Decay accelerating factor

CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Identifiers
Symbol	CD55
Alt. symbols	DAF
Entrez	1604
HUGO	2665
OMIM	125240
RefSeq	NM_000574
UniProt	P08174
Other data
Locus	Chr. 1 q32

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

See also

• List of human clusters of differentiation

External links

• Decay-Accelerating+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
• Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH