KCNQ5
| Potassium voltage-gated channel, KQT-like subfamily, member 5 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KCNQ5 ; Kv7.5 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 28270 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Potassium voltage-gated channel, KQT-like subfamily, member 5, also known as KCNQ5, is a human gene.[1]
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.[1]
See also
References
Further reading
- Gutman GA, Chandy KG, Grissmer S; et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- Lerche C, Scherer CR, Seebohm G; et al. (2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J. Biol. Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.
- Schroeder BC, Hechenberger M, Weinreich F; et al. (2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J. Biol. Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.
- Wickenden AD, Zou A, Wagoner PK, Jegla T (2001). "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells". Br. J. Pharmacol. 132 (2): 381–4. doi:10.1038/sj.bjp.0703861. PMID 11159685.
- Yus-Najera E, Santana-Castro I, Villarroel A (2002). "The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels". J. Biol. Chem. 277 (32): 28545–53. doi:10.1074/jbc.M204130200. PMID 12032157.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ozeki Y, Tomoda T, Kleiderlein J; et al. (2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMID 12506198.
- Yus-Nájera E, Muñoz A, Salvador N; et al. (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. 120 (2): 353–64. PMID 12890507.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Li Y, Langlais P, Gamper N; et al. (2004). "Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase". J. Biol. Chem. 279 (44): 45399–407. doi:10.1074/jbc.M408410200. PMID 15304482.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Jensen HS, Grunnet M, Olesen SP (2007). "Inactivation as a new regulatory mechanism for neuronal Kv7 channels". Biophys. J. 92 (8): 2747–56. doi:10.1529/biophysj.106.101287. PMID 17237198.
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