NT5E: Difference between revisions

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Latest revision as of 13:17, 5 September 2017

5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene.^[1] CD73 commonly serves to convert AMP to adenosine.

Function

Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.^[2] Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.^[3]^[4]^[5]

References

↑ Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". European Journal of Biochemistry. 191 (3): 563–9. doi:10.1111/j.1432-1033.1990.tb19158.x. PMID 2129526.
↑ "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)".
↑ St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M (February 2011). "NT5E mutations and arterial calcifications". The New England Journal of Medicine. 364 (5): 432–42. doi:10.1056/NEJMoa0912923. PMC 3049958. PMID 21288095.
↑ Sharp J (March 1954). "Heredo-familial vascular and articular calcification". Annals of the Rheumatic Diseases. 13 (1): 15–27. doi:10.1136/ard.13.1.15. PMC 1030367. PMID 13149051.
↑ Online Mendelian Inheritance in Man (OMIM) 211800

Resta R, Thompson LF (February 1997). "T cell signalling through CD73". Cellular Signalling. 9 (2): 131–9. doi:10.1016/S0898-6568(96)00132-5. PMID 9113412.
Kirchhoff C, Hale G (March 1996). "Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation". Molecular Human Reproduction. 2 (3): 177–84. doi:10.1093/molehr/2.3.177. PMID 9238677.
Resta R, Yamashita Y, Thompson LF (February 1998). "Ecto-enzyme and signaling functions of lymphocyte CD73". Immunological Reviews. 161: 95–109. doi:10.1111/j.1600-065X.1998.tb01574.x. PMID 9553767.
Rosi F, Carlucci F, Marinello E, Tabucchi A (March 2002). "Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia". Biomedicine & Pharmacotherapy. 56 (2): 100–4. doi:10.1016/S0753-3322(01)00072-5. PMID 12000134.
Babiychuk EB, Draeger A (June 2006). "Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement?". Biochemical Society Transactions. 34 (Pt 3): 374–6. doi:10.1042/BST0340374. PMID 16709165.
Stefanovic V, Mandel P, Rosenberg A (July 1976). "Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells". The Journal of Biological Chemistry. 251 (13): 3900–5. PMID 819433.
Thomson LF, Ruedi JM, Glass A, Moldenhauer G, Moller P, Low MG, Klemens MR, Massaia M, Lucas AH (January 1990). "Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73)". Tissue Antigens. 35 (1): 9–19. doi:10.1111/j.1399-0039.1990.tb01750.x. PMID 2137649.
Klemens MR, Sherman WR, Holmberg NJ, Ruedi JM, Low MG, Thompson LF (November 1990). "Characterization of soluble vs membrane-bound human placental 5'-nucleotidase". Biochemical and Biophysical Research Communications. 172 (3): 1371–7. doi:10.1016/0006-291X(90)91601-N. PMID 2173922.
Boyle JM, Hey Y, Guerts van Kessel A, Fox M (December 1988). "Assignment of ecto-5'-nucleotidase to human chromosome 6". Human Genetics. 81 (1): 88–92. doi:10.1007/BF00283737. PMID 2848759.
Vlahović P, Stefanović V (1995). "Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells". Archives Internationales De Physiologie, De Biochimie Et De Biophysique. 102 (3): 171–3. PMID 8000038.
Hansen KR, Resta R, Webb CF, Thompson LF (December 1995). "Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene". Gene. 167 (1–2): 307–12. doi:10.1016/0378-1119(95)00574-9. PMID 8566797.
Airas L, Jalkanen S (September 1996). "CD73 mediates adhesion of B cells to follicular dendritic cells". Blood. 88 (5): 1755–64. PMID 8781432.
Airas L, Niemelä J, Salmi M, Puurunen T, Smith DJ, Jalkanen S (January 1997). "Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells". The Journal of Cell Biology. 136 (2): 421–31. doi:10.1083/jcb.136.2.421. PMC 2134816. PMID 9015312.
Strohmeier GR, Lencer WI, Patapoff TW, Thompson LF, Carlson SL, Moe SJ, Carnes DK, Mrsny RJ, Madara JL (June 1997). "Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia". The Journal of Clinical Investigation. 99 (11): 2588–601. doi:10.1172/JCI119447. PMC 508104. PMID 9169488.
Aumüller G, Renneberg H, Schiemann PJ, Wilhelm B, Seitz J, Konrad L, Wennemuth G (1998). "The role of apocrine released proteins in the post-testicular regulation of human sperm function". Advances in Experimental Medicine and Biology. 424: 193–219. doi:10.1007/978-1-4615-5913-9_39. PMID 9361795.
Rosi F, Agostinho AB, Carlucci F, Zanoni L, Porcelli B, Marinello E, Galieni P, Tabucchi A (1998). "Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase". Life Sciences. 62 (25): 2257–66. doi:10.1016/S0024-3205(98)00206-9. PMID 9651114.

External links

NT5E+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid2129526-1] Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y (August 1990). "Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form". European Journal of Biochemistry. 191 (3): 563–9. doi:10.1111/j.1432-1033.1990.tb19158.x. PMID 2129526.

[entrez-2] "Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)".

[St._HilaireZiegler2011-3] St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M (February 2011). "NT5E mutations and arterial calcifications". The New England Journal of Medicine. 364 (5): 432–42. doi:10.1056/NEJMoa0912923. PMC 3049958. PMID 21288095.

[4] Sharp J (March 1954). "Heredo-familial vascular and articular calcification". Annals of the Rheumatic Diseases. 13 (1): 15–27. doi:10.1136/ard.13.1.15. PMC 1030367. PMID 13149051.

[5] Online Mendelian Inheritance in Man (OMIM) 211800

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''5'-nucleotidase''' (5'-NT), also known as '''ecto-5'-nucleotidase''' or '''CD73''' ([[cluster of differentiation]] 73), is an [[enzyme]] that in humans is encoded by the ''NT5E'' [[gene]].<ref name="pmid2129526">{{cite journal | vauthors = Misumi Y, Ogata S, Ohkubo K, Hirose S, Ikehara Y | title = Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form | journal = European Journal of Biochemistry | volume = 191 | issue = 3 | pages = 563–9 | date = August 1990 | pmid = 2129526 | doi = 10.1111/j.1432-1033.1990.tb19158.x }}</ref> CD73 commonly serves to convert [[Adenosine monophosphate|AMP]] to [[adenosine]].
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = 5'-nucleotidase, ecto (CD73)
- | HGNCid = 8021
- | Symbol = NT5E
- | AltSymbols =; CD73; E5NT; NT; NT5; NTE; eN; eNT
- | OMIM = 129190
- | ECnumber =
- | Homologene = 1895
- | MGIid = 99782
- | GeneAtlas_image1 = PBB_GE_NT5E_203939_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0008253 |text = 5'-nucleotidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016788 |text = hydrolase activity, acting on ester bonds}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0009166 |text = nucleotide catabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4907
-    | Hs_Ensembl = ENSG00000135318
-    | Hs_RefseqProtein = NP_002517
-    | Hs_RefseqmRNA = NM_002526
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 86216528
-    | Hs_GenLoc_end = 86262215
-    | Hs_Uniprot = P21589
-    | Mm_EntrezGene = 23959
-    | Mm_Ensembl = ENSMUSG00000032420
-    | Mm_RefseqmRNA = NM_011851
-    | Mm_RefseqProtein = NP_035981
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 88125533
-    | Mm_GenLoc_end = 88169982
-    | Mm_Uniprot = Q0VEE0
-  }}
-}}
-'''5'-nucleotidase, ecto''' ('''NT5E'''), also known as '''CD73''' ('''C'''luster of '''D'''ifferentiation 73), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4907| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being [[adenosine monophosphate|AMP]]. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of [[lymphocyte]] differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.<ref name="entrez">{{cite web | title = Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4907| accessdate = }}</ref> Rare [[Phenotypic trait|allelic variant]]s are associated with a syndrome of adult-onset '''calcification of joints and arteries''' (CALJA) affecting the [[iliac artery (disambiguation)|iliac]], [[femoral artery|femoral]], and [[tibial arteries (disambiguation)|tibial arteries]] reducing circulation in the legs and the joints of the hands and feet causing pain.<ref name="St. HilaireZiegler2011">{{cite journal | vauthors = St Hilaire C, Ziegler SG, Markello TC, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA, Boehm M | title = NT5E mutations and arterial calcifications | journal = The New England Journal of Medicine | volume = 364 | issue = 5 | pages = 432–42 | date = February 2011 | pmid = 21288095 | pmc = 3049958 | doi = 10.1056/NEJMoa0912923 }}</ref><ref>{{cite journal | vauthors = Sharp J | title = Heredo-familial vascular and articular calcification | journal = Annals of the Rheumatic Diseases | volume = 13 | issue = 1 | pages = 15–27 | date = March 1954 | pmid = 13149051 | pmc = 1030367 | doi = 10.1136/ard.13.1.15 }}</ref><ref>{{OMIM|211800}}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text = Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NT5E 5'-nucleotidase, ecto (CD73)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4907| accessdate = }}</ref>
-}}
-==See also==
+== See also ==
 * [[Cluster of differentiation]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Resta R, Thompson LF | title = T cell signalling through CD73 | journal = Cellular Signalling | volume = 9 | issue = 2 | pages = 131–9 | date = February 1997 | pmid = 9113412 | doi = 10.1016/S0898-6568(96)00132-5 }}
-| citations =
+* {{cite journal | vauthors = Kirchhoff C, Hale G | title = Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation | journal = Molecular Human Reproduction | volume = 2 | issue = 3 | pages = 177–84 | date = March 1996 | pmid = 9238677 | doi = 10.1093/molehr/2.3.177 }}
-*{{cite journal  | author=Resta R, Thompson LF |title=T cell signalling through CD73. |journal=Cell. Signal. |volume=9 |issue= 2 |pages= 131-9 |year= 1997 |pmid= 9113412 |doi=  }}
+* {{cite journal | vauthors = Resta R, Yamashita Y, Thompson LF | title = Ecto-enzyme and signaling functions of lymphocyte CD73 | journal = Immunological Reviews | volume = 161 | issue =  | pages = 95–109 | date = February 1998 | pmid = 9553767 | doi = 10.1111/j.1600-065X.1998.tb01574.x }}
-*{{cite journal  | author=Kirchhoff C, Hale G |title=Cell-to-cell transfer of glycosylphosphatidylinositol-anchored membrane proteins during sperm maturation. |journal=Mol. Hum. Reprod. |volume=2 |issue= 3 |pages= 177-84 |year= 1997 |pmid= 9238677 |doi=  }}
+* {{cite journal | vauthors = Rosi F, Carlucci F, Marinello E, Tabucchi A | title = Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia | journal = Biomedicine & Pharmacotherapy | volume = 56 | issue = 2 | pages = 100–4 | date = March 2002 | pmid = 12000134 | doi = 10.1016/S0753-3322(01)00072-5 }}
-*{{cite journal  | author=Resta R, Yamashita Y, Thompson LF |title=Ecto-enzyme and signaling functions of lymphocyte CD73. |journal=Immunol. Rev. |volume=161 |issue=  |pages= 95-109 |year= 1998 |pmid= 9553767 |doi=  }}
+* {{cite journal | vauthors = Babiychuk EB, Draeger A | title = Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement? | journal = Biochemical Society Transactions | volume = 34 | issue = Pt 3 | pages = 374–6 | date = June 2006 | pmid = 16709165 | doi = 10.1042/BST0340374 }}
-*{{cite journal  | author=Rosi F, Carlucci F, Marinello E, Tabucchi A |title=Ecto-5'-nucleotidase in B-cell chronic lymphocytic leukemia. |journal=Biomed. Pharmacother. |volume=56 |issue= 2 |pages= 100-4 |year= 2002 |pmid= 12000134 |doi=  }}
+* {{cite journal | vauthors = Stefanovic V, Mandel P, Rosenberg A | title = Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells | journal = The Journal of Biological Chemistry | volume = 251 | issue = 13 | pages = 3900–5 | date = July 1976 | pmid = 819433 | doi =  }}
-*{{cite journal  | author=Babiychuk EB, Draeger A |title=Regulation of ecto-5'-nucleotidase activity via Ca2+-dependent, annexin 2-mediated membrane rearrangement? |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 374-6 |year= 2006 |pmid= 16709165 |doi= 10.1042/BST0340374 }}
+* {{cite journal | vauthors = Thomson LF, Ruedi JM, Glass A, Moldenhauer G, Moller P, Low MG, Klemens MR, Massaia M, Lucas AH | title = Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73) | journal = Tissue Antigens | volume = 35 | issue = 1 | pages = 9–19 | date = January 1990 | pmid = 2137649 | doi = 10.1111/j.1399-0039.1990.tb01750.x }}
-*{{cite journal  | author=Stefanovic V, Mandel P, Rosenberg A |title=Ecto-5'-nucleotidase of intact cultured C6 rat glioma cells. |journal=J. Biol. Chem. |volume=251 |issue= 13 |pages= 3900-5 |year= 1976 |pmid= 819433 |doi=  }}
+* {{cite journal | vauthors = Klemens MR, Sherman WR, Holmberg NJ, Ruedi JM, Low MG, Thompson LF | title = Characterization of soluble vs membrane-bound human placental 5'-nucleotidase | journal = Biochemical and Biophysical Research Communications | volume = 172 | issue = 3 | pages = 1371–7 | date = November 1990 | pmid = 2173922 | doi = 10.1016/0006-291X(90)91601-N }}
-*{{cite journal  | author=Misumi Y, Ogata S, Ohkubo K, ''et al.'' |title=Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form. |journal=Eur. J. Biochem. |volume=191 |issue= 3 |pages= 563-9 |year= 1990 |pmid= 2129526 |doi=  }}
+* {{cite journal | vauthors = Boyle JM, Hey Y, Guerts van Kessel A, Fox M | title = Assignment of ecto-5'-nucleotidase to human chromosome 6 | journal = Human Genetics | volume = 81 | issue = 1 | pages = 88–92 | date = December 1988 | pmid = 2848759 | doi = 10.1007/BF00283737 }}
-*{{cite journal  | author=Thomson LF, Ruedi JM, Glass A, ''et al.'' |title=Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73). |journal=Tissue Antigens |volume=35 |issue= 1 |pages= 9-19 |year= 1990 |pmid= 2137649 |doi=  }}
+* {{cite journal | vauthors = Vlahović P, Stefanović V | title = Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells | journal = Archives Internationales De Physiologie, De Biochimie Et De Biophysique | volume = 102 | issue = 3 | pages = 171–3 | year = 1995 | pmid = 8000038 | doi =  }}
-*{{cite journal  | author=Klemens MR, Sherman WR, Holmberg NJ, ''et al.'' |title=Characterization of soluble vs membrane-bound human placental 5'-nucleotidase. |journal=Biochem. Biophys. Res. Commun. |volume=172 |issue= 3 |pages= 1371-7 |year= 1990 |pmid= 2173922 |doi=  }}
+* {{cite journal | vauthors = Hansen KR, Resta R, Webb CF, Thompson LF | title = Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene | journal = Gene | volume = 167 | issue = 1-2 | pages = 307–12 | date = December 1995 | pmid = 8566797 | doi = 10.1016/0378-1119(95)00574-9 }}
-*{{cite journal  | author=Boyle JM, Hey Y, Guerts van Kessel A, Fox M |title=Assignment of ecto-5'-nucleotidase to human chromosome 6. |journal=Hum. Genet. |volume=81 |issue= 1 |pages= 88-92 |year= 1989 |pmid= 2848759 |doi=  }}
+* {{cite journal | vauthors = Airas L, Jalkanen S | title = CD73 mediates adhesion of B cells to follicular dendritic cells | journal = Blood | volume = 88 | issue = 5 | pages = 1755–64 | date = September 1996 | pmid = 8781432 | doi =  }}
-*{{cite journal  | author=Vlahović P, Stefanović V |title=Effect of dopamine on ecto-5'-nucleotidase expression in human glomerular mesangial cells. |journal=Archives internationales de physiologie, de biochimie et de biophysique |volume=102 |issue= 3 |pages= 171-3 |year= 1995 |pmid= 8000038 |doi=  }}
+* {{cite journal | vauthors = Airas L, Niemelä J, Salmi M, Puurunen T, Smith DJ, Jalkanen S | title = Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells | journal = The Journal of Cell Biology | volume = 136 | issue = 2 | pages = 421–31 | date = January 1997 | pmid = 9015312 | pmc = 2134816 | doi = 10.1083/jcb.136.2.421 }}
-*{{cite journal  | author=Hansen KR, Resta R, Webb CF, Thompson LF |title=Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene. |journal=Gene |volume=167 |issue= 1-2 |pages= 307-12 |year= 1996 |pmid= 8566797 |doi=  }}
+* {{cite journal | vauthors = Strohmeier GR, Lencer WI, Patapoff TW, Thompson LF, Carlson SL, Moe SJ, Carnes DK, Mrsny RJ, Madara JL | title = Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia | journal = The Journal of Clinical Investigation | volume = 99 | issue = 11 | pages = 2588–601 | date = June 1997 | pmid = 9169488 | pmc = 508104 | doi = 10.1172/JCI119447 }}
-*{{cite journal  | author=Airas L, Jalkanen S |title=CD73 mediates adhesion of B cells to follicular dendritic cells. |journal=Blood |volume=88 |issue= 5 |pages= 1755-64 |year= 1996 |pmid= 8781432 |doi=  }}
+* {{cite journal | vauthors = Aumüller G, Renneberg H, Schiemann PJ, Wilhelm B, Seitz J, Konrad L, Wennemuth G | title = The role of apocrine released proteins in the post-testicular regulation of human sperm function | journal = Advances in Experimental Medicine and Biology | volume = 424 | issue =  | pages = 193–219 | year = 1998 | pmid = 9361795 | doi = 10.1007/978-1-4615-5913-9_39 }}
-*{{cite journal  | author=Airas L, Niemelä J, Salmi M, ''et al.'' |title=Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. |journal=J. Cell Biol. |volume=136 |issue= 2 |pages= 421-31 |year= 1997 |pmid= 9015312 |doi=  }}
+* {{cite journal | vauthors = Rosi F, Agostinho AB, Carlucci F, Zanoni L, Porcelli B, Marinello E, Galieni P, Tabucchi A | title = Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase | journal = Life Sciences | volume = 62 | issue = 25 | pages = 2257–66 | year = 1998 | pmid = 9651114 | doi = 10.1016/S0024-3205(98)00206-9 }}
-*{{cite journal  | author=Strohmeier GR, Lencer WI, Patapoff TW, ''et al.'' |title=Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. |journal=J. Clin. Invest. |volume=99 |issue= 11 |pages= 2588-601 |year= 1997 |pmid= 9169488 |doi=  }}
-*{{cite journal  | author=Aumüller G, Renneberg H, Schiemann PJ, ''et al.'' |title=The role of apocrine released proteins in the post-testicular regulation of human sperm function. |journal=Adv. Exp. Med. Biol. |volume=424 |issue=  |pages= 193-219 |year= 1998 |pmid= 9361795 |doi=  }}
-*{{cite journal  | author=Rosi F, Agostinho AB, Carlucci F, ''et al.'' |title=Behaviour of human lymphocytic isoenzymes of 5'-nucleotidase. |journal=Life Sci. |volume=62 |issue= 25 |pages= 2257-66 |year= 1998 |pmid= 9651114 |doi=  }}
-}}
 {{refend}}
-==External links==
+== External links ==
 * {{MeshName|NT5E+protein,+human}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Clusters of differentiation}}
 [[Category:Clusters of differentiation]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

NT5E: Difference between revisions

Latest revision as of 13:17, 5 September 2017

Contents

Function

See also

References

Further reading

External links

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