SCN8A

Sodium channel, voltage gated, type VIII, alpha subunit
File:PBB Protein SCN8A image.jpg PDB rendering based on 1byy.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1byy​
Identifiers
Symbols	SCN8A ; MED; CerIII; NaCh6; Nav1.6; PN4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7927
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SCN8A 207049 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sodium channel, voltage gated, type VIII, alpha subunit (SCN8A), also known as Nav1.6, is a human gene.

See also

• Sodium channel

Further reading

• Catterall WA, Goldin AL, Waxman SG (2006). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098.CS1 maint: Multiple names: authors list (link)
• Burgess DL, Kohrman DC, Galt J; et al. (1995). "Mutation of a new sodium channel gene, Scn8a, in the mouse mutant 'motor endplate disease'". Nat. Genet. 10 (4): 461–5. doi:10.1038/ng0895-461. PMID 7670495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Plummer NW, McBurney MW, Meisler MH (1997). "Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells". J. Biol. Chem. 272 (38): 24008–15. PMID 9295353.CS1 maint: Multiple names: authors list (link)
• Plummer NW, Galt J, Jones JM; et al. (1999). "Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A". Genomics. 54 (2): 287–96. doi:10.1006/geno.1998.5550. PMID 9828131.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anis Y, Nürnberg B, Visochek L; et al. (1999). "Activation of Go-proteins by membrane depolarization traced by in situ photoaffinity labeling of galphao-proteins with [alpha32P]GTP-azidoanilide". J. Biol. Chem. 274 (11): 7431–40. PMID 10066808.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caldwell JH, Schaller KL, Lasher RS; et al. (2000). "Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5616–20. doi:10.1073/pnas.090034797. PMID 10779552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wittmack EK, Rush AM, Craner MJ; et al. (2005). "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons". J. Neurosci. 24 (30): 6765–75. doi:10.1523/JNEUROSCI.1628-04.2004. PMID 15282281.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raymond CK, Castle J, Garrett-Engele P; et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia". J. Biol. Chem. 279 (44): 46234–41. doi:10.1074/jbc.M406387200. PMID 15302875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drews VL, Lieberman AP, Meisler MH (2005). "Multiple transcripts of sodium channel SCN8A (Na(V)1.6) with alternative 5'- and 3'-untranslated regions and initial characterization of the SCN8A promoter". Genomics. 85 (2): 245–57. doi:10.1016/j.ygeno.2004.09.002. PMID 15676283.CS1 maint: Multiple names: authors list (link)
• Wittmack EK, Rush AM, Hudmon A; et al. (2006). "Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase". J. Neurosci. 25 (28): 6621–30. doi:10.1523/JNEUROSCI.0541-05.2005. PMID 16014723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schiavon E, Sacco T, Cassulini RR; et al. (2006). "Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons". J. Biol. Chem. 281 (29): 20326–37. doi:10.1074/jbc.M600565200. PMID 16702217.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shirahata E, Iwasaki H, Takagi M; et al. (2006). "Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6". J. Neurophysiol. 96 (3): 1347–57. doi:10.1152/jn.01264.2005. PMID 16775201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Black JA, Newcombe J, Trapp BD, Waxman SG (2007). "Sodium channel expression within chronic multiple sclerosis plaques". J. Neuropathol. Exp. Neurol. 66 (9): 828–37. doi:10.1097/nen.0b013e3181462841. PMID 17805013.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.