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{{ | '''Programmed cell death 1 ligand 2''' (also known as PD-L2, B7-DC) is a [[protein]] that in humans is encoded by the ''PDCD1LG2'' [[gene]].<ref name="pmid11224527">{{cite journal | vauthors = Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ | title = PD-L2 is a second ligand for PD-1 and inhibits T cell activation | journal = Nat Immunol | volume = 2 | issue = 3 | pages = 261–8 |date=Mar 2001 | pmid = 11224527 | pmc = | doi = 10.1038/85330 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80380| accessdate = }}</ref> PDCD1LG2 has also been designated as '''CD273''' ([[cluster of differentiation]] 273). | ||
}} | |||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
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| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Tseng SY, Otsuji M, Gorski K, etal |title=B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. |journal=J. Exp. Med. |volume=193 |issue= 7 |pages= 839–46 |year= 2001 |pmid= 11283156 |doi=10.1084/jem.193.7.839 | pmc=2193370 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal | *{{cite journal |vauthors=Brown JA, Dorfman DM, Ma FR, etal |title=Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. |journal=J. Immunol. |volume=170 |issue= 3 |pages= 1257–66 |year= 2003 |pmid= 12538684 |doi= 10.4049/jimmunol.170.3.1257}} | ||
*{{cite journal | *{{cite journal |vauthors=Youngnak P, Kozono Y, Kozono H, etal |title=Differential binding properties of B7-H1 and B7-DC to programmed death-1. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 672–7 |year= 2003 |pmid= 12893276 |doi=10.1016/S0006-291X(03)01257-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Tsushima F, Iwai H, Otsuki N, etal |title=Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. |journal=Eur. J. Immunol. |volume=33 |issue= 10 |pages= 2773–82 |year= 2003 |pmid= 14515261 |doi= 10.1002/eji.200324084 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Aramaki O, Shirasugi N, Takayama T, etal |title=Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. |journal=Transplantation |volume=77 |issue= 1 |pages= 6–12 |year= 2004 |pmid= 14724428 |doi= 10.1097/01.TP.0000108637.65091.4B }} | ||
*{{cite journal | *{{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }} | ||
*{{cite journal | *{{cite journal | vauthors=He XH, Liu Y, Xu LH, Zeng YY |title=Cloning and identification of two novel splice variants of human PD-L2. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 4 |pages= 284–9 |year= 2004 |pmid= 15253154 |doi=10.1093/abbs/36.4.284 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ohigashi Y, Sho M, Yamada Y, etal |title=Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. |journal=Clin. Cancer Res. |volume=11 |issue= 8 |pages= 2947–53 |year= 2005 |pmid= 15837746 |doi= 10.1158/1078-0432.CCR-04-1469 }} | ||
*{{cite journal | *{{cite journal | vauthors=Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML |title=PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. |journal=Eur. J. Immunol. |volume=35 |issue= 12 |pages= 3561–9 |year= 2006 |pmid= 16278812 |doi= 10.1002/eji.200526347 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Pfistershammer K, Klauser C, Pickl WF, etal |title=No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. |journal=Eur. J. Immunol. |volume=36 |issue= 5 |pages= 1104–13 |year= 2006 |pmid= 16598819 | pmc=2975063 |doi= 10.1002/eji.200535344 }} | ||
*{{cite journal | *{{cite journal |vauthors=Abelson AK, Johansson CM, Kozyrev SV, etal |title=No evidence of association between genetic variants of the PDCD1 ligands and SLE. |journal=Genes Immun. |volume=8 |issue= 1 |pages= 69–74 |year= 2007 |pmid= 17136123 |doi= 10.1038/sj.gene.6364360 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mataki N, Kikuchi K, Kawai T, etal |title=Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases. |journal=Am. J. Gastroenterol. |volume=102 |issue= 2 |pages= 302–12 |year= 2007 |pmid= 17311651 |doi= 10.1111/j.1572-0241.2006.00948.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Wang SC, Lin CH, Ou TT, etal |title=Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. |journal=J. Rheumatol. |volume=34 |issue= 4 |pages= 721–5 |year= 2007 |pmid= 17343323 |doi=10.1093/rheumatology/34.8.721 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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* {{MeshName|PDCD1LG2+protein,+human}} | * {{MeshName|PDCD1LG2+protein,+human}} | ||
{{ | {{B7 family}} | ||
{{Clusters of differentiation}} | {{Clusters of differentiation}} | ||
[[Category:Clusters of differentiation]] | [[Category:Clusters of differentiation]] | ||
{{ | |||
{{membrane-protein-stub}} |
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Wikidata | |||||||
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Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.[1][2] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).
References
- ↑ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.
- ↑ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".
Further reading
- Tseng SY, Otsuji M, Gorski K, et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells". J. Exp. Med. 193 (7): 839–46. doi:10.1084/jem.193.7.839. PMC 2193370. PMID 11283156.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production". J. Immunol. 170 (3): 1257–66. doi:10.4049/jimmunol.170.3.1257. PMID 12538684.
- Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1". Biochem. Biophys. Res. Commun. 307 (3): 672–7. doi:10.1016/S0006-291X(03)01257-9. PMID 12893276.
- Tsushima F, Iwai H, Otsuki N, et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses". Eur. J. Immunol. 33 (10): 2773–82. doi:10.1002/eji.200324084. PMID 14515261.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Aramaki O, Shirasugi N, Takayama T, et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen". Transplantation. 77 (1): 6–12. doi:10.1097/01.TP.0000108637.65091.4B. PMID 14724428.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2". Acta Biochim. Biophys. Sin. (Shanghai). 36 (4): 284–9. doi:10.1093/abbs/36.4.284. PMID 15253154.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ohigashi Y, Sho M, Yamada Y, et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer". Clin. Cancer Res. 11 (8): 2947–53. doi:10.1158/1078-0432.CCR-04-1469. PMID 15837746.
- Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion". Eur. J. Immunol. 35 (12): 3561–9. doi:10.1002/eji.200526347. PMID 16278812.
- Pfistershammer K, Klauser C, Pickl WF, et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation". Eur. J. Immunol. 36 (5): 1104–13. doi:10.1002/eji.200535344. PMC 2975063. PMID 16598819.
- Abelson AK, Johansson CM, Kozyrev SV, et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE". Genes Immun. 8 (1): 69–74. doi:10.1038/sj.gene.6364360. PMID 17136123.
- Mataki N, Kikuchi K, Kawai T, et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases". Am. J. Gastroenterol. 102 (2): 302–12. doi:10.1111/j.1572-0241.2006.00948.x. PMID 17311651.
- Wang SC, Lin CH, Ou TT, et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus". J. Rheumatol. 34 (4): 721–5. doi:10.1093/rheumatology/34.8.721. PMID 17343323.
External links
- PDCD1LG2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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