KCNJ12

Potassium inwardly-rectifying channel, subfamily J, member 12
Identifiers
Symbols	KCNJ12 ; IRK2; KCNJN1; Kir2.2; Kir2.2v; hIRK; hIRK1; hkir2.2x; kcnj12x
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7793
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Potassium inwardly-rectifying channel, subfamily J, member 12, also known as KCNJ12 or K_ir2.2, is a human gene.

This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE; et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mukherjee A, Varma SK, Natarajan K (1972). "Ankle joint instability in poliomyelitis". Indian journal of pediatrics. 39 (289): 37–8. PMID 5024025.CS1 maint: Multiple names: authors list (link)
• Wible BA, De Biasi M, Majumder K; et al. (1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circ. Res. 76 (3): 343–50. PMID 7859381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Namba N, Inagaki N, Gonoi T; et al. (1996). "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2". FEBS Lett. 386 (2–3): 211–4. PMID 8647284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hugnot JP, Pedeutour F, Le Calvez C; et al. (1997). "The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism". Genomics. 39 (1): 113–6. doi:10.1006/geno.1996.4450. PMID 9027495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gallagher PG, Forget BG (1998). "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene". J. Biol. Chem. 273 (3): 1339–48. PMID 9430667.
• Namba N, Mori R, Tanaka H; et al. (1998). "The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1". Cytogenet. Cell Genet. 79 (1–2): 85–7. PMID 9533018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonoudakis D, Mailliard W, Wingerd K; et al. (2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell. Sci. 114 (Pt 5): 987–98. PMID 11181181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Preisig-Müller R, Schlichthörl G, Goerge T; et al. (2002). "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7774–9. doi:10.1073/pnas.102609499. PMID 12032359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen L, Kawano T, Bajic S; et al. (2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8430–5. doi:10.1073/pnas.122682899. PMID 12034888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaibara M, Ishihara K, Doi Y; et al. (2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Lett. 531 (2): 250–4. PMID 12417321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karkanis T, Li S, Pickering JG, Sims SM (2003). "Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery". Am. J. Physiol. Heart Circ. Physiol. 284 (6): H2325–34. doi:10.1152/ajpheart.00559.2002. PMID 12598232.CS1 maint: Multiple names: authors list (link)
• Stonehouse AH, Grubb BD, Pringle JH; et al. (2003). "Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies". J. Mol. Neurosci. 20 (2): 189–94. PMID 12794312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonoudakis D, Conti LR, Radeke CM; et al. (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leonoudakis D, Conti LR, Anderson S; et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang Y, Schram G, Romanenko VG; et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiesecker C, Zitron E, Scherer D; et al. (2006). "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1". J. Mol. Med. 84 (1): 46–56. doi:10.1007/s00109-005-0707-8. PMID 16258766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• Kir2.2+channel at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.