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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Killer cell immunoglobulin-like receptor 2DL1''' is a [[protein]] that in humans is encoded by the ''KIR2DL1'' [[gene]].<ref name="pmid7749980">{{cite journal | vauthors = Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO | title = Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains | journal = Immunity | volume = 2 | issue = 5 | pages = 439–49 | date = June 1995 | pmid = 7749980 | pmc =  | doi = 10.1016/1074-7613(95)90025-X }}</ref><ref name="pmid7716543">{{cite journal | vauthors = Colonna M, Samaridis J | title = Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells | journal = Science | volume = 268 | issue = 5209 | pages = 405–8 | date = May 1995 | pmid = 7716543 | pmc = | doi = 10.1126/science.7716543 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_KIR2DL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b6u.
| PDB = {{PDB2|1b6u}}, {{PDB2|1efx}}, {{PDB2|1im9}}, {{PDB2|1m4k}}, {{PDB2|1nkr}}, {{PDB2|2dl2}}, {{PDB2|2dli}}
| Name = Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
| HGNCid = 6329
| Symbol = KIR2DL1
| AltSymbols =; 47.11; CD158A; CL-42; KIR-K3; KIR-K64; KIR-K65; KIR-K9; KIR221; NKAT; NKAT1; p58.1; CD158B1; CD158k; CL-43; NKAT6; p58.2; p58; CL-6; CD158B2; CD158b; GL183; KIR-023GB; KIR-K15; KIR-K7c; MGC129943; NKAT2; NKAT2A; NKAT2B; NKR-K7; p58 KIR; CD158H; EB6ActI; EB6ActII; p50.1; KIR2DL3; 183ACTI; CD158J; CL-49; MGC120018; NKAT5; p50.2; NKAT7; 1060P11.7; CD158G; NKAT9
| OMIM = 604936
| ECnumber = 
| Homologene = 74998
| MGIid = 
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0030110 |text = HLA-C specific inhibitory MHC class I receptor activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003823 |text = antigen binding}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3802
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_055033
    | Hs_RefseqmRNA = NM_014218
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1''', also known as '''KIR2DL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Killer-cell immunoglobulin-like receptors]] (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb [[leukocyte receptor complex]] (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several &quot;framework&quot; genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
KIR2DL1 has been shown to [[Protein-protein interaction|interact]] with [[HLA-C]].<ref name=pmid12454284>{{cite journal | vauthors = Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL | title = Disulfide bond-mediated dimerization of HLA-G on the cell surface | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 99 | issue = 25 | pages = 16180–5 | date = December 2002 | pmid = 12454284 | pmc = 138585 | doi = 10.1073/pnas.212643199 }}</ref><ref name=pmid11163076>{{cite journal | vauthors = Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL | title = N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors | journal = Hum. Immunol. | volume = 61 | issue = 12 | pages = 1202–18 | date = December 2000 | pmid = 11163076 | doi = 10.1016/S0198-8859(00)00184-1 }}</ref><ref name=pmid9768753>{{cite journal | vauthors = Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL | title = Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors | journal = Immunity | volume = 9 | issue = 3 | pages = 337–44 | date = September 1998 | pmid = 9768753 | doi = 10.1016/S1074-7613(00)80616-0 }}</ref><ref name=pmid11323700>{{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex | journal = Nat. Immunol. | volume = 2 | issue = 5 | pages = 452–60 | date = May 2001 | pmid = 11323700 | doi = 10.1038/87766 }}</ref>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC | title = Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors | journal = Nature | volume = 389 | issue = 6646 | pages = 96–100 | year = 1997 | pmid = 9288975 | doi = 10.1038/38028 }}
| citations =
* {{cite journal | vauthors = Kim J, Chwae YJ, Kim MY, Choi IH, Park JH, Kim SJ | title = Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors | journal = J. Immunol. | volume = 159 | issue = 8 | pages = 3875–82 | year = 1997 | pmid = 9378975 | doi =  }}
*{{cite journal | author=Colonna M, Samaridis J |title=Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. |journal=Science |volume=268 |issue= 5209 |pages= 405-8 |year= 1995 |pmid= 7716543 |doi= }}
* {{cite journal | vauthors = Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P | title = Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors | journal = Immunity | volume = 7 | issue = 6 | pages = 739–51 | year = 1998 | pmid = 9430220 | doi = 10.1016/S1074-7613(00)80393-3 }}
*{{cite journal | author=Wagtmann N, Biassoni R, Cantoni C, ''et al.'' |title=Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. |journal=Immunity |volume=2 |issue= 5 |pages= 439-49 |year= 1995 |pmid= 7749980 |doi=  }}
* {{cite journal | vauthors = Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P | title = Human diversity in killer cell inhibitory receptor genes | journal = Immunity | volume = 7 | issue = 6 | pages = 753–63 | year = 1998 | pmid = 9430221 | doi = 10.1016/S1074-7613(00)80394-5 }}
*{{cite journal | author=Fan QR, Mosyak L, Winter CC, ''et al.'' |title=Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. |journal=Nature |volume=389 |issue= 6646 |pages= 96-100 |year= 1997 |pmid= 9288975 |doi= 10.1038/38028 }}
* {{cite journal | vauthors = Rajagopalan S, Long EO | title = Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells | journal = J. Immunol. | volume = 161 | issue = 3 | pages = 1299–305 | year = 1998 | pmid = 9686591 | doi =  }}
*{{cite journal | author=Kim J, Chwae YJ, Kim MY, ''et al.'' |title=Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 3875-82 |year= 1997 |pmid= 9378975 |doi= }}
* {{cite journal | vauthors = Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL | title = Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors | journal = Immunity | volume = 9 | issue = 3 | pages = 337–44 | year = 1998 | pmid = 9768753 | doi = 10.1016/S1074-7613(00)80616-0 }}
*{{cite journal | author=Valiante NM, Uhrberg M, Shilling HG, ''et al.'' |title=Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. |journal=Immunity |volume=7 |issue= 6 |pages= 739-51 |year= 1998 |pmid= 9430220 |doi=  }}
* {{cite journal | vauthors = Shilling HG, Lienert-Weidenbach K, Valiante NM, Uhrberg M, Parham P | title = Evidence for recombination as a mechanism for KIR diversification | journal = Immunogenetics | volume = 48 | issue = 6 | pages = 413–6 | year = 1998 | pmid = 9799338 | doi = 10.1007/s002510050453 }}
*{{cite journal | author=Uhrberg M, Valiante NM, Shum BP, ''et al.'' |title=Human diversity in killer cell inhibitory receptor genes. |journal=Immunity |volume=7 |issue= 6 |pages= 753-63 |year= 1998 |pmid= 9430221 |doi= }}
* {{cite journal | vauthors = Chwae YJ, Cho SE, Kim SJ, Kim J | title = Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual | journal = Immunol. Lett. | volume = 68 | issue = 2–3 | pages = 267–74 | year = 1999 | pmid = 10424431 | doi = 10.1016/S0165-2478(99)00062-0 }}
*{{cite journal | author=Rajagopalan S, Long EO |title=Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. |journal=J. Immunol. |volume=161 |issue= 3 |pages= 1299-305 |year= 1998 |pmid= 9686591 |doi= }}
* {{cite journal | vauthors = Fan QR, Wiley DC | title = Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor | journal = J. Exp. Med. | volume = 190 | issue = 1 | pages = 113–23 | year = 1999 | pmid = 10429675 | pmc = 2195553 | doi = 10.1084/jem.190.1.113 }}
*{{cite journal | author=Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL |title=Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. |journal=Immunity |volume=9 |issue= 3 |pages= 337-44 |year= 1998 |pmid= 9768753 |doi= }}
* {{cite journal | vauthors = Richardson J, Reyburn HT, Luque I, Valés-Gómez M, Strominger JL | title = Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site | journal = Eur. J. Immunol. | volume = 30 | issue = 5 | pages = 1480–5 | year = 2000 | pmid = 10820396 | doi = 10.1002/(SICI)1521-4141(200005)30:5<1480::AID-IMMU1480>3.0.CO;2-7 }}
*{{cite journal | author=Shilling HG, Lienert-Weidenbach K, Valiante NM, ''et al.'' |title=Evidence for recombination as a mechanism for KIR diversification. |journal=Immunogenetics |volume=48 |issue= 6 |pages= 413-6 |year= 1998 |pmid= 9799338 |doi= }}
* {{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer | journal = Eur. J. Immunol. | volume = 30 | issue = 9 | pages = 2692–7 | year = 2000 | pmid = 11009104 | doi = 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 }}
*{{cite journal | author=Chwae YJ, Cho SE, Kim SJ, Kim J |title=Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual. |journal=Immunol. Lett. |volume=68 |issue= 2-3 |pages= 267-74 |year= 1999 |pmid= 10424431 |doi= }}
* {{cite journal | vauthors = Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL | title = N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors | journal = Hum. Immunol. | volume = 61 | issue = 12 | pages = 1202–18 | year = 2001 | pmid = 11163076 | doi = 10.1016/S0198-8859(00)00184-1 }}
*{{cite journal  | author=Fan QR, Wiley DC |title=Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor. |journal=J. Exp. Med. |volume=190 |issue= 1 |pages= 113-23 |year= 1999 |pmid= 10429675 |doi= }}
* {{cite journal | vauthors = Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P | title = Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors | journal = Tissue Antigens | volume = 57 | issue = 1 | pages = 22–31 | year = 2001 | pmid = 11169255 | doi = 10.1034/j.1399-0039.2001.057001022.x }}
*{{cite journal  | author=Richardson J, Reyburn HT, Luque I, ''et al.'' |title=Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site. |journal=Eur. J. Immunol. |volume=30 |issue= 5 |pages= 1480-5 |year= 2000 |pmid= 10820396 |doi=  }}
* {{cite journal | vauthors = Fan QR, Long EO, Wiley DC | title = Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex | journal = Nat. Immunol. | volume = 2 | issue = 5 | pages = 452–60 | year = 2001 | pmid = 11323700 | doi = 10.1038/87766 }}
*{{cite journal | author=Fan QR, Long EO, Wiley DC |title=A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer. |journal=Eur. J. Immunol. |volume=30 |issue= 9 |pages= 2692-7 |year= 2000 |pmid= 11009104 |doi= 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 }}
* {{cite journal | vauthors = Guerra N, Michel F, Gati A, Gaudin C, Mishal Z, Escudier B, Acuto O, Chouaib S, Caignard A | title = Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction | journal = Blood | volume = 100 | issue = 8 | pages = 2874–81 | year = 2002 | pmid = 12351398 | doi = 10.1182/blood-2002-02-0643 }}
*{{cite journal | author=Baba E, Erskine R, Boyson JE, ''et al.'' |title=N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors. |journal=Hum. Immunol. |volume=61 |issue= 12 |pages= 1202-18 |year= 2001 |pmid= 11163076 |doi= }}
* {{cite journal | vauthors = Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A | title = Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction | journal = Blood | volume = 100 | issue = 12 | pages = 4098–107 | year = 2003 | pmid = 12393468 | doi = 10.1182/blood-2002-04-1284 }}
*{{cite journal | author=Rajalingam R, Gardiner CM, Canavez F, ''et al.'' |title=Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 22-31 |year= 2001 |pmid= 11169255 |doi= }}
* {{cite journal | vauthors = Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL | title = Disulfide bond-mediated dimerization of HLA-G on the cell surface | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 25 | pages = 16180–5 | year = 2003 | pmid = 12454284 | pmc = 138585 | doi = 10.1073/pnas.212643199 }}
*{{cite journal | author=Fan QR, Long EO, Wiley DC |title=Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. |journal=Nat. Immunol. |volume=2 |issue= 5 |pages= 452-60 |year= 2001 |pmid= 11323700 |doi= 10.1038/87766 }}
*{{cite journal | author=Guerra N, Michel F, Gati A, ''et al.'' |title=Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction. |journal=Blood |volume=100 |issue= 8 |pages= 2874-81 |year= 2002 |pmid= 12351398 |doi= 10.1182/blood-2002-02-0643 }}
*{{cite journal | author=Spaggiari GM, Contini P, Dondero A, ''et al.'' |title=Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. |journal=Blood |volume=100 |issue= 12 |pages= 4098-107 |year= 2003 |pmid= 12393468 |doi= 10.1182/blood-2002-04-1284 }}
*{{cite journal  | author=Boyson JE, Erskine R, Whitman MC, ''et al.'' |title=Disulfide bond-mediated dimerization of HLA-G on the cell surface. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16180-5 |year= 2003 |pmid= 12454284 |doi= 10.1073/pnas.212643199 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{PDB Gallery|geneid=3802}}
{{Clusters of differentiation}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
 
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Immunoglobulin superfamily]]
 
 
{{membrane-protein-stub}}
{{immunology-stub}}

Latest revision as of 06:29, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Killer cell immunoglobulin-like receptor 2DL1 is a protein that in humans is encoded by the KIR2DL1 gene.[1][2][3]

Function

Killer-cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[3]

Interactions

KIR2DL1 has been shown to interact with HLA-C.[4][5][6][7]

See also

References

  1. ↑ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (June 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity. 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980.
  2. ↑ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science. 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543.
  3. ↑ 3.0 3.1 "Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1".
  4. ↑ Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL (December 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16180–5. doi:10.1073/pnas.212643199. PMC 138585. PMID 12454284.
  5. ↑ Baba E, Erskine R, Boyson JE, Cohen GB, Davis DM, Malik P, Mandelboim O, Reyburn HT, Strominger JL (December 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. PMID 11163076.
  6. ↑ Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity. 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. PMID 9768753.
  7. ↑ Fan QR, Long EO, Wiley DC (May 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. 2 (5): 452–60. doi:10.1038/87766. PMID 11323700.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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