KCNJ5
| Potassium inwardly-rectifying channel, subfamily J, member 5 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KCNJ5 ; CIR; GIRK4; KATP1; KIR3.4 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20248 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (protein) | n/a | n/a | |||||||||
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Potassium inwardly-rectifying channel, subfamily J, member 5, also known as KCNJ5 or Kir3.4, is a human gene.[1]
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.[1]
See also
References
Further reading
- Zhuo ML, Huang Y, Liu DP, Liang CC (2005). "KATP channel: relation with cell metabolism and role in the cardiovascular system". Int. J. Biochem. Cell Biol. 37 (4): 751–64. doi:10.1016/j.biocel.2004.10.008. PMID 15694835.
- Kubo Y, Adelman JP, Clapham DE; et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
- Tucker SJ, James MR, Adelman JP (1995). "Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24". Genomics. 28 (1): 127–8. doi:10.1006/geno.1995.1121. PMID 7590741.
- Ashford ML, Bond CT, Blair TA, Adelman JP (1994). "Cloning and functional expression of a rat heart KATP channel". Nature. 370 (6489): 456–9. doi:10.1038/370456a0. PMID 8047164.
- Ashford ML, Bond CT, Blair TA, Adelman JP (1996). "Cloning and functional expression of a rat heart KATP channel". Nature. 378 (6559): 792. doi:10.1038/378792a0. PMID 8524415.
- Spauschus A, Lentes KU, Wischmeyer E; et al. (1996). "A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels". J. Neurosci. 16 (3): 930–8. PMID 8558261.
- Iizuka M, Kubo Y, Tsunenari I; et al. (1996). "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel". Recept. Channels. 3 (4): 299–315. PMID 8834003.
- Chan KW, Langan MN, Sui JL; et al. (1996). "A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins". J. Gen. Physiol. 107 (3): 381–97. PMID 8868049.
- Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8. PMID 9108307.
- Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein". J. Biol. Chem. 272 (23): 14733–9. PMID 9169438.
- Wischmeyer E, Döring F, Wischmeyer E; et al. (1997). "Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels". Mol. Cell. Neurosci. 9 (3): 194–206. doi:10.1006/mcne.1997.0614. PMID 9245502.
- Krapivinsky G, Kennedy ME, Nemec J; et al. (1998). "Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation". J. Biol. Chem. 273 (27): 16946–52. PMID 9642257.
- Corey S, Clapham DE (1998). "Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers". J. Biol. Chem. 273 (42): 27499–504. PMID 9765280.
- Kennedy ME, Nemec J, Corey S; et al. (1999). "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels". J. Biol. Chem. 274 (4): 2571–82. PMID 9891030.
- Schoots O, Wilson JM, Ethier N; et al. (2000). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cell. Signal. 11 (12): 871–83. PMID 10659995.
- He C, Yan X, Zhang H; et al. (2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". J. Biol. Chem. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.
- Ma D, Zerangue N, Raab-Graham K; et al. (2002). "Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart". Neuron. 33 (5): 715–29. PMID 11879649.
- Lavine N, Ethier N, Oak JN; et al. (2003). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. Chem. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Shankar H, Murugappan S, Kim S; et al. (2004). "Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses". Blood. 104 (5): 1335–43. doi:10.1182/blood-2004-01-0069. PMID 15142872.
External links
- KCNJ5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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