SCN3A

Sodium channel, voltage-gated, type III, alpha subunit
File:PBB Protein SCN3A image.jpg PDB rendering based on 1byy.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1byy​
Identifiers
Symbols	SCN3A ; KIAA1356; NAC3; Nav1.3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56005
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SCN3A 210432 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sodium channel, voltage-gated, type III, alpha subunit (SCN3A), also known as Nav1.3, is a human gene.

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

See also

• Sodium channel

Further reading

• Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.CS1 maint: Multiple names: authors list (link)
• Malo MS, Srivastava K, Andresen JM; et al. (1994). "Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 2975–9. PMID 8159690.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Lu CM, Brown GB (1998). "Isolation of a human-brain sodium-channel gene encoding two isoforms of the subtype III alpha-subunit". J. Mol. Neurosci. 10 (1): 67–70. PMID 9589372.
• Nagase T, Kikuno R, Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. PMID 10718198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gotthardt M, Trommsdorff M, Nevitt MF; et al. (2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". J. Biol. Chem. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen YH, Dale TJ, Romanos MA; et al. (2001). "Cloning, distribution and functional analysis of the type III sodium channel from human brain". Eur. J. Neurosci. 12 (12): 4281–9. PMID 11122339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kasai N, Fukushima K, Ueki Y; et al. (2001). "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus". Gene. 264 (1): 113–22. PMID 11245985.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Whitaker WR, Faull RL, Dragunow M; et al. (2001). "Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus". Neuroscience. 106 (2): 275–85. PMID 11566500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weiss LA, Escayg A, Kearney JA; et al. (2003). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Mol. Psychiatry. 8 (2): 186–94. doi:10.1038/sj.mp.4001241. PMID 12610651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shah BS, Rush AM, Liu S; et al. (2004). "Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface". J. Neurosci. 24 (33): 7387–99. doi:10.1523/JNEUROSCI.0322-04.2004. PMID 15317864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thimmapaya R, Neelands T, Niforatos W; et al. (2005). "Distribution and functional characterization of human Nav1.3 splice variants". Eur. J. Neurosci. 22 (1): 1–9. doi:10.1111/j.1460-9568.2005.04155.x. PMID 16029190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Platoshyn O, Remillard CV, Fantozzi I; et al. (2006). "Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells". Pflugers Arch. 451 (2): 380–7. doi:10.1007/s00424-005-1478-3. PMID 16052353.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martin MS, Tang B, Ta N, Escayg A (2007). "Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences". Genomics. 90 (2): 225–35. doi:10.1016/j.ygeno.2007.04.006. PMID 17544618.CS1 maint: Multiple names: authors list (link)

External links

• SCN3A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.