HCN2

Hyperpolarization activated cyclic nucleotide-gated potassium channel 2
PDB rendering based on 1q3e.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q3e​, 1q43​, 1q5o​
Identifiers
Symbols	HCN2 ; BCNG-2; BCNG2; HAC-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31022
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hyperpolarization activated cyclic nucleotide-gated potassium channel 2, also known as HCN2, is a human gene.

See also

• Cyclic nucleotide-gated ion channel

Further reading

• Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.CS1 maint: Multiple names: authors list (link)
• Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. PMID 9405696.CS1 maint: Multiple names: authors list (link)
• Santoro B, Liu DT, Yao H; et al. (1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–29. PMID 9630217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleiderlein JJ, Nisson PE, Jessee J; et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. PMID 9921901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ludwig A, Zong X, Stieber J; et al. (1999). "Two pacemaker channels from human heart with profoundly different activation kinetics". EMBO J. 18 (9): 2323–9. doi:10.1093/emboj/18.9.2323. PMID 10228147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vaccari T, Moroni A, Rocchi M; et al. (1999). "The human gene coding for HCN2, a pacemaker channel of the heart". Biochim. Biophys. Acta. 1446 (3): 419–25. PMID 10524219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Ulens C, Tytgat J (2001). "Functional heteromerization of HCN1 and HCN2 pacemaker channels". J. Biol. Chem. 276 (9): 6069–72. doi:10.1074/jbc.C000738200. PMID 11133998.
• Proenza C, Tran N, Angoli D; et al. (2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". J. Biol. Chem. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qu J, Altomare C, Bucchi A; et al. (2003). "Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells". Pflugers Arch. 444 (5): 597–601. doi:10.1007/s00424-002-0860-7. PMID 12194012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sesti F, Rajan S, Gonzalez-Colaso R; et al. (2003). "Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel". Nat. Neurosci. 6 (4): 353–61. doi:10.1038/nn1028. PMID 12640457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stieber J, Thomer A, Much B; et al. (2003). "Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4". J. Biol. Chem. 278 (36): 33672–80. doi:10.1074/jbc.M305318200. PMID 12813043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bender RA, Soleymani SV, Brewster AL; et al. (2003). "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus". J. Neurosci. 23 (17): 6826–36. PMID 12890777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Much B, Wahl-Schott C, Zong X; et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michels G, Er F, Khan I; et al. (2005). "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". Circulation. 111 (4): 399–404. doi:10.1161/01.CIR.0000153799.65783.3A. PMID 15687126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akhavan A, Atanasiu R, Noguchi T; et al. (2005). "Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization". J. Cell. Sci. 118 (Pt 13): 2803–12. doi:10.1242/jcs.02423. PMID 15961404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Calloe K, Elmedyb P, Olesen SP; et al. (2006). "Hypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels". Biophys. J. 89 (3): 2159–69. doi:10.1529/biophysj.105.063792. PMID 15980171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• HCN2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.