KCNK9
| Potassium channel, subfamily K, member 9 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KCNK9 ; K2p9.1; KT3.2; MGC138268; MGC138270; TASK-3; TASK3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 56758 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE KCNK9 gnf1h00252 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Potassium channel, subfamily K, member 9, also known as KCNK9, is a human gene.[1]
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate.[1]
See also
References
Further reading
- Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078.
- Goldstein SA, Bayliss DA, Kim D; et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
- Kim Y, Bang H, Kim D (2000). "TASK-3, a new member of the tandem pore K(+) channel family". J. Biol. Chem. 275 (13): 9340–7. PMID 10734076.
- Rajan S, Wischmeyer E, Xin Liu G; et al. (2000). "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor". J. Biol. Chem. 275 (22): 16650–7. doi:10.1074/jbc.M000030200. PMID 10747866.
- Chapman CG, Meadows HJ, Godden RJ; et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel". Brain Res. Mol. Brain Res. 82 (1–2): 74–83. PMID 11042359.
- Vega-Saenz de Miera E, Lau DH, Zhadina M; et al. (2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J. Neurophysiol. 86 (1): 130–42. PMID 11431495.
- Talley EM, Bayliss DA (2002). "Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action". J. Biol. Chem. 277 (20): 17733–42. doi:10.1074/jbc.M200502200. PMID 11886861.
- Rajan S, Preisig-Müller R, Wischmeyer E; et al. (2003). "Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3". J. Physiol. (Lond.). 545 (Pt 1): 13–26. PMID 12433946.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Mu D, Chen L, Zhang X; et al. (2003). "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene". Cancer Cell. 3 (3): 297–302. PMID 12676587.
- Pei L, Wiser O, Slavin A; et al. (2003). "Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7803–7. doi:10.1073/pnas.1232448100. PMID 12782791.
- Rusznák Z, Pocsai K, Kovács I; et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476.
- Clarke CE, Veale EL, Green PJ; et al. (2005). "Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc". J. Physiol. (Lond.). 560 (Pt 1): 51–62. doi:10.1113/jphysiol.2004.070292. PMID 15284350.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Kim CJ, Cho YG, Jeong SW; et al. (2005). "Altered expression of KCNK9 in colorectal cancers". APMIS. 112 (9): 588–94. doi:10.1111/j.1600-0463.2004.apm1120905.x. PMID 15601307.
- Pocsai K, Kosztka L, Bakondi G; et al. (2006). "Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture". Cell. Mol. Life Sci. 63 (19–20): 2364–76. doi:10.1007/s00018-006-6166-8. PMID 17013562.
- Zuzarte M, Rinné S, Schlichthörl G; et al. (2007). "A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3". Traffic. 8 (8): 1093–100. doi:10.1111/j.1600-0854.2007.00593.x. PMID 17547699.
External links
- KCNK9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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