Cyclin-dependent kinase 8

Cyclin-dependent kinase 8
Identifiers
Symbols	CDK8 ; K35; MGC126074; MGC126075
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55565
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cyclin-dependent kinase 8, also known as CDK8, is a human gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Further reading

• Tassan JP, Jaquenoud M, Léopold P; et al. (1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8871–5. PMID 7568034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
• Rickert P, Seghezzi W, Shanahan F; et al. (1996). "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II". Oncogene. 12 (12): 2631–40. PMID 8700522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cujec TP, Cho H, Maldonado E; et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. PMID 9121429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scully R, Anderson SF, Chao DM; et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. PMID 9159119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neish AS, Anderson SF, Schlegel BP; et al. (1998). "Factors associated with the mammalian RNA polymerase II holoenzyme". Nucleic Acids Res. 26 (3): 847–53. PMID 9443979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cho H, Orphanides G, Sun X; et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun X, Zhang Y, Cho H; et al. (1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell. 2 (2): 213–22. PMID 9734358.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rickert P, Corden JL, Lees E (1999). "Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases". Oncogene. 18 (4): 1093–102. doi:10.1038/sj.onc.1202399. PMID 10023686.CS1 maint: Multiple names: authors list (link)
• Gu W, Malik S, Ito M; et al. (1999). "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation". Mol. Cell. 3 (1): 97–108. PMID 10024883.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Yuan CX, Malik S; et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. PMID 10198638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rachez C, Lemon BD, Suldan Z; et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akoulitchev S, Chuikov S, Reinberg D (2000). "TFIIH is negatively regulated by cdk8-containing mediator complexes". Nature. 407 (6800): 102–6. doi:10.1038/35024111. PMID 10993082.CS1 maint: Multiple names: authors list (link)
• Ramanathan Y, Rajpara SM, Reza SM; et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang G, Cantin GT, Stevens JL, Berk AJ (2001). "Characterization of mediator complexes from HeLa cell nuclear extract". Mol. Cell. Biol. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. PMID 11416138.CS1 maint: Multiple names: authors list (link)
• Di Pietro C, Rapisarda A, Bonaiuto C; et al. (2001). "Genomics of the human genes encoding four TAFII subunits of TFIID, the three subunits of TFIIA, as well as CDK8 and SURB7". Somat. Cell Mol. Genet. 25 (3): 185–9. PMID 11441538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vogel L, Baratte B, Détivaud L; et al. (2002). "Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein". Biochim. Biophys. Acta. 1589 (2): 219–31. PMID 12007796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crowley TE, Kaine EM, Yoshida M; et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. PMID 12145330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato S, Tomomori-Sato C, Banks CA; et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CDK8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)