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'''Leukocyte immunoglobulin-like receptor subfamily B member 4''' is a [[protein]] that in humans is encoded by the ''LILRB4'' [[gene]].<ref name="pmid9151699">{{cite journal |vauthors=Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M | title = A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing | journal = J Exp Med | volume = 185 | issue = 10 | pages = 1743–51 |date=Jun 1997 | pmid = 9151699 | pmc = 2196312 | doi =10.1084/jem.185.10.1743  }}</ref><ref name="pmid9079806">{{cite journal |vauthors=Samaridis J, Colonna M | title = Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways | journal = Eur J Immunol | volume = 27 | issue = 3 | pages = 660–5 |date=Apr 1997 | pmid = 9079806 | pmc =  | doi =10.1002/eji.1830270313 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
| HGNCid = 6608
| Symbol = LILRB4
| AltSymbols =; LILRB5; CD85K; HM18; ILT3; LIR-5; LIR5
| OMIM = 604821
| ECnumber = 
| Homologene = 88468
| MGIid = 
| GeneAtlas_image1 = PBB_GE_LILRB4_210152_at_tn.png
| Function = {{GNF_GO|id=GO:0003823 |text = antigen binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11006
    | Hs_Ensembl = ENSG00000186818
    | Hs_RefseqProtein = NP_001074907
    | Hs_RefseqmRNA = NM_001081438
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 59866264
    | Hs_GenLoc_end = 59873619
    | Hs_Uniprot = Q8NHJ6
    | Mm_EntrezGene =   
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4''', also known as '''LILRB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11006| accessdate = }}</ref>
| summary_text = This gene is a member of the [[leukocyte immunoglobulin-like receptor]] (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}
==Interactions==
LILRB4 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]]<ref name="pmid9973385">{{cite journal | vauthors = Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM | title = Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B | journal = Journal of Immunology | volume = 162 | issue = 3 | pages = 1318–23 | year = 1999 | pmid = 9973385 | doi =  }}</ref> and [[INPP5D]] (SHIP-1).<ref name="pmid28931525">{{cite journal | vauthors = Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, Raspadori D, Campoccia G, Sanseviero F, Bocchia M, Baldari CT, Kabanova A | title = Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia | journal = Blood | volume = 130 | issue = 18 | pages = 2006–2017 | year = 2017 | pmid = 28931525 | doi = 10.1182/blood-2017-03-775858 }}</ref>


==See also==
==See also==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]
* [[Immunoglobulin superfamily]]


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Suciu-Foca N, Cortesini R |title=Central role of ILT3 in the T suppressor cell cascade. |journal=Cell. Immunol. |volume=248 |issue= 1 |pages= 59-67 |year= 2007 |pmid= 17923119 |doi= 10.1016/j.cellimm.2007.01.013 }}
*{{cite journal  |vauthors=Suciu-Foca N, Cortesini R |title=Central role of ILT3 in the T suppressor cell cascade |journal=Cell. Immunol. |volume=248 |issue= 1 |pages= 59–67 |year= 2007 |pmid= 17923119 |doi= 10.1016/j.cellimm.2007.01.013 }}
*{{cite journal  | author=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660-5 |year= 1997 |pmid= 9079806 |doi=  }}
*{{cite journal  |vauthors=Arm JP, Nwankwo C, Austen KF |title=Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor |journal=J. Immunol. |volume=159 |issue= 5 |pages= 2342–9 |year= 1997 |pmid= 9278324 |doi=  }}
*{{cite journal | author=Cella M, Döhring C, Samaridis J, ''et al.'' |title=A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. |journal=J. Exp. Med. |volume=185 |issue= 10 |pages= 1743-51 |year= 1997 |pmid= 9151699 |doi=  }}
*{{cite journal   |vauthors=Kuroiwa A, Yamashita Y, Inui M, etal |title=Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 1070–4 |year= 1998 |pmid= 9422771 |doi=10.1074/jbc.273.2.1070 }}
*{{cite journal | author=Arm JP, Nwankwo C, Austen KF |title=Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. |journal=J. Immunol. |volume=159 |issue= 5 |pages= 2342-9 |year= 1997 |pmid= 9278324 |doi=  }}
*{{cite journal   |vauthors=Borges L, Hsu ML, Fanger N, etal |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192–6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal | author=Kuroiwa A, Yamashita Y, Inui M, ''et al.'' |title=Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 1070-4 |year= 1998 |pmid= 9422771 |doi= }}
*{{cite journal   |vauthors=Torkar M, Norgate Z, Colonna M, etal |title=Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex |journal=Eur. J. Immunol. |volume=28 |issue= 12 |pages= 3959–67 |year= 1999 |pmid= 9862332 |doi=10.1002/(SICI)1521-4141(199812)28:12<3959::AID-IMMU3959>3.0.CO;2-2  }}
*{{cite journal | author=Borges L, Hsu ML, Fanger N, ''et al.'' |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192-6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal   |vauthors=Wang LL, Blasioli J, Plas DR, etal |title=Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B |journal=J. Immunol. |volume=162 |issue= 3 |pages= 1318–23 |year= 1999 |pmid= 9973385 |doi=  }}
*{{cite journal | author=Torkar M, Norgate Z, Colonna M, ''et al.'' |title=Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex. |journal=Eur. J. Immunol. |volume=28 |issue= 12 |pages= 3959-67 |year= 1999 |pmid= 9862332 |doi= }}
*{{cite journal   |vauthors=Wilson MJ, Torkar M, Haude A, etal |title=Plasticity in the organization and sequences of human KIR/ILT gene families |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4778–83 |year= 2000 |pmid= 10781084 |doi= 10.1073/pnas.080588597  | pmc=18309 }}
*{{cite journal | author=Wang LL, Blasioli J, Plas DR, ''et al.'' |title=Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. |journal=J. Immunol. |volume=162 |issue= 3 |pages= 1318-23 |year= 1999 |pmid= 9973385 |doi= }}
*{{cite journal   |vauthors=Heinzmann A, Blattmann S, Forster J, etal |title=Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy |journal=Eur. J. Immunogenet. |volume=27 |issue= 3 |pages= 121–7 |year= 2000 |pmid= 10940079 |doi=10.1046/j.1365-2370.2000.00214.x  }}
*{{cite journal | author=Wilson MJ, Torkar M, Haude A, ''et al.'' |title=Plasticity in the organization and sequences of human KIR/ILT gene families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4778-83 |year= 2000 |pmid= 10781084 |doi= 10.1073/pnas.080588597 }}
*{{cite journal   |vauthors=Liu WR, Kim J, Nwankwo C, etal |title=Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4 |journal=Immunogenetics |volume=51 |issue= 8–9 |pages= 659–69 |year= 2000 |pmid= 10941837 |doi=10.1007/s002510000183  }}
*{{cite journal | author=Heinzmann A, Blattmann S, Forster J, ''et al.'' |title=Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. |journal=Eur. J. Immunogenet. |volume=27 |issue= 3 |pages= 121-7 |year= 2000 |pmid= 10940079 |doi=  }}
*{{cite journal   |vauthors=Young NT, Canavez F, Uhrberg M, etal |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=10.1007/s002510100332 }}
*{{cite journal | author=Liu WR, Kim J, Nwankwo C, ''et al.'' |title=Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 659-69 |year= 2000 |pmid= 10941837 |doi= }}
*{{cite journal   |vauthors=Chang CC, Ciubotariu R, Manavalan JS, etal |title=Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 |journal=Nat. Immunol. |volume=3 |issue= 3 |pages= 237–43 |year= 2002 |pmid= 11875462 |doi= 10.1038/ni760 }}
*{{cite journal | author=Young NT, Canavez F, Uhrberg M, ''et al.'' |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270-8 |year= 2001 |pmid= 11491530 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Chang CC, Ciubotariu R, Manavalan JS, ''et al.'' |title=Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. |journal=Nat. Immunol. |volume=3 |issue= 3 |pages= 237-43 |year= 2002 |pmid= 11875462 |doi= 10.1038/ni760 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED |title=HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells |journal=FASEB J. |volume=19 |issue= 6 |pages= 662–4 |year= 2005 |pmid= 15670976 |doi= 10.1096/fj.04-1617fje }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Garner LI, Salim M, Mohammed F, Willcox BE |title=Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies |journal=Protein Expr. Purif. |volume=47 |issue= 2 |pages= 490–7 |year= 2006 |pmid= 16406677 |doi= 10.1016/j.pep.2005.11.020 }}
*{{cite journal | author=LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED |title=HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells. |journal=FASEB J. |volume=19 |issue= 6 |pages= 662-4 |year= 2005 |pmid= 15670976 |doi= 10.1096/fj.04-1617fje }}
*{{cite journal   |vauthors=Kim-Schulze S, Seki T, Vlad G, etal |title=Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells |journal=Am. J. Transplant. |volume=6 |issue= 1 |pages= 76–82 |year= 2006 |pmid= 16433759 |doi= 10.1111/j.1600-6143.2005.01162.x }}
*{{cite journal | author=Garner LI, Salim M, Mohammed F, Willcox BE |title=Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies. |journal=Protein Expr. Purif. |volume=47 |issue= 2 |pages= 490-7 |year= 2006 |pmid= 16406677 |doi= 10.1016/j.pep.2005.11.020 }}
*{{cite journal   |vauthors=Kim-Schulze S, Scotto L, Vlad G, etal |title=Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells |journal=J. Immunol. |volume=176 |issue= 5 |pages= 2790–8 |year= 2006 |pmid= 16493035 |doi= 10.4049/jimmunol.176.5.2790}}
*{{cite journal  | author=Kim-Schulze S, Seki T, Vlad G, ''et al.'' |title=Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells. |journal=Am. J. Transplant. |volume=6 |issue= 1 |pages= 76-82 |year= 2006 |pmid= 16433759 |doi= 10.1111/j.1600-6143.2005.01162.x }}
*{{cite journal   |vauthors=Vlad G, Liu Z, Zhang QY, etal |title=Immunosuppressive activity of recombinant ILT3 |journal=Int. Immunopharmacol. |volume=6 |issue= 13–14 |pages= 1889–94 |year= 2007 |pmid= 17161342 |doi= 10.1016/j.intimp.2006.07.017 }}
*{{cite journal  | author=Kim-Schulze S, Scotto L, Vlad G, ''et al.'' |title=Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells. |journal=J. Immunol. |volume=176 |issue= 5 |pages= 2790-8 |year= 2006 |pmid= 16493035 |doi=  }}
*{{cite journal | author=Vlad G, Liu Z, Zhang QY, ''et al.'' |title=Immunosuppressive activity of recombinant ILT3. |journal=Int. Immunopharmacol. |volume=6 |issue= 13-14 |pages= 1889-94 |year= 2007 |pmid= 17161342 |doi= 10.1016/j.intimp.2006.07.017 }}
}}
}}
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{{refend}}
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* {{MeshName|LILRB4+protein,+human}}
* {{MeshName|LILRB4+protein,+human}}


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{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
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[[Category:Immunoglobulin superfamily]]
 
 
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Latest revision as of 04:07, 25 November 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 4 is a protein that in humans is encoded by the LILRB4 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

LILRB4 has been shown to interact with PTPN6[4] and INPP5D (SHIP-1).[5]

See also

References

  1. ↑ Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing". J Exp Med. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
  2. ↑ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
  3. ↑ 3.0 3.1 "Entrez Gene: LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4".
  4. ↑ Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM (1999). "Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B". Journal of Immunology. 162 (3): 1318–23. PMID 9973385.
  5. ↑ Zurli V, Wimmer G, Cattaneo F, Candi V, Cencini E, Gozzetti A, Raspadori D, Campoccia G, Sanseviero F, Bocchia M, Baldari CT, Kabanova A (2017). "Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia". Blood. 130 (18): 2006–2017. doi:10.1182/blood-2017-03-775858. PMID 28931525.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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