 |issue= 3 |pages= 573-82 |year= 1999 |pmid= 9989807 |doi= 10.1038/sj.onc.1202362 }}
*{{cite journal  | vauthors=Yeh CT, Lu SC, Chen TC |title=Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4697–700 |year= 2000 |pmid= 10987270 |doi=  |display-authors=etal}}
*{{cite journal  | author=Lee SW, Reimer CL, Fang L, ''et al.'' |title=Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1723-32 |year= 2000 |pmid= 10669749 |doi=  }}
*{{cite journal  | vauthors=Song H, Hanlon N, Brown NR |title=Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2 |journal=Mol. Cell |volume=7 |issue= 3 |pages= 615–26 |year= 2001 |pmid= 11463386 |doi=10.1016/S1097-2765(01)00208-8 |display-authors=etal}}
*{{cite journal  | author=Yeh CT, Lu SC, Chen TC, ''et al.'' |title=Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4697-700 |year= 2000 |pmid= 10987270 |doi=  }}
*{{cite journal  | vauthors=Wang H, Iakova P, Wilde M |title=C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4 |journal=Mol. Cell |volume=8 |issue= 4 |pages= 817–28 |year= 2001 |pmid= 11684017 |doi=10.1016/S1097-2765(01)00366-5 |display-authors=etal}}
*{{cite journal  | author=Song H, Hanlon N, Brown NR, ''et al.'' |title=Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. |journal=Mol. Cell |volume=7 |issue= 3 |pages= 615-26 |year= 2001 |pmid= 11463386 |doi=  }}
*{{cite journal  | vauthors=Donato JL, Ko J, Kutok JL |title=Human HTm4 is a hematopoietic cell cycle regulator |journal=J. Clin. Invest. |volume=109 |issue= 1 |pages= 51–8 |year= 2002 |pmid= 11781350 |doi=10.1172/JCI14025 | pmc=150822  |display-authors=etal}}
*{{cite journal  | author=Wang H, Iakova P, Wilde M, ''et al.'' |title=C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 817-28 |year= 2001 |pmid= 11684017 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Donato JL, Ko J, Kutok JL, ''et al.'' |title=Human HTm4 is a hematopoietic cell cycle regulator. |journal=J. Clin. Invest. |volume=109 |issue= 1 |pages= 51-8 |year= 2002 |pmid= 11781350 |doi=  }}
*{{cite journal  | vauthors=Yeh CT, Lu SC, Chao CH, Chao ML |title=Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 311–4 |year= 2003 |pmid= 12745075 |doi=10.1016/S0006-291X(03)00757-5 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Niculescu MD |author2=Yamamuro Y |author3=Zeisel SH |authorlink3=Steven Zeisel |title=Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene |journal=J. Neurochem. |volume=89 |issue= 5 |pages= 1252–9 |year= 2004 |pmid= 15147518 |doi= 10.1111/j.1471-4159.2004.02414.x | pmc=1592524 }}
*{{cite journal  | author=Yeh CT, Lu SC, Chao CH, Chao ML |title=Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 311-4 |year= 2003 |pmid= 12745075 |doi=  }}
*{{cite journal  | vauthors=Chinami M, Yano Y, Yang X |title=Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2 |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17235–42 |year= 2005 |pmid= 15671017 |doi= 10.1074/jbc.M413437200 |display-authors=etal}}
*{{cite journal  | author=Niculescu MD, Yamamuro Y, Zeisel SH |title=Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. |journal=J. Neurochem. |volume=89 |issue= 5 |pages= 1252-9 |year= 2004 |pmid= 15147518 |doi= 10.1111/j.1471-4159.2004.02414.x }}
*{{cite journal  | vauthors=Hsieh MJ, Yao YL, Lai IL, Yang WM |title=Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1 |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 573–81 |year= 2006 |pmid= 16945326 |doi= 10.1016/j.bbrc.2006.08.064 }}
*{{cite journal  | author=Chinami M, Yano Y, Yang X, ''et al.'' |title=Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17235-42 |year= 2005 |pmid= 15671017 |doi= 10.1074/jbc.M413437200 }}
*{{cite journal  | vauthors=Okamoto K, Kitabayashi I, Taya Y |title=KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 1 |pages= 216–22 |year= 2006 |pmid= 17056014 |doi= 10.1016/j.bbrc.2006.10.022 }}
*{{cite journal  | author=Hsieh MJ, Yao YL, Lai IL, Yang WM |title=Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 573-81 |year= 2006 |pmid= 16945326 |doi= 10.1016/j.bbrc.2006.08.064 }}
*{{cite journal  | author=Okamoto K, Kitabayashi I, Taya Y |title=KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 1 |pages= 216-22 |year= 2006 |pmid= 17056014 |doi= 10.1016/j.bbrc.2006.10.022 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDKN3}}
* {{UCSC gene details|CDKN3}}
 
{{PDB Gallery|geneid=1033}}
 
{{Protein tyrosine phosphatases}}
 
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{{gene-14-stub}}

Revision as of 09:30, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.[1][2][3]

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.[3]

Interactions

CDKN3 has been shown to interact with Cyclin-dependent kinase 2,[4][5][6] Cdk1[1][5] and MS4A3.[7]

References

  1. ↑ 1.0 1.1 Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
  2. ↑ Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
  3. ↑ 3.0 3.1 "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".
  4. ↑ Yeh, Chau-Ting; Lu Su-Chuan; Chao Chung-Hao; Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. United States. 305 (2): 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075.
  5. ↑ 5.0 5.1 Hannon, G J; Casso D; Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 91 (5): 1731–5. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873.
  6. ↑ Harper, J W; Adami G R; Wei N; Keyomarsi K; Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. UNITED STATES. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751.
  7. ↑ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. United States. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350.

Further reading

External links



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