CD72: Difference between revisions
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'''CD72''' ('''C'''luster of '''D'''ifferentiation '''72'''), also known in [[murine]] biology as '''Lyb-2''', is a protein active in the [[immune system]] of animals. It consists of two identical halves, each of about 39-43 [[Dalton (unit)|kD]], and is a C-type [[lectin]]. Its primarily locus of expression is [[B-cells]], where it appears to mediate aspects of B-cell - [[T-cell]] interaction. It is a ligand for [[CD5 (protein)|CD5]].<ref>Abbas, A | '''CD72''' ('''C'''luster of '''D'''ifferentiation '''72'''), also known in [[murine]] biology as '''Lyb-2''', is a protein active in the [[immune system]] of animals. It consists of two identical halves, each of about 39-43 [[Dalton (unit)|kD]], and is a C-type [[lectin]]. Its primarily locus of expression is [[B-cells]] (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - [[T-cell]] interaction. It is a ligand for [[CD5 (protein)|CD5]].<ref>{{cite book | vauthors = Abbas AK, Licktman A |title=Cellular and Molecular Immunology |publisher=Saunders | year = 2003 |isbn=978-0-7216-0008-6 |edition=5th | page = 512 }}</ref> | ||
==See also== | CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.<ref>{{cite journal | vauthors = Parnes JR, Pan C | title = CD72, a negative regulator of B-cell responsiveness | journal = Immunological Reviews | volume = 176 | issue = 1 | pages = 75–85 | date = August 2000 | pmid = 11043769 | doi = 10.1034/j.1600-065x.2000.00608.x }}</ref> | ||
== See also == | |||
* [[Cluster of differentiation]] | * [[Cluster of differentiation]] | ||
==References== | == References == | ||
{{reflist}} | |||
==External links== | == External links == | ||
*[http://med.stanford.edu/profiles/Jane_Parnes/ Dr. Jane Parnes lab] at [[Stanford University]] | *[http://med.stanford.edu/profiles/Jane_Parnes/ Dr. Jane Parnes lab] at [[Stanford University]] | ||
Latest revision as of 07:29, 10 January 2019
| CD72 molecule | |
|---|---|
| Identifiers | |
| Symbol | CD72 |
| Entrez | 971 |
| HUGO | 1696 |
| OMIM | 107272 |
| RefSeq | NM_001782 |
| UniProt | P21854 |
| Other data | |
| Locus | Chr. 9 p |
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.[1]
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.[2]
See also
References
- ↑ Abbas AK, Licktman A (2003). Cellular and Molecular Immunology (5th ed.). Saunders. p. 512. ISBN 978-0-7216-0008-6.
- ↑ Parnes JR, Pan C (August 2000). "CD72, a negative regulator of B-cell responsiveness". Immunological Reviews. 176 (1): 75–85. doi:10.1034/j.1600-065x.2000.00608.x. PMID 11043769.
External links
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