Interleukin-1 receptor
| interleukin 1 receptor, type I | |
|---|---|
| Identifiers | |
| Symbol | IL1R1 |
| Alt. symbols | IL1R, IL1RA |
| Entrez | 3554 |
| HUGO | 5993 |
| OMIM | 147810 |
| RefSeq | NM_000877 |
| UniProt | P14778 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor, type II | |
|---|---|
| Identifiers | |
| Symbol | IL1R2 |
| Alt. symbols | IL1RB |
| Entrez | 7850 |
| HUGO | 5994 |
| OMIM | 147811 |
| RefSeq | NM_173343 |
| UniProt | P27930 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor accessory protein | |
|---|---|
| Identifiers | |
| Symbol | IL1RAP |
| Alt. symbols | IL-1RAcP, IL1R3, C3orf13 |
| Entrez | 3556 |
| HUGO | 5995 |
| OMIM | 602626 |
| RefSeq | NM_134470 |
| UniProt | Q9NPH3 |
| Other data | |
| Locus | Chr. 3 q28 |
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
References
- ↑ 1.0 1.1 Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161.
- ↑ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
- ↑ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External links
- Receptors,+Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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