ITPR2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
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Wikidata
View/Edit Human

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

See also

• Inositol trisphosphate receptor

Further reading

• Jardín I, Lápez JJ, Salido GM, Rosado JA (2008). "Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets". Cell. Signal. 20 (4): 737–47. doi:10.1016/j.cellsig.2007.12.010. PMID 18249094.
• Wilker E, Mittleman MA, Litonjua AA, et al. (2009). "Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter". Environ. Health Perspect. 117 (6): 935–40. doi:10.1289/ehp.0800279. PMC 2702409. PMID 19590686.
• Rosado JA, Sage SO (2001). "Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets". Biochem. J. 356 (Pt 1): 191–8. doi:10.1042/0264-6021:3560191. PMC 1221827. PMID 11336651.
• van Es MA, Van Vught PW, Blauw HM, et al. (2007). "ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study". Lancet Neurology. 6 (10): 869–77. doi:10.1016/S1474-4422(07)70222-3. PMID 17827064.
• Harzheim D, Movassagh M, Foo RS, et al. (2009). "Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy". Proc. Natl. Acad. Sci. U.S.A. 106 (27): 11406–11. doi:10.1073/pnas.0905485106. PMC 2708695. PMID 19549843.
• Rosado JA, Sage SO (2000). "Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted". Biochem. J. 350 Pt 3: 631–5. doi:10.1042/0264-6021:3500631. PMC 1221291. PMID 10970773.
• Uhl GR, Liu QR, Drgon T, et al. (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.
• Chiò A, Schymick JC, Restagno G, et al. (2009). "A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis". Hum. Mol. Genet. 18 (8): 1524–32. doi:10.1093/hmg/ddp059. PMC 2664150. PMID 19193627.
• Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol. 17 (2): 137–43. doi:10.1007/s10165-006-0555-6. PMID 17437169.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mery L, Magnino F, Schmidt K, et al. (2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Lett. 487 (3): 377–83. doi:10.1016/S0014-5793(00)02362-0. PMID 11163362.
• Diaz F, Bourguignon LY (2000). "Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells". Cell Calcium. 27 (6): 315–28. doi:10.1054/ceca.2000.0126. PMID 11013462.
• Mayne M, Holden CP, Nath A, Geiger JD (2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". J. Immunol. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
• Tanimura A, Tojyo Y, Turner RJ (2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". J. Biol. Chem. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.
• Jurkovicova D, Sedlakova B, Lacinova L, et al. (2008). "Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line". Ann. N. Y. Acad. Sci. 1148: 421–7. doi:10.1196/annals.1410.034. PMID 19120137.
• Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI (2002). "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling". J. Biol. Chem. 277 (2): 1340–8. doi:10.1074/jbc.M106609200. PMID 11694504.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Tovey SC, Dedos SG, Taylor EJ, et al. (2008). "Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP". J. Cell Biol. 183 (2): 297–311. doi:10.1083/jcb.200803172. PMC 2568025. PMID 18936250.
• Johnson JM, Castle J, Garrett-Engele P, et al. (2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.

External links

• ITPR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)