Cyclin-dependent kinase 7

Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
PDB rendering based on 1ua2.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ua2​
Identifiers
Symbols	CDK7 ; CAK1; CDKN7; STK1; p39MO15
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1363
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), also known as CDK7, is a human gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

See also

• Cyclin-dependent kinase

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. PMID 9570510.
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. PMID 9651670.
• Shiekhattar R, Mermelstein F, Fisher RP; et al. (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature. 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aprelikova O, Xiong Y, Liu ET (1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". J. Biol. Chem. 270 (31): 18195–7. PMID 7629134.CS1 maint: Multiple names: authors list (link)
• Serizawa H, Mäkelä TP, Conaway JW; et al. (1995). "Association of Cdk-activating kinase subunits with transcription factor TFIIH". Nature. 374 (6519): 280–2. doi:10.1038/374280a0. PMID 7885450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tassan JP, Schultz SJ, Bartek J, Nigg EA (1994). "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)". J. Cell Biol. 127 (2): 467–78. PMID 7929589.CS1 maint: Multiple names: authors list (link)
• Darbon JM, Devault A, Taviaux S; et al. (1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene. 9 (11): 3127–38. PMID 7936635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams RT, Wu L, Carbonaro-Hall DA, Hall FL (1994). "Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells". Arch. Biochem. Biophys. 314 (1): 99–106. PMID 7944411.CS1 maint: Multiple names: authors list (link)
• Fisher RP, Morgan DO (1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell. 78 (4): 713–24. PMID 8069918.
• Mäkelä TP, Tassan JP, Nigg EA; et al. (1994). "A cyclin associated with the CDK-activating kinase MO15". Nature. 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Levedakou EN, He M, Baptist EW; et al. (1994). "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern". Oncogene. 9 (7): 1977–88. PMID 8208544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu L, Yee A, Liu L; et al. (1994). "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase". Oncogene. 9 (7): 2089–96. PMID 8208556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yee A, Nichols MA, Wu L; et al. (1996). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blau J, Xiao H, McCracken S; et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. PMID 8628270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bartkova J, Zemanova M, Bartek J (1996). "Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation". Int. J. Cancer. 66 (6): 732–7. doi:10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO;2-0. PMID 8647641.CS1 maint: Multiple names: authors list (link)
• Reardon JT, Ge H, Gibbs E; et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. PMID 8692841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drapkin R, Le Roy G, Cho H; et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. PMID 8692842.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. PMID 8849451.
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature. 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526.
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383.CS1 maint: Multiple names: authors list (link)

External links

• CDK7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)