CD49a: Difference between revisions
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'''CD49a''' is an [[integrin]] alpha subunit. It makes up half of the α1β1 integrin duplex. | '''CD49a''' is an [[integrin]] alpha subunit. It makes up half of the α1β1 integrin duplex. | ||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.<ref name="entrez">{{cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = | | summary_text = This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for [[collagen]] and [[laminin]]. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.<ref name="entrez">{{cite web | title = Entrez Gene: ITGA1 integrin, alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3672| accessdate = }}</ref> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Virtanen I, Korhonen M, Kariniemi AL |title=Integrins in human cells and tumors. |journal=Cell Differ. Dev. |volume=32 |issue= 3 |pages= 215–27 |year= 1991 |pmid= 2099238 |doi=10.1016/0922-3371(90)90034-T |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Plenz GA, Deng MC, Robenek H, Völker W |title=Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis. |journal=Atherosclerosis |volume=166 |issue= 1 |pages= 1–11 |year= 2003 |pmid= 12482545 |doi=10.1016/S0021-9150(01)00766-3 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Clover J, Dodds RA, Gowen M |title=Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. |journal=J. Cell Sci. |volume=103 |issue= 1|pages= 267–71 |year= 1992 |pmid= 1429908 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Bodary SC, McLean JW |title=The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5938–41 |year= 1990 |pmid= 1690718 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Sonnenberg A, Linders CJ, Modderman PW |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145–55 |year= 1990 |pmid= 1693624 |doi=10.1083/jcb.110.6.2145 | pmc=2116116 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Belkin VM, Belkin AM, Dol'nikova AE |title=[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles] |journal=Biokhimiia |volume=56 |issue= 12 |pages= 2198–206 |year= 1992 |pmid= 1807406 |doi= |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Bank I, Roth D, Book M |title=Expression and functions of very late antigen 1 in inflammatory joint diseases. |journal=J. Clin. Immunol. |volume=11 |issue= 1 |pages= 29–38 |year= 1991 |pmid= 1827128 |doi=10.1007/BF00918792 |display-authors=etal}} | ||
*{{cite journal | author=Tabibzadeh S |title=Evidence of T-cell activation and potential cytokine action in human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=71 |issue= 3 |pages= | *{{cite journal | author=Tabibzadeh S |title=Evidence of T-cell activation and potential cytokine action in human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=71 |issue= 3 |pages= 645–9 |year= 1990 |pmid= 2144294 |doi=10.1210/jcem-71-3-645 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Tawil NJ, Houde M, Blacher R |title=Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. |journal=Biochemistry |volume=29 |issue= 27 |pages= 6540–4 |year= 1990 |pmid= 2169872 |doi=10.1021/bi00479a028 | pmc=2710132 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Belkin VM, Belkin AM, Koteliansky VE |title=Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development. |journal=J. Cell Biol. |volume=111 |issue= 5 Pt 1 |pages= 2159–70 |year= 1990 |pmid= 2229189 |doi=10.1083/jcb.111.5.2159 | pmc=2116325 }} | ||
*{{cite journal | | *{{cite journal | vauthors=MacDonald TT, Horton MA, Choy MY, Richman PI |title=Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. |journal=J. Clin. Pathol. |volume=43 |issue= 4 |pages= 313–5 |year= 1990 |pmid= 2341567 |doi=10.1136/jcp.43.4.313 | pmc=502365 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Takada Y, Strominger JL, Hemler ME |title=The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 10 |pages= 3239–43 |year= 1987 |pmid= 3033641 |doi=10.1073/pnas.84.10.3239 | pmc=304844 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Hemler ME, Huang C, Schwarz L |title=The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3300–9 |year= 1987 |pmid= 3546305 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kono Y, Yang S, Letarte M, Roberts EA |title=Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system. |journal=Exp. Cell Res. |volume=221 |issue= 2 |pages= 478–85 |year= 1996 |pmid= 7493648 |doi= 10.1006/excr.1995.1399 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Eglinton BA, Roberton DM, Cummins AG |title=Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk. |journal=Immunol. Cell Biol. |volume=72 |issue= 4 |pages= 306–13 |year= 1995 |pmid= 7806264 |doi=10.1038/icb.1994.46 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Salter DM, Godolphin JL, Gourlay MS |title=Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees. |journal=J. Histochem. Cytochem. |volume=43 |issue= 4 |pages= 447–57 |year= 1995 |pmid= 7897185 |doi= 10.1177/43.4.7897185}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pfaff M, Aumailley M, Specks U |title=Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI. |journal=Exp. Cell Res. |volume=206 |issue= 1 |pages= 167–76 |year= 1993 |pmid= 8387021 |doi= 10.1006/excr.1993.1134 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Briesewitz R, Epstein MR, Marcantonio EE |title=Expression of native and truncated forms of the human integrin alpha 1 subunit. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2989–96 |year= 1993 |pmid= 8428973 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Langholz O, Röckel D, Mauch C |title=Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 2 |pages= 1903–15 |year= 1996 |pmid= 8557756 |doi=10.1083/jcb.131.6.1903 | pmc=2120685 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=3672}} | |||
==External links== | ==External links== | ||
* {{MeshName|CD49a+antigen}} | * {{MeshName|CD49a+antigen}} | ||
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3672 ITGA1] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] | |||
* {{UCSC gene info|ITGA1}} | |||
{{Clusters of differentiation}} | |||
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{{Integrins}} | |||
[[Category:Integrins]] | |||
{{immunology-stub}} | {{immunology-stub}} | ||
Latest revision as of 19:29, 8 November 2017
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Species | Human | Mouse | |||||
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[1]
References
Further reading
- Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors". Cell Differ. Dev. 32 (3): 215–27. doi:10.1016/0922-3371(90)90034-T. PMID 2099238.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". J. Cell Sci. 103 (1): 267–71. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". J. Biol. Chem. 265 (11): 5938–41. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". J. Cell Biol. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". J. Clin. Immunol. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". J. Clin. Endocrinol. Metab. 71 (3): 645–9. doi:10.1210/jcem-71-3-645. PMID 2144294.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–4. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". J. Cell Biol. 111 (5 Pt 1): 2159–70. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". J. Clin. Pathol. 43 (4): 313–5. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". J. Biol. Chem. 262 (7): 3300–9. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Exp. Cell Res. 221 (2): 478–85. doi:10.1006/excr.1995.1399. PMID 7493648.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunol. Cell Biol. 72 (4): 306–13. doi:10.1038/icb.1994.46. PMID 7806264.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". J. Histochem. Cytochem. 43 (4): 447–57. doi:10.1177/43.4.7897185. PMID 7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp. Cell Res. 206 (1): 167–76. doi:10.1006/excr.1993.1134. PMID 8387021.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". J. Biol. Chem. 268 (4): 2989–96. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". J. Cell Biol. 131 (6 Pt 2): 1903–15. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.
External links
- CD49a+antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ITGA1 Info with links in the Cell Migration Gateway
- Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
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