TNFRSF25

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Tumor necrosis factor receptor superfamily, member 25
Identifiers
Symbols TNFRSF25 ; TRAMP; TR3; APO-3; DDR3; DR3; LARD; TNFRSF12; WSL-1; WSL-LR
External IDs Template:OMIM5 Template:MGI HomoloGene: 13202
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor necrosis factor receptor superfamily, member 25, also known as TNFRSF25, is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25".

Further reading

  • Metheny-Barlow LJ, Li LY (2006). "Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis". Seminars in ophthalmology. 21 (1): 49–58. doi:10.1080/08820530500511446. PMID 16517446.
  • Chinnaiyan AM, O'Rourke K, Yu GL; et al. (1996). "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95". Science. 274 (5289): 990–2. PMID 8875942.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
  • Kitson J, Raven T, Jiang YP; et al. (1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525.
  • Marsters SA, Sheridan JP, Donahue CJ; et al. (1997). "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B.". Curr. Biol. 6 (12): 1669–76. PMID 8994832.
  • Bodmer JL, Burns K, Schneider P; et al. (1997). "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)". Immunity. 6 (1): 79–88. PMID 9052839.
  • Screaton GR, Xu XN, Olsen AL; et al. (1997). "LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4615–9. PMID 9114039.
  • Warzocha K, Ribeiro P, Charlot C; et al. (1998). "A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas". Biochem. Biophys. Res. Commun. 242 (2): 376–9. doi:10.1006/bbrc.1997.7948. PMID 9446802.
  • Grenet J, Valentine V, Kitson J; et al. (1998). "Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma". Genomics. 49 (3): 385–93. doi:10.1006/geno.1998.5300. PMID 9615223.
  • Jiang Y, Woronicz JD, Liu W, Goeddel DV (1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science. 283 (5401): 543–6. PMID 9915703.
  • Kaptein A, Jansen M, Dilaver G; et al. (2000). "Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)". FEBS Lett. 485 (2–3): 135–41. PMID 11094155.
  • Frankel SK, Van Linden AA, Riches DW (2001). "Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2)". Biochem. Biophys. Res. Commun. 288 (2): 313–20. doi:10.1006/bbrc.2001.5761. PMID 11606045.
  • Migone TS, Zhang J, Luo X; et al. (2002). "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator". Immunity. 16 (3): 479–92. PMID 11911831.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Al-Lamki RS, Wang J, Thiru S; et al. (2003). "Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants". Am. J. Pathol. 163 (2): 401–11. PMID 12875962.
  • Wen L, Zhuang L, Luo X, Wei P (2003). "TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells". J. Biol. Chem. 278 (40): 39251–8. doi:10.1074/jbc.M305833200. PMID 12882979.
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
  • Osawa K, Takami N, Shiozawa K; et al. (2005). "Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis". Genes Immun. 5 (6): 439–43. doi:10.1038/sj.gene.6364097. PMID 15241467.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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