Dermoid cyst pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Dermoid cyst is a mature cystic teratoma that arises from the totipotent germ cells and are generally formed of skin, hair follicles, and sweat glands, although they may include clumps of long hair, pockets of sebum, blood, fat, bone, nails, teeth, eyes, cartilage, and thyroid tissue.[1]


Pathophysiology

  • Dermoid cyst is a cystic teratoma that arises from the totipotent germ cells and are generally formed of skin, hair follicles, and sweat glands, although they may include clumps of long hair, pockets of sebum, blood, fat, bone, nails, teeth, eyes, cartilage, and thyroid tissue.[2]
  • The totipotent germ cells differentiate abnormally and develop characteristics of mature dermal cells.
  • Dermoid cysts predominantly have ectodermal derivatives.[3]

Gross pathology

  • On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.[4]

References

  1. Dermoid cyst. Wikipedia.https://en.wikipedia.org/wiki/Dermoid_cyst. Accessed on February 2, 2016
  2. Dermoid cyst. Wikipedia.https://en.wikipedia.org/wiki/Dermoid_cyst. Accessed on February 2, 2016
  3. Elsheikh, Tarik (2002), Dermoid Cyst (Mature Cystic Teratoma) of the Cecum, Muncie, IN: Archives of Pathology & Laboratory Medicine, p. 97-99, retrieved February 2, 2016
  4. Joseph Schuetz, Tarik (2002), Dermoid Cyst (Mature Cystic Teratoma) of the Cecum, Muncie, IN: Archives of Pathology & Laboratory Medicine, p. 97-99, retrieved February 2, 2016


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