KCNMA1

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Identifiers
Symbols	KCNMA1 ; BKTM; DKFZp686K1437; KCa1.1; MGC71881; MaxiK; SAKCA; SLO; SLO-ALPHA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1693
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KCNMA1 221583 s at tn.png
File:PBB GE KCNMA1 221584 s at tn.png
File:PBB GE KCNMA1 214921 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Potassium large conductance calcium-activated channel, subfamily M, alpha member 1, also known as KCNMA1, is a human gene.

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

See also

• BK channel
• Voltage-gated potassium channel

Further reading

• Magleby KL (2003). "Gating mechanism of BK (Slo1) channels: so near, yet so far". J. Gen. Physiol. 121 (2): 81–96. PMID 12566537.
• Wei AD, Gutman GA, Aldrich R; et al. (2006). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCobb DP, Fowler NL, Featherstone T; et al. (1995). "A human calcium-activated potassium channel gene expressed in vascular smooth muscle". Am. J. Physiol. 269 (3 Pt 2): H767–77. PMID 7573516.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Butler A, Tsunoda S, McCobb DP; et al. (1993). "mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels". Science. 261 (5118): 221–4. PMID 7687074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dworetzky SI, Trojnacki JT, Gribkoff VK (1995). "Cloning and expression of a human large-conductance calcium-activated potassium channel". Brain Res. Mol. Brain Res. 27 (1): 189–93. PMID 7877450.CS1 maint: Multiple names: authors list (link)
• Pallanck L, Ganetzky B (1995). "Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke". Hum. Mol. Genet. 3 (8): 1239–43. PMID 7987297.
• Tseng-Crank J, Foster CD, Krause JD; et al. (1995). "Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain". Neuron. 13 (6): 1315–30. PMID 7993625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knaus HG, Folander K, Garcia-Calvo M; et al. (1994). "Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle". J. Biol. Chem. 269 (25): 17274–8. PMID 8006036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meera P, Wallner M, Jiang Z, Toro L (1996). "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels". FEBS Lett. 382 (1–2): 84–8. PMID 8612769.CS1 maint: Multiple names: authors list (link)
• Wallner M, Meera P, Ottolia M; et al. (1996). "Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium". Recept. Channels. 3 (3): 185–99. PMID 8821792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallner M, Meera P, Toro L (1997). "Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14922–7. PMID 8962157.CS1 maint: Multiple names: authors list (link)
• Meera P, Wallner M, Song M, Toro L (1998). "Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 14066–71. PMID 9391153.CS1 maint: Multiple names: authors list (link)
• Díaz L, Meera P, Amigo J; et al. (1999). "Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel". J. Biol. Chem. 273 (49): 32430–6. PMID 9829973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wallner M, Meera P, Toro L (1999). "Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 4137–42. PMID 10097176.CS1 maint: Multiple names: authors list (link)
• Valverde MA, Rojas P, Amigo J; et al. (1999). "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit". Science. 285 (5435): 1929–31. PMID 10489376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brenner R, Jegla TJ, Wickenden A; et al. (2000). "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4". J. Biol. Chem. 275 (9): 6453–61. PMID 10692449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu QH, Williams DA, McManus C; et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMID 10758170.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quirk JC, Reinhart PH (2001). "Identification of a novel tetramerization domain in large conductance K(ca) channels". Neuron. 32 (1): 13–23. PMID 11604135.
• Soto MA, González C, Lissi E; et al. (2002). "Ca(2+)-activated K+ channel inhibition by reactive oxygen species". Am. J. Physiol., Cell Physiol. 282 (3): C461–71. doi:10.1152/ajpcell.00167.2001. PMID 11832330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang YW, Ding JP, Xia XM, Lingle CJ (2002). "Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels". J. Neurosci. 22 (5): 1550–61. PMID 11880485.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.