CXCR7

Chemokine (C-X-C motif) receptor 7
Identifiers
Symbols	CXCR7 ; RDC1; CMKOR1; GPR159
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22419
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chemokine (C-X-C motif) receptor 7, also known as CXCR7, is a human gene.

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Further reading

• Nagata S, Ishihara T, Robberecht P; et al. (1992). "RDC1 may not be VIP receptor". Trends Pharmacol. Sci. 13 (3): 102–3. PMID 1315461.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Libert F, Passage E, Parmentier M; et al. (1992). "Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor". Genomics. 11 (1): 225–7. PMID 1662665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sreedharan SP, Robichon A, Peterson KE, Goetzl EJ (1991). "Cloning and expression of the human vasoactive intestinal peptide receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4986–90. PMID 1675791.CS1 maint: Multiple names: authors list (link)
• Law NM, Rosenzweig SA (1994). "Characterization of the G-protein linked orphan receptor GPRN1/RDC1". Biochem. Biophys. Res. Commun. 201 (1): 458–65. doi:10.1006/bbrc.1994.1723. PMID 8198609.
• Shimizu N, Soda Y, Kanbe K; et al. (2000). "A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses". J. Virol. 74 (2): 619–26. PMID 10623723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broberg K, Zhang M, Strömbeck B; et al. (2003). "Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15". Int. J. Oncol. 21 (2): 321–6. PMID 12118328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balabanian K, Lagane B, Infantino S; et al. (2005). "The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes". J. Biol. Chem. 280 (42): 35760–6. doi:10.1074/jbc.M508234200. PMID 16107333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Infantino S, Moepps B, Thelen M (2006). "Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells". J. Immunol. 176 (4): 2197–207. PMID 16455976.CS1 maint: Multiple names: authors list (link)
• Burns JM, Summers BC, Wang Y; et al. (2006). "A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development". J. Exp. Med. 203 (9): 2201–13. doi:10.1084/jem.20052144. PMID 16940167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Proost P, Mortier A, Loos T; et al. (2007). "Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration". Blood. 110 (1): 37–44. doi:10.1182/blood-2006-10-049072. PMID 17363734.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miao Z, Luker KE; et al. (2007). "CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature". PNAS. 104: 15735–15740.CS1 maint: Explicit use of et al. (link)
• Wang J, Shiozawa Y, Wang J; et al. (2008). "The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer". J Biol Chem. 283. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.