EIF3K: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Eukaryotic translation initiation factor 3 subunit K''' is a [[protein]] that in humans is encoded by the ''EIF3K'' [[gene]].<ref name="pmid11042152">{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Res. | volume = 10 | issue = 10 | pages = 1546–60 | date = Nov 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}</ref><ref name="pmid14519125">{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = Eur. J. Biochem. | volume = 270 | issue = 20 | pages = 4133–9 | date = Oct 2003 | pmid = 14519125 | pmc =  | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27335| accessdate = }}</ref>
'''Eukaryotic translation initiation factor 3 subunit K''' ('''eIF3k''') is a [[protein]] that in humans is encoded by the ''EIF3K'' [[gene]].<ref name="pmid11042152">{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | display-authors = 6 | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = October 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}</ref><ref name="pmid14519125">{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = European Journal of Biochemistry | volume = 270 | issue = 20 | pages = 4133–9 | date = October 2003 | pmid = 14519125 | pmc =  | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27335| accessdate = }}</ref>


== Function ==
== Function ==


The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM]<ref name="entrez" />
The ~800 kDa [[eukaryotic initiation factor 3]] (eIF3) is the largest [[Eukaryotic initiation factors|eIF]] and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the [[Eukaryotic small ribosomal subunit (40S)|40S ribosomal subunit]] and promoting formation of the [[43S preinitiation complex]].<ref name="Mayeur_2003">{{cite journal | vauthors = Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW | title = Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 | journal = European Journal of Biochemistry | volume = 270 | issue = 20 | pages = 4133–9 | year = 2003 | pmid = 14519125 | doi = 10.1046/j.1432-1033.2003.03807.x }}</ref><ref name="entrez" />


== Interactions ==
== Interactions ==


EIF3K has been shown to [[Protein–protein interaction|interact]] with [[Cyclin D3]]<ref name=pmid15327989>{{cite journal | vauthors = Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J | title = Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3 | journal = FEBS Lett. | volume = 573 | issue = 1-3 | pages = 139–46 | date = Aug 2004 | pmid = 15327989 | doi = 10.1016/j.febslet.2004.07.071 }}</ref> and [[EIF3A]].<ref name=pmid14519125 /><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref>
eIF3k has been shown to [[Protein–protein interaction|interact]] with [[Cyclin D3]]<ref name=pmid15327989>{{cite journal | vauthors = Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J | title = Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3 | journal = FEBS Letters | volume = 573 | issue = 1–3 | pages = 139–46 | date = August 2004 | pmid = 15327989 | doi = 10.1016/j.febslet.2004.07.071 }}</ref> and [[EIF3A|eIF3a]].<ref name=pmid14519125 /><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | display-authors = 6 | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref>


== See also ==
== See also ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL | title = PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact | journal = Mol. Biol. Cell | volume = 13 | issue = 5 | pages = 1722–34 | year = 2002 | pmid = 12006665 | pmc = 111139 | doi = 10.1091/mbc.02-02-0011 }}
* {{cite journal | vauthors = Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL | title = PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact | journal = Molecular Biology of the Cell | volume = 13 | issue = 5 | pages = 1722–34 | date = May 2002 | pmid = 12006665 | pmc = 111139 | doi = 10.1091/mbc.02-02-0011 }}
* {{cite journal | vauthors = Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W | title = Crystal structure of human eIF3k, the first structure of eIF3 subunits | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34983–90 | year = 2004 | pmid = 15180986 | doi = 10.1074/jbc.M405158200 }}
* {{cite journal | vauthors = Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W | title = Crystal structure of human eIF3k, the first structure of eIF3 subunits | journal = The Journal of Biological Chemistry | volume = 279 | issue = 33 | pages = 34983–90 | date = August 2004 | pmid = 15180986 | doi = 10.1074/jbc.M405158200 }}
* {{cite journal | vauthors = Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J | title = Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3 | journal = FEBS Lett. | volume = 573 | issue = 1-3 | pages = 139–46 | year = 2004 | pmid = 15327989 | doi = 10.1016/j.febslet.2004.07.071 }}
* {{cite journal | vauthors = Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J | title = Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3 | journal = FEBS Letters | volume = 573 | issue = 1–3 | pages = 139–46 | date = August 2004 | pmid = 15327989 | doi = 10.1016/j.febslet.2004.07.071 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein–protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
{{refend}}
{{refend}}


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{{Initiation factors}}
{{Initiation factors}}


{{gene-19-stub}}
{{gene-19-stub}}

Latest revision as of 19:33, 7 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.[1][2][3]

Function

The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.[4][3]

Interactions

eIF3k has been shown to interact with Cyclin D3[5] and eIF3a.[2][6]

See also

References

  1. ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  2. ↑ 2.0 2.1 Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12".
  4. ↑ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". European Journal of Biochemistry. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
  5. ↑ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (August 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3". FEBS Letters. 573 (1–3): 139–46. doi:10.1016/j.febslet.2004.07.071. PMID 15327989.
  6. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

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