KCNIP2

Kv channel interacting protein 2
Identifiers
Symbols	KCNIP2 ; DKFZp566L1246; KCHIP2; MGC17241
External IDs	Template:OMIM5 HomoloGene: 23710
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kv channel interacting protein 2, also known as KCNIP2, is a human gene.

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.

See also

• Voltage-gated potassium channel

Further reading

• An WF, Bowlby MR, Betty M; et al. (2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohya S, Morohashi Y, Muraki K; et al. (2001). "Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2". Biochem. Biophys. Res. Commun. 282 (1): 96–102. doi:10.1006/bbrc.2001.4558. PMID 11263977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bähring R, Dannenberg J, Peters HC; et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–94. doi:10.1074/jbc.M101320200. PMID 11287421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosati B, Pan Z, Lypen S; et al. (2001). "Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle". J. Physiol. (Lond.). 533 (Pt 1): 119–25. PMID 11351020.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Decher N, Uyguner O, Scherer CR; et al. (2002). "hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant". Cardiovasc. Res. 52 (2): 255–64. PMID 11684073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuo HC, Cheng CF, Clark RB; et al. (2002). "A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia". Cell. 107 (6): 801–13. PMID 11747815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deschênes I, DiSilvestre D, Juang GJ; et al. (2002). "Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?". Circulation. 106 (4): 423–9. PMID 12135940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deschênes I, Tomaselli GF (2002). "Modulation of Kv4.3 current by accessory subunits". FEBS Lett. 528 (1–3): 183–8. PMID 12297301.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibata R, Misonou H, Campomanes CR; et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–54. doi:10.1074/jbc.M306142200. PMID 12829703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren X, Shand SH, Takimoto K (2003). "Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide". J. Biol. Chem. 278 (44): 43564–70. doi:10.1074/jbc.M302337200. PMID 12928444.CS1 maint: Multiple names: authors list (link)
• Kim LA, Furst J, Butler MH; et al. (2004). "Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2". J. Biol. Chem. 279 (7): 5549–54. doi:10.1074/jbc.M311332200. PMID 14623880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim LA, Furst J, Gutierrez D; et al. (2004). "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution". Neuron. 41 (4): 513–9. PMID 14980201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.CS1 maint: Multiple names: authors list (link)
• Rhodes KJ, Carroll KI, Sung MA; et al. (2005). "KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain". J. Neurosci. 24 (36): 7903–15. doi:10.1523/JNEUROSCI.0776-04.2004. PMID 15356203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–10. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• KCNIP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.