PTPN3: Difference between revisions
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)) |
m (Bot: HTTP→HTTPS (v470)) |
||
Line 1: | Line 1: | ||
< | {{Infobox_gene}} | ||
{{ | '''Tyrosine-protein phosphatase non-receptor type 3''' is an [[enzyme]] that in humans is encoded by the ''PTPN3'' [[gene]].<ref name="pmid1648725">{{cite journal | vauthors = Yang Q, Tonks NK | title = Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin | journal = Proc Natl Acad Sci USA | volume = 88 | issue = 14 | pages = 5949–53 | date = August 1991 | pmid = 1648725 | pmc = 51999 | doi = 10.1073/pnas.88.14.5949 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5774| accessdate = }}</ref> | ||
| | |||
| | |||
| | |||
}} | |||
== Function == | |||
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.<ref name="entrez" /> | |||
==References== | == Interactions == | ||
{{reflist | |||
==Further reading== | PTPN3 has been shown to [[Protein-protein interaction|interact]] with [[YWHAB]].<ref name=pmid9341175>{{cite journal | vauthors = Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK | title = Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27281–7 | date = October 1997 | pmid = 9341175 | doi = 10.1074/jbc.272.43.27281 }}</ref> | ||
== References == | |||
{{reflist}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K, Yachi A | title = cDNA cloning of new protein tyrosine phosphatases in the human colon. | journal = Tumour Biol. | volume = 13 | issue = 3 | pages = 180–6 | year = 1992 | pmid = 1626183 | doi = 10.1159/000217763 }} | |||
* {{cite journal | vauthors = Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A | title = Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma. | journal = J. Gastroenterol. | volume = 29 | issue = 6 | pages = 727–32 | year = 1995 | pmid = 7874267 | doi = 10.1007/BF02349278 }} | |||
*{{cite journal | * {{cite journal | vauthors = Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A | title = Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins. | journal = Int. J. Cancer | volume = 55 | issue = 6 | pages = 947–51 | year = 1994 | pmid = 8253532 | doi = 10.1002/ijc.2910550612 }} | ||
* {{cite journal | vauthors = Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK | title = Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27281–7 | year = 1997 | pmid = 9341175 | doi = 10.1074/jbc.272.43.27281 }} | |||
*{{cite journal | * {{cite journal | vauthors = Zhang SH, Liu J, Kobayashi R, Tonks NK | title = Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1. | journal = J. Biol. Chem. | volume = 274 | issue = 25 | pages = 17806–12 | year = 1999 | pmid = 10364224 | doi = 10.1074/jbc.274.25.17806 }} | ||
*{{cite journal | * {{cite journal | vauthors = Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T | title = Subcellular localization of intracellular protein tyrosine phosphatases in T cells. | journal = Eur. J. Immunol. | volume = 30 | issue = 8 | pages = 2412–21 | year = 2000 | pmid = 10940933 | doi = 10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J }} | ||
*{{cite journal | * {{cite journal | vauthors = Zheng Y, Schlondorff J, Blobel CP | title = Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42463–70 | year = 2003 | pmid = 12207026 | doi = 10.1074/jbc.M207459200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS | title = PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit. | journal = J. Biol. Chem. | volume = 279 | issue = 9 | pages = 7760–9 | year = 2004 | pmid = 14672952 | doi = 10.1074/jbc.M309994200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML | title = Substrate-trapping techniques in the identification of cellular PTP targets. | journal = Methods | volume = 35 | issue = 1 | pages = 44–53 | year = 2005 | pmid = 15588985 | doi = 10.1016/j.ymeth.2004.07.007 }} | ||
*{{cite journal | * {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H | title = Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. | journal = Biochem. Biophys. Res. Commun. | volume = 348 | issue = 4 | pages = 1455–62 | year = 2006 | pmid = 16930557 | doi = 10.1016/j.bbrc.2006.08.014 }} | ||
* {{cite journal | vauthors = Jing M, Bohl J, Brimer N, Kinter M, Vande Pol SB | title = Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. | journal = J. Virol. | volume = 81 | issue = 5 | pages = 2231–9 | year = 2007 | pmid = 17166906 | pmc = 1865939 | doi = 10.1128/JVI.01979-06 }} | |||
*{{cite journal | * {{cite journal | vauthors = Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G | title = Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses. | journal = J. Gen. Virol. | volume = 88 | issue = Pt 11 | pages = 2956–65 | year = 2007 | pmid = 17947517 | doi = 10.1099/vir.0.83123-0 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | {{PDB Gallery|geneid=5774}} | ||
{{ | |||
{{Protein tyrosine phosphatases}} | |||
{{gene-9-stub}} |
Latest revision as of 02:38, 27 October 2017
VALUE_ERROR (nil) | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
|
| |||||
Ensembl |
|
| |||||
UniProt |
|
| |||||
RefSeq (mRNA) |
|
| |||||
RefSeq (protein) |
|
| |||||
Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
|
Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.[1][2]
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.[2]
Interactions
PTPN3 has been shown to interact with YWHAB.[3]
References
- ↑ Yang Q, Tonks NK (August 1991). "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin". Proc Natl Acad Sci USA. 88 (14): 5949–53. doi:10.1073/pnas.88.14.5949. PMC 51999. PMID 1648725.
- ↑ 2.0 2.1 "Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3".
- ↑ Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (October 1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi:10.1074/jbc.272.43.27281. PMID 9341175.
Further reading
- Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K, Yachi A (1992). "cDNA cloning of new protein tyrosine phosphatases in the human colon". Tumour Biol. 13 (3): 180–6. doi:10.1159/000217763. PMID 1626183.
- Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A (1995). "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma". J. Gastroenterol. 29 (6): 727–32. doi:10.1007/BF02349278. PMID 7874267.
- Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A (1994). "Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins". Int. J. Cancer. 55 (6): 947–51. doi:10.1002/ijc.2910550612. PMID 8253532.
- Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. doi:10.1074/jbc.272.43.27281. PMID 9341175.
- Zhang SH, Liu J, Kobayashi R, Tonks NK (1999). "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1". J. Biol. Chem. 274 (25): 17806–12. doi:10.1074/jbc.274.25.17806. PMID 10364224.
- Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933.
- Zheng Y, Schlondorff J, Blobel CP (2003). "Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1". J. Biol. Chem. 277 (45): 42463–70. doi:10.1074/jbc.M207459200. PMID 12207026.
- Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS (2004). "PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit". J. Biol. Chem. 279 (9): 7760–9. doi:10.1074/jbc.M309994200. PMID 14672952.
- Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
- Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H (2006). "Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1". Biochem. Biophys. Res. Commun. 348 (4): 1455–62. doi:10.1016/j.bbrc.2006.08.014. PMID 16930557.
- Jing M, Bohl J, Brimer N, Kinter M, Vande Pol SB (2007). "Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins". J. Virol. 81 (5): 2231–9. doi:10.1128/JVI.01979-06. PMC 1865939. PMID 17166906.
- Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G (2007). "Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses". J. Gen. Virol. 88 (Pt 11): 2956–65. doi:10.1099/vir.0.83123-0. PMID 17947517.
This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |