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{{Infobox_gene}}
{{PBB_Controls
'''CD6''' ('''C'''luster of '''D'''ifferentiation 6) is a human [[protein]] encoded by the {{gene|CD6}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD6 CD6 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=923| accessdate = }}</ref><ref name="pmid7760007">{{cite journal | vauthors = Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U | title = Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand | journal = J. Exp. Med. | volume = 181 | issue = 6 | pages = 2213–20 | year = 1995 | pmid = 7760007 | pmc = 2192054 | doi = 10.1084/jem.181.6.2213}}</ref>
| update_page = yes
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD6 molecule
| HGNCid = 1691
| Symbol = CD6
| AltSymbols =; TP120
| OMIM = 186720
| ECnumber = 
| Homologene = 4893
| MGIid = 103566
| Function = {{GNF_GO|id=GO:0005044 |text = scavenger receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 923
    | Hs_Ensembl = ENSG00000013725
    | Hs_RefseqProtein = NP_006716
    | Hs_RefseqmRNA = NM_006725
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 60495728
    | Hs_GenLoc_end = 60544422
    | Hs_Uniprot = P30203
    | Mm_EntrezGene = 12511
    | Mm_Ensembl = ENSMUSG00000024670
    | Mm_RefseqmRNA = NM_001037801
    | Mm_RefseqProtein = NP_001032890
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 10856386
    | Mm_GenLoc_end = 10897098
    | Mm_Uniprot = Q8BGK1
  }}
}}
'''CD6''' ('''C'''luster of '''D'''ifferentiation 6) is a human [[protein]] encoded by the {{gene|CD6}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD6 CD6 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=923| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein found on the outer membrane of [[T-lymphocyte]]s as well as some other immune cells. The encoded protein contains three [[Scavenger receptor cysteine-rich protein domain|scavenger receptor cysteine-rich (SRCR) domain]]s and a binding site for an activated [[ALCAM|leukocyte cell adhesion molecule]]. The gene product is important for continuation of [[T cell activation]].<ref name="entrez"/>
{{PBB_Summary
 
| section_title =  
== Clinical significance ==
| summary_text =  
 
}}
Certain alleles of this gene may be associated with susceptibility to [[multiple sclerosis]].<ref name="pmid19525953">{{cite journal | vauthors = De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR | title = Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci | journal = Nat. Genet. | volume = 41 | issue = 7 | pages = 776–82 | year = 2009 | pmid = 19525953 | pmc = 2757648 | doi = 10.1038/ng.401 | url =  }}</ref><ref name="pmid21849685">{{cite journal | vauthors = Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA | title = The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation | journal = J. Immunol. | volume = 187 | issue = 6 | pages = 3286–91 | year = 2011 | pmid = 21849685 | doi = 10.4049/jimmunol.1100626 }}</ref>


==See also==
==See also==
Line 57: Line 14:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Aruffo A, Melnick MB, Linsley PS, Seed B | title = The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins | journal = J. Exp. Med. | volume = 174 | issue = 4 | pages = 949–52 | year = 1991 | pmid = 1919444 | pmc = 2118957 | doi = 10.1084/jem.174.4.949 }}
| citations =
*{{cite journal | vauthors = Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE | title = Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule | journal = J. Biol. Chem. | volume = 266 | issue = 11 | pages = 7137–43 | year = 1991 | pmid = 2016320 | doi = }}
*{{cite journal | author=Aruffo A, Melnick MB, Linsley PS, Seed B |title=The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. |journal=J. Exp. Med. |volume=174 |issue= 4 |pages= 949-52 |year= 1991 |pmid= 1919444 |doi= }}
*{{cite journal | vauthors = Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T | title = Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11 | journal = Somat. Cell Mol. Genet. | volume = 11 | issue = 3 | pages = 217–22 | year = 1985 | pmid = 3923629 | doi = 10.1007/BF01534678 }}
*{{cite journal | author=Swack JA, Mier JW, Romain PL, ''et al.'' |title=Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. |journal=J. Biol. Chem. |volume=266 |issue= 11 |pages= 7137-43 |year= 1991 |pmid= 2016320 |doi= }}
*{{cite journal | vauthors = Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A | title = The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site | journal = J. Biol. Chem. | volume = 270 | issue = 31 | pages = 18187–90 | year = 1995 | pmid = 7543097 | doi = 10.1074/jbc.270.31.18187 }}
*{{cite journal | author=Tsuge I, Utsumi KR, Ueda R, ''et al.'' |title=Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11. |journal=Somat. Cell Mol. Genet. |volume=11 |issue= 3 |pages= 217-22 |year= 1985 |pmid= 3923629 |doi= }}
*{{cite journal | vauthors = Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR | title = Human CD6 possesses a large, alternatively spliced cytoplasmic domain | journal = Eur. J. Immunol. | volume = 25 | issue = 10 | pages = 2765–9 | year = 1995 | pmid = 7589069 | doi = 10.1002/eji.1830251008 }}
*{{cite journal | author=Whitney GS, Starling GC, Bowen MA, ''et al.'' |title=The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18187-90 |year= 1995 |pmid= 7543097 |doi= }}
*{{cite journal | vauthors = Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A | title = Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors | journal = J. Exp. Med. | volume = 177 | issue = 1 | pages = 219–23 | year = 1993 | pmid = 7678115 | pmc = 2190871 | doi = 10.1084/jem.177.1.219 }}
*{{cite journal | author=Robinson WH, Neuman de Vegvar HE, Prohaska SS, ''et al.'' |title=Human CD6 possesses a large, alternatively spliced cytoplasmic domain. |journal=Eur. J. Immunol. |volume=25 |issue= 10 |pages= 2765-9 |year= 1995 |pmid= 7589069 |doi= }}
*{{cite journal | vauthors = Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A | title = Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms | journal = J. Immunol. | volume = 158 | issue = 3 | pages = 1149–56 | year = 1997 | pmid = 9013954 | doi =  }}
*{{cite journal | author=Wee S, Schieven GL, Kirihara JM, ''et al.'' |title=Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. |journal=J. Exp. Med. |volume=177 |issue= 1 |pages= 219-23 |year= 1993 |pmid= 7678115 |doi= }}
*{{cite journal | vauthors = Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA | title = Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains | journal = Eur. J. Immunol. | volume = 27 | issue = 11 | pages = 2971–80 | year = 1998 | pmid = 9394826 | doi = 10.1002/eji.1830271133 }}
*{{cite journal | author=Bowen MA, Whitney GS, Neubauer M, ''et al.'' |title=Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1149-56 |year= 1997 |pmid= 9013954 |doi=  }}
*{{cite journal | vauthors = Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ | title = CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes | journal = Immunol. Lett. | volume = 58 | issue = 1 | pages = 9–14 | year = 1998 | pmid = 9436462 | doi = 10.1016/S0165-2478(97)02707-7 }}
*{{cite journal | author=Kobarg J, Whitney GS, Palmer D, ''et al.'' |title=Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2971-80 |year= 1998 |pmid= 9394826 |doi= }}
*{{cite journal | vauthors = Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F | title = The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8564–71 | year = 2003 | pmid = 12473675 | doi = 10.1074/jbc.M209591200  }}
*{{cite journal | author=Singer NG, Mitra R, Lialios F, ''et al.'' |title=CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes. |journal=Immunol. Lett. |volume=58 |issue= 1 |pages= 9-14 |year= 1998 |pmid= 9436462 |doi= }}
*{{cite journal | vauthors = Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM | title = Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7607–16 | year = 2003 | pmid = 12493773 | doi = 10.1074/jbc.M210455200 }}
*{{cite journal | author=Gimferrer I, Farnós M, Calvo M, ''et al.'' |title=The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8564-71 |year= 2003 |pmid= 12473675 |doi= 10.1074/jbc.M209591200 }}
*{{cite journal | vauthors = Gimferrer I, Ibáñez A, Farnós M, Sarrias MR, Fenutría R, Roselló S, Zimmermann P, David G, Vives J, Serra-Pagès C, Lozano F | title = The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains | journal = J. Immunol. | volume = 175 | issue = 3 | pages = 1406–14 | year = 2005 | pmid = 16034076 | doi = 10.4049/jimmunol.175.3.1406 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N | title = Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens | journal = J. Immunol. | volume = 177 | issue = 2 | pages = 877–84 | year = 2006 | pmid = 16818742 | doi = 10.4049/jimmunol.177.2.877 }}
*{{cite journal | author=Shin BK, Wang H, Yim AM, ''et al.'' |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607-16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 }}
*{{cite journal | vauthors = Ibáñez A, Sarrias MR, Farnós M, Gimferrer I, Serra-Pagès C, Vives J, Lozano F | title = Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor | journal = J. Immunol. | volume = 177 | issue = 2 | pages = 1152–9 | year = 2006 | pmid = 16818773 | doi = 10.4049/jimmunol.177.2.1152 }}
*{{cite journal | author=Gimferrer I, Ibáñez A, Farnós M, ''et al.'' |title=The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains. |journal=J. Immunol. |volume=175 |issue= 3 |pages= 1406-14 |year= 2005 |pmid= 16034076 |doi= }}
*{{cite journal | vauthors = Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH | title = CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76 | journal = Mol. Cell. Biol. | volume = 26 | issue = 17 | pages = 6727–38 | year = 2006 | pmid = 16914752 | pmc = 1592849 | doi = 10.1128/MCB.00688-06 }}
*{{cite journal | author=Kato Y, Tanaka Y, Hayashi M, ''et al.'' |title=Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 877-84 |year= 2006 |pmid= 16818742 |doi= }}
*{{cite journal | vauthors = Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM | title = Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse | journal = J. Immunol. | volume = 178 | issue = 7 | pages = 4351–61 | year = 2007 | pmid = 17371992 | doi = 10.4049/jimmunol.178.7.4351 }}
*{{cite journal | author=Ibáñez A, Sarrias MR, Farnós M, ''et al.'' |title=Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 1152-9 |year= 2006 |pmid= 16818773 |doi= }}
*{{cite journal | vauthors = Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F | title = CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 104 | issue = 28 | pages = 11724–9 | year = 2007 | pmid = 17601777 | pmc = 1913855 | doi = 10.1073/pnas.0702815104 }}
*{{cite journal | author=Hassan NJ, Simmonds SJ, Clarkson NG, ''et al.'' |title=CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. |journal=Mol. Cell. Biol. |volume=26 |issue= 17 |pages= 6727-38 |year= 2006 |pmid= 16914752 |doi= 10.1128/MCB.00688-06 }}
*{{cite journal | author=Castro MA, Oliveira MI, Nunes RJ, ''et al.'' |title=Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. |journal=J. Immunol. |volume=178 |issue= 7 |pages= 4351-61 |year= 2007 |pmid= 17371992 |doi= }}
*{{cite journal | author=Sarrias MR, Farnós M, Mota R, ''et al.'' |title=CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 28 |pages= 11724-9 |year= 2007 |pmid= 17601777 |doi= 10.1073/pnas.0702815104 }}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* {{MeshName|CD6+protein,+human}}
* {{MeshName|CD6+protein,+human}}
* {{UCSC gene info|CD6}}


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{NLM content}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]


[[es:CD6]]
 
{{WikiDoc Sources}}
{{membrane-protein-stub}}

Latest revision as of 02:17, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[1][2]

Function

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.[1]

Clinical significance

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[3][4]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CD6 CD6 molecule".
  2. ↑ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J. Exp. Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007.
  3. ↑ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet. 41 (7): 776–82. doi:10.1038/ng.401. PMC 2757648. PMID 19525953.
  4. ↑ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation". J. Immunol. 187 (6): 3286–91. doi:10.4049/jimmunol.1100626. PMID 21849685.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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