CACNB1

Calcium channel, voltage-dependent, beta 1 subunit
PDB rendering based on 1t0h.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1t0h​, 1t0j​
Identifiers
Symbols	CACNB1 ; CAB1; CACNLB1; CCHLB1; MGC41896
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20186
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Calcium channel, voltage-dependent, beta 1 subunit, also known as CACNB1, is a human gene.

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

See also

• Voltage-dependent calcium channel

Further reading

• Williams ME, Feldman DH, McCue AF; et al. (1992). "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype". Neuron. 8 (1): 71–84. PMID 1309651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perez-Reyes E, Castellano A, Kim HS; et al. (1992). "Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel". J. Biol. Chem. 267 (3): 1792–7. PMID 1370480.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powers PA, Liu S, Hogan K, Gregg RG (1992). "Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene". J. Biol. Chem. 267 (32): 22967–72. PMID 1385409.CS1 maint: Multiple names: authors list (link)
• Pragnell M, Sakamoto J, Jay SD, Campbell KP (1991). "Cloning and tissue-specific expression of the brain calcium channel beta-subunit". FEBS Lett. 291 (2): 253–8. PMID 1657644.CS1 maint: Multiple names: authors list (link)
• Collin T, Wang JJ, Nargeot J, Schwartz A (1993). "Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart". Circ. Res. 72 (6): 1337–44. PMID 7916667.CS1 maint: Multiple names: authors list (link)
• Gregg RG, Powers PA, Hogan K (1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping". Genomics. 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767.CS1 maint: Multiple names: authors list (link)
• Iles DE, Segers B, Sengers RC; et al. (1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum. Mol. Genet. 2 (7): 863–8. PMID 8395940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuda K, Kaneko S, Yada N; et al. (1997). "Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes". Neurosci. Lett. 217 (1): 13–6. PMID 8905728.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregg RG, Messing A, Strube C; et al. (1997). "Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13961–6. PMID 8943043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brice NL, Dolphin AC (1999). "Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line". J. Physiol. (Lond.). 515 ( Pt 3): 685–94. PMID 10066897.
• Lie AA, Blümcke I, Volsen SG; et al. (1999). "Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy". Neuroscience. 93 (2): 449–56. PMID 10465427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hogan K, Greg RG, Powers PA (2000). "Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels". Neurosci. Lett. 277 (2): 111–4. PMID 10624822.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finlin BS, Crump SM, Satin J, Andres DA (2004). "Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 14469–74. doi:10.1073/pnas.2437756100. PMID 14623965.CS1 maint: Multiple names: authors list (link)
• Navarro-Lérida I, Martínez Moreno M, Roncal F; et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foell JD, Balijepalli RC, Delisle BP; et al. (2004). "Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization". Physiol. Genomics. 17 (2): 183–200. doi:10.1152/physiolgenomics.00207.2003. PMID 14762176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CACNB1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.