HCN4

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4
File:PBB Protein HCN4 image.jpg PDB rendering based on 1q3e.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q3e​, 1q43​, 1q5o​
Identifiers
Symbols	HCN4 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3997
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4, also known as HCN4, is a human gene.

See also

• Cyclic nucleotide-gated ion channel

Further reading

• Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.CS1 maint: Multiple names: authors list (link)
• Ludwig A, Zong X, Stieber J; et al. (1999). "Two pacemaker channels from human heart with profoundly different activation kinetics". EMBO J. 18 (9): 2323–9. doi:10.1093/emboj/18.9.2323. PMID 10228147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seifert R, Scholten A, Gauss R; et al. (1999). "Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9391–6. PMID 10430953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qu J, Altomare C, Bucchi A; et al. (2003). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflugers Arch. 444 (5): 597–601. doi:10.1007/s00424-002-0860-7. PMID 12194012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schulze-Bahr E, Neu A, Friederich P; et al. (2003). "Pacemaker channel dysfunction in a patient with sinus node disease". J. Clin. Invest. 111 (10): 1537–45. PMID 12750403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stieber J, Thomer A, Much B; et al. (2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4". J. Biol. Chem. 278 (36): 33672–80. doi:10.1074/jbc.M305318200. PMID 12813043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Decher N, Bundis F, Vajna R, Steinmeyer K (2004). "KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents". Pflugers Arch. 446 (6): 633–40. doi:10.1007/s00424-003-1127-7. PMID 12856183.CS1 maint: Multiple names: authors list (link)
• Much B, Wahl-Schott C, Zong X; et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueda K, Nakamura K, Hayashi T; et al. (2004). "Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia". J. Biol. Chem. 279 (26): 27194–8. doi:10.1074/jbc.M311953200. PMID 15123648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michels G, Er F, Khan I; et al. (2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". Circulation. 111 (4): 399–404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D (2006). "Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel". N. Engl. J. Med. 354 (2): 151–7. doi:10.1056/NEJMoa052475. PMID 16407510.CS1 maint: Multiple names: authors list (link)
• Elinder F, Männikkö R, Pandey S, Larsson HP (2006). "Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels". J. Physiol. (Lond.). 575 (Pt 2): 417–31. doi:10.1113/jphysiol.2006.110437. PMID 16777944.CS1 maint: Multiple names: authors list (link)
• Nof E, Luria D, Brass D; et al. (2007). "Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia". Circulation. 116 (5): 463–70. doi:10.1161/CIRCULATIONAHA.107.706887. PMID 17646576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HCN4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.