Nav1.2

Sodium channel, voltage-gated, type II, alpha subunit
File:PBB Protein SCN2A image.jpg PDB rendering based on 1byy.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1byy​
Identifiers
Symbols	SCN2A ; HBSCI; SCN2A1; HBA; HBSCII; Na(v)1.2; Nav1.2; SCN2A2
External IDs	Template:OMIM5 HomoloGene: 75001
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SCN2A 206381 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Na_vα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a human protein encoded by the SCN2A gene. Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain the Na_vα1.2 subunit are called Na_v1.2 channels.

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

See also

• Sodium channel

Further reading

• Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.CS1 maint: Multiple names: authors list (link)
• Lu CM, Han J, Rado TA, Brown GB (1992). "Differential expression of two sodium channel subtypes in human brain". FEBS Lett. 303 (1): 53–8. PMID 1317301.CS1 maint: Multiple names: authors list (link)
• Ahmed CM, Ware DH, Lee SC; et al. (1992). "Primary structure, chromosomal localization, and functional expression of a voltage-gated sodium channel from human brain". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8220–4. PMID 1325650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han JA, Lu CM, Brown GB, Rado TA (1991). "Direct amplification of a single dissected chromosomal segment by polymerase chain reaction: a human brain sodium channel gene is on chromosome 2q22-q23". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 335–9. PMID 1846440.CS1 maint: Multiple names: authors list (link)
• Litt M, Luty J, Kwak M; et al. (1989). "Localization of a human brain sodium channel gene (SCN2A) to chromosome 2". Genomics. 5 (2): 204–8. PMID 2571571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Lu CM, Eichelberger JS, Beckman ML; et al. (1999). "Isolation of the 5'-flanking region for human brain sodium channel subtype II alpha-subunit". J. Mol. Neurosci. 11 (3): 179–82. PMID 10344788.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baulac S, Gourfinkel-An I, Picard F; et al. (2000). "A second locus for familial generalized epilepsy with febrile seizures plus maps to chromosome 2q21-q33". Am. J. Hum. Genet. 65 (4): 1078–85. PMID 10486327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schade SD, Brown GB (2001). "Identifying the promoter region of the human brain sodium channel subtype II gene (SCN2A)". Brain Res. Mol. Brain Res. 81 (1–2): 187–90. PMID 11000491.
• Kasai N, Fukushima K, Ueki Y; et al. (2001). "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus". Gene. 264 (1): 113–22. PMID 11245985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malacarne M, Gennaro E, Madia F; et al. (2001). "Benign familial infantile convulsions: mapping of a novel locus on chromosome 2q24 and evidence for genetic heterogeneity". Am. J. Hum. Genet. 68 (6): 1521–6. PMID 11326335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugawara T, Tsurubuchi Y, Agarwala KL; et al. (2001). "A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6384–9. doi:10.1073/pnas.111065098. PMID 11371648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heron SE, Crossland KM, Andermann E; et al. (2002). "Sodium-channel defects in benign familial neonatal-infantile seizures". Lancet. 360 (9336): 851–2. PMID 12243921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weiss LA, Escayg A, Kearney JA; et al. (2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry. 8 (2): 186–94. doi:10.1038/sj.mp.4001241. PMID 12610651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu FH, Westenbroek RE, Silos-Santiago I; et al. (2003). "Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2". J. Neurosci. 23 (20): 7577–85. PMID 12930796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McEwen DP, Meadows LS, Chen C; et al. (2004). "Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin". J. Biol. Chem. 279 (16): 16044–9. doi:10.1074/jbc.M400856200. PMID 14761957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamiya K, Kaneda M, Sugawara T; et al. (2004). "A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline". J. Neurosci. 24 (11): 2690–8. doi:10.1523/JNEUROSCI.3089-03.2004. PMID 15028761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berkovic SF, Heron SE, Giordano L; et al. (2004). "Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy". Ann. Neurol. 55 (4): 550–7. doi:10.1002/ana.20029. PMID 15048894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pereira S, Vieira JP, Barroca F; et al. (2004). "Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A". Neurology. 63 (1): 191–2. PMID 15249644.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• SCN2A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.