Talbutal

Talbutal

File:Talbutal.svg
Clinical data
Synonyms	5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
ATC code	N05CA07 (WHO)
Legal status
Legal status	US: Schedule III
Identifiers
IUPAC name (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione
CAS Number	115-44-6 Y
PubChem CID	8275
DrugBank	DB00306 Y
ChemSpider	7976 Y
UNII	4YIR8202AX
ChEMBL	ChEMBL1200802 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C11H16N2O3
Molar mass	224.256 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1NC(=O)NC(=O)C1(C(C)CC)C\C=C
InChI InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16) Y Key:BJVVMKUXKQHWJK-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.

Pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl⁻ ionopore at the GABA_A receptor, increasing the duration of time for which the Cl⁻ ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.

References

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