Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1gene.[1] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[2][3][4]
Genetic knockout and pharmacological inhibition experiments demonstrate that Two-pore Channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.[7]
↑Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (October 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID10574461.
↑Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID10753632.
↑Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID16382101.
Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID10753632.
Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (October 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID10574461.
Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID16382101.