KCNIP2
Kv channel interacting protein 2 | |||||||||||
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Identifiers | |||||||||||
Symbols | KCNIP2 ; DKFZp566L1246; KCHIP2; MGC17241 | ||||||||||
External IDs | Template:OMIM5 HomoloGene: 23710 | ||||||||||
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RNA expression pattern | |||||||||||
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Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
Kv channel interacting protein 2, also known as KCNIP2, is a human gene.[1]
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.[1]
See also
References
Further reading
- An WF, Bowlby MR, Betty M; et al. (2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Ohya S, Morohashi Y, Muraki K; et al. (2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochem. Biophys. Res. Commun. 282 (1): 96–102. doi:10.1006/bbrc.2001.4558. PMID 11263977.
- Bähring R, Dannenberg J, Peters HC; et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421.
- Rosati B, Pan Z, Lypen S; et al. (2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle". J. Physiol. (Lond.). 533 (Pt 1): 119–25. PMID 11351020.
- Decher N, Uyguner O, Scherer CR; et al. (2002). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant". Cardiovasc. Res. 52 (2): 255–64. PMID 11684073.
- Kuo HC, Cheng CF, Clark RB; et al. (2002). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia". Cell. 107 (6): 801–13. PMID 11747815.
- Deschênes I, DiSilvestre D, Juang GJ; et al. (2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation. 106 (4): 423–9. PMID 12135940.
- Deschênes I, Tomaselli GF (2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Lett. 528 (1–3): 183–8. PMID 12297301.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Shibata R, Misonou H, Campomanes CR; et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.
- Ren X, Shand SH, Takimoto K (2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". J. Biol. Chem. 278 (44): 43564–70. doi:10.1074/jbc.M302337200. PMID 12928444.
- Kim LA, Furst J, Butler MH; et al. (2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2". J. Biol. Chem. 279 (7): 5549–54. doi:10.1074/jbc.M311332200. PMID 14623880.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kim LA, Furst J, Gutierrez D; et al. (2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution". Neuron. 41 (4): 513–9. PMID 14980201.
- Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
- Rhodes KJ, Carroll KI, Sung MA; et al. (2005). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain". J. Neurosci. 24 (36): 7903–15. doi:10.1523/JNEUROSCI.0776-04.2004. PMID 15356203.
- Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
External links
- KCNIP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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