KCNK1

Potassium channel, subfamily K, member 1
Identifiers
Symbols	KCNK1 ; DPK; HOHO; K2p1.1; TWIK-1; TWIK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1691
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Potassium channel, subfamily K, member 1, also known as KCNK1, is a human gene.

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.

See also

• Tandem pore domain potassium channel

Further reading

• Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily". J. Mol. Med. 76 (1): 13–20. PMID 9462864.CS1 maint: Multiple names: authors list (link)
• Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. Renal Physiol. 279 (5): F793–801. PMID 11053038.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078.CS1 maint: Multiple names: authors list (link)
• Goldstein SA, Bayliss DA, Kim D; et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lesage F, Guillemare E, Fink M; et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure". EMBO J. 15 (5): 1004–11. PMID 8605869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lesage F, Mattéi M, Fink M; et al. (1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. PMID 8661042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lesage F, Reyes R, Fink M; et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge". EMBO J. 15 (23): 6400–7. PMID 8978667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orias M, Velázquez H, Tung F; et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments". Am. J. Physiol. 273 (4 Pt 2): F663–6. PMID 9362344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Z, Yue L, White M; et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle". Circulation. 98 (22): 2422–8. PMID 9832487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Medhurst AD, Rennie G, Chapman CG; et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. PMID 11165377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear". Hear. Res. 181 (1–2): 20–6. PMID 12855359.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajan S, Plant LD, Rabin ML; et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1". Cell. 121 (1): 37–47. doi:10.1016/j.cell.2005.01.019. PMID 15820677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KCNK1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.