Estazolam

Estazolam
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gloria Picoy [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Estazolam is {{{aOrAn}}} {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. Common adverse reactions include {{{adverseReactions}}}.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Estazolam FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Estazolam in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Estazolam in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Estazolam FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Estazolam in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Estazolam in pediatric patients.

Contraindications

There is limited information regarding Estazolam Contraindications in the drug label.

Warnings

There is limited information regarding Estazolam Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Estazolam Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Estazolam Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Estazolam Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Estazolam in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Estazolam in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Estazolam during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Estazolam in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Estazolam in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Estazolam in geriatric settings.

Gender

There is no FDA guidance on the use of Estazolam with respect to specific gender populations.

Race

There is no FDA guidance on the use of Estazolam with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Estazolam in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Estazolam in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Estazolam in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Estazolam in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Estazolam Administration in the drug label.

Monitoring

There is limited information regarding Estazolam Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Estazolam and IV administrations.

Overdosage

There is limited information regarding Estazolam overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Estazolam Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Estazolam Mechanism of Action in the drug label.

Structure

There is limited information regarding Estazolam Structure in the drug label.

Pharmacodynamics

There is limited information regarding Estazolam Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Estazolam Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Estazolam Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Estazolam Clinical Studies in the drug label.

How Supplied

There is limited information regarding Estazolam How Supplied in the drug label.

Storage

There is limited information regarding Estazolam Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Estazolam |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Estazolam |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Estazolam Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Estazolam interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Estazolam Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Estazolam Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Estazolam

File:Estazolam.svg
File:Estazolam3d.png
Clinical data
Pregnancy category	? (USA)
Routes of administration	Oral
ATC code	N05CD04 (WHO)
Legal status
Legal status	US: Schedule IV
Pharmacokinetic data
Bioavailability	93%
Metabolism	Hepatic
Elimination half-life	10-24 hours
Excretion	Renal
Identifiers
IUPAC name 8-Chloro-6-phenyl- 4H-1,2,4-triazolo(4,3-a)- 1,4-benzodiazepine
CAS Number	29975-16-4
PubChem CID	3261
DrugBank	APRD00955
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H11ClN4
Molar mass	294.7

Estazolam (marketed under the brand names ProSom, Eurodin) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting oral benzodiazepine.

It is commonly prescribed for short-term treatment of insomnia.

Pharmacology

Estazolam is classed as a "triazolo" benzodiazepine drug. An animal study demonstrated that estazolam induces a drowsy pattern of spontaneous EEG including high voltage slow waves and spindle bursts increase in the cortex and amygdala, while the hippocampal theta rhythm is desynchronized. Also low voltage fast waves occur particularly in the cortical EEG. The EEG arousal response to auditory stimulation and to electric stimulation of the mesencephalic reticular formation, posterior hypothalamus and centromedian thalamus is significantly suppressed. The photic driving response elicited by a flash light in the visual cortex is significantly suppressed by estazolam. Estazolam at high doses decreases histamine turnover via it's action at the benzodiazepine-GABA receptor complex.

Estazolam and other benzodiazepines may influence neurosteroid metabolism which in turn may influence the functions of the brain and reproductive system. The pharmacological actions of benzodiazepines at the GABAa receptor are similar to those of neurosteroids. Neuroactive steroids are positive allosteric modulators of the GABAa receptor, enhancing GABA function. Many hypnotic benzodiazepines (nimetazepam, temazepam, estazolam, flunitrazepam and nitrazepam) potently inhibit the enzymes involved in the metabolism of neurosteroids. Long-term administration of benzodiazepines may influence the concentrations of endogenous neurosteroids, and thereby would modulate the emotional state. Factors which effects benzodiazepines ability to alter neurosteroid levels depend on the molecular make up of the individual benzodiazepine. Presence of a substituent at N1 position of the diazepine ring and/or the chloro or nitro group at position 7 of the benzene ring contribute to potent inhibition of the isoenzymes, and in turn a bromo group at position 7 (for bromazepam) and additional substituents (3-hydroxy group for oxazepam and tetrahydroxazole ring for cloxazolam and oxazolam) decrease the inhibitory potency.

Abuse

Estazolam became notorious in 1998 when a large amount of a 'herbal sleeping mix' called Sleeping Buddha was recalled from the shelves after the FDA descovered that it contained estazolam (as well as some heavy metal salts).

See also

• Benzodiazepines
• Brotizolam
• Midazolam
• Triazolam

External links

• Flash animation about how estazolam works (mechanism of action)
• Rx-List - Estazolam
• Inchem - Estazolam

Template:Pharma-stub sv:Estazolam