Chloride potassium symporter 5

Solute carrier family 12, (potassium-chloride transporter) member 5
Identifiers
Symbols	SLC12A5 ; KCC2; KIAA1176
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10665
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

potassium-chloride transporter member 5 is a type of chloride potassium symporter.

This potassium-chloride transporter is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons.

It is encoded by the gene SLC12A5, is a human gene.

See also

• Solute carrier family

Further reading

• Hebert SC, Mount DB, Gamba G (2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family". Pflugers Arch. 447 (5): 580–93. doi:10.1007/s00424-003-1066-3. PMID 12739168.CS1 maint: Multiple names: authors list (link)
• Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII". J. Physiol. (Lond.). 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMID 15528236.CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirosawa M, Nagase T, Ishikawa K; et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. PMID 10574461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hübner CA, Stein V, Hermans-Borgmeyer I; et al. (2001). "Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition". Neuron. 30 (2): 515–24. PMID 11395011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sallinen R, Tornberg J, Putkiranta M; et al. (2001). "Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology". Cytogenet. Cell Genet. 94 (1–2): 67–70. PMID 11701957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song L, Mercado A, Vázquez N; et al. (2002). "Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter". Brain Res. Mol. Brain Res. 103 (1–2): 91–105. PMID 12106695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bräuer M, Frei E, Claes L; et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee H, Chen CX, Liu YJ; et al. (2005). "KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses". Eur. J. Neurosci. 21 (9): 2593–9. doi:10.1111/j.1460-9568.2005.04084.x. PMID 15932617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mercado A, Broumand V, Zandi-Nejad K; et al. (2006). "A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport". J. Biol. Chem. 281 (2): 1016–26. doi:10.1074/jbc.M509972200. PMID 16291749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vanhatalo S, Palva JM, Andersson S; et al. (2006). "Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex". Eur. J. Neurosci. 22 (11): 2799–804. doi:10.1111/j.1460-9568.2005.04459.x. PMID 16324114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee HH, Walker JA, Williams JR; et al. (2007). "Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2". J. Biol. Chem. 282 (41): 29777–84. doi:10.1074/jbc.M705053200. PMID 17693402.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uvarov P, Ludwig A, Markkanen M; et al. (2007). "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2". J. Biol. Chem. 282 (42): 30570–6. doi:10.1074/jbc.M705095200. PMID 17715129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.