Triclofos

Triclofos

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N05CM07 (WHO)
Identifiers
IUPAC name 2,2,2-trichloroethanol dihydrogen phosphate
CAS Number	306-52-5 N 8060-81-9
PubChem CID	5563
ChemSpider	5362 Y
UNII	J712EO9048
ChEMBL	ChEMBL1201317 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C2H4Cl3O4P
Molar mass	229.383 g/mol
3D model (JSmol)	Interactive image
SMILES ClC(Cl)(Cl)COP(=O)(O)O
InChI InChI=1S/C2H4Cl3O4P/c3-2(4,5)1-9-10(6,7)8/h1H2,(H2,6,7,8) Y Key:YYQRGCZGSFRBAM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Triclofos is a sedative drug used rarely for treating insomnia, usually as a second-line treatment after other drugs have failed. Triclofos may cause dependence and should not be withdrawn suddenly. This drug should only be used for the short term relief of severe insomnia and should not be mixed with alcohol or other depressant drugs. Patients should not drive or use machinery after taking triclofos.

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. This delayed action means that the half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Side effects

Side effects may include: headache, rash, dizziness, flatulence, confusion, nightmares, dependence, diarrhoea, constipation, nausea, vomiting, abdominal pain, and ataxia.