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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Receptor-type tyrosine-protein phosphatase zeta''' also known as '''phosphacan''' is an [[enzyme]] that in humans is encoded by the ''PTPRZ1'' [[gene]].<ref name="pmid7736789">{{cite journal | vauthors = Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H | title = Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3 | journal = Cytogenet Cell Genet | volume = 70 | issue = 1–2 | pages = 52–4 | date = Jun 1995 | pmid = 7736789 | pmc =  | doi = 10.1159/000133990 }}</ref><ref name="pmid8387522">{{cite journal | vauthors = Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T | title = The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system | journal = J Biol Chem | volume = 268 | issue = 14 | pages = 10573–81 | date = Jun 1993 | pmid = 8387522 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5803| accessdate = }}</ref>
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
| HGNCid = 9685
| Symbol = PTPRZ1
| AltSymbols =; HPTPZ; HPTPzeta; PTP18; PTPRZ; PTPZ; RPTPB; RPTPbeta; phosphacan
| OMIM = 176891
| ECnumber = 
| Homologene = 2136
| MGIid = 97816
| GeneAtlas_image1 = PBB_GE_PTPRZ1_204469_at_tn.png
| Function = {{GNF_GO|id=GO:0004089 |text = carbonate dehydratase activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5803
    | Hs_Ensembl = ENSG00000106278
    | Hs_RefseqProtein = NP_002842
    | Hs_RefseqmRNA = NM_002851
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 121300643
    | Hs_GenLoc_end = 121489324
    | Hs_Uniprot = P23471
    | Mm_EntrezGene = 19283
    | Mm_Ensembl = ENSMUSG00000068748
    | Mm_RefseqmRNA = XM_620293
    | Mm_RefseqProtein = XP_620293
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 22825828
    | Mm_GenLoc_end = 23002110
    | Mm_Uniprot = 
  }}
}}
'''Protein tyrosine phosphatase, receptor-type, Z polypeptide 1''', also known as '''PTPRZ1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5803| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[receptor tyrosine phosphatase]] family and encodes a single-pass type I membrane protein with two [[cytoplasm]]ic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a [[fibronectin type III domain]]. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the receptor type protein tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type-III domain. Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5803| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Expression of this gene is induced in [[stomach cancer|gastric cancer]] cells, in the remyelinating [[oligodendrocytes]] of multiple sclerosis lesions, and in human embryonic kidney cells under [[hypoxia (medical)|hypoxic]] conditions. Both the protein and transcript are overexpressed in [[glioblastoma]] cells, promoting their haptotactic migration.<ref name="entrez"/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Krueger NX, Saito H | title = A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 16 | pages = 7417–21 | year = 1992 | pmid = 1323835 | pmc = 49721 | doi = 10.1073/pnas.89.16.7417 }}
| citations =
* {{cite journal | vauthors = Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J | title = Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 18 | pages = 7000–4 | year = 1990 | pmid = 2169617 | pmc = 54670 | doi = 10.1073/pnas.87.18.7000 }}
*{{cite journal | author=Krueger NX, Saito H |title=A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 16 |pages= 7417-21 |year= 1992 |pmid= 1323835 |doi= }}
* {{cite journal | vauthors = Krueger NX, Streuli M, Saito H | title = Structural diversity and evolution of human receptor-like protein tyrosine phosphatases | journal = EMBO J. | volume = 9 | issue = 10 | pages = 3241–52 | year = 1990 | pmid = 2170109 | pmc = 552056 | doi =  }}
*{{cite journal | author=Kaplan R, Morse B, Huebner K, ''et al.'' |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000-4 |year= 1990 |pmid= 2169617 |doi= }}
* {{cite journal | vauthors = Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, Donis-Keller H | title = Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s | journal = Genomics | volume = 46 | issue = 3 | pages = 491–4 | year = 1998 | pmid = 9441757 | doi = 10.1006/geno.1997.5051 }}
*{{cite journal  | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241-52 |year= 1990 |pmid= 2170109 |doi=  }}
* {{cite journal | vauthors = Onyango P, Lubyova B, Gardellin P, Kurzbauer R, Weith A | title = Molecular cloning and expression analysis of five novel genes in chromosome 1p36 | journal = Genomics | volume = 50 | issue = 2 | pages = 187–98 | year = 1998 | pmid = 9653645 | doi = 10.1006/geno.1997.5186 }}
*{{cite journal | author=Ariyama T, Hasegawa K, Inazawa J, ''et al.'' |title=Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 1-2 |pages= 52-4 |year= 1995 |pmid= 7736789 |doi= }}
* {{cite journal | vauthors = | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1999 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
*{{cite journal | author=Levy JB, Canoll PD, Silvennoinen O, ''et al.'' |title=The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. |journal=J. Biol. Chem. |volume=268 |issue= 14 |pages= 10573-81 |year= 1993 |pmid= 8387522 |doi= }}
* {{cite journal | vauthors = Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M | title = A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta | journal = J. Biol. Chem. | volume = 274 | issue = 18 | pages = 12474–9 | year = 1999 | pmid = 10212223 | doi = 10.1074/jbc.274.18.12474 }}
*{{cite journal  | author=Morton SM, Veile RA, Helms C, ''et al.'' |title=Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s. |journal=Genomics |volume=46 |issue= 3 |pages= 491-4 |year= 1998 |pmid= 9441757 |doi= 10.1006/geno.1997.5051 }}
* {{cite journal | vauthors = Kawachi H, Tamura H, Watakabe I, Shintani T, Maeda N, Noda M | title = Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family | journal = Brain Res. Mol. Brain Res. | volume = 72 | issue = 1 | pages = 47–54 | year = 1999 | pmid = 10521598 | doi = 10.1016/S0169-328X(99)00204-1 }}
*{{cite journal | author=Onyango P, Lubyova B, Gardellin P, ''et al.'' |title=Molecular cloning and expression analysis of five novel genes in chromosome 1p36. |journal=Genomics |volume=50 |issue= 2 |pages= 187-98 |year= 1998 |pmid= 9653645 |doi= 10.1006/geno.1997.5186 }}
* {{cite journal | vauthors = Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M, Deuel TF | title = Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 6 | pages = 2603–8 | year = 2000 | pmid = 10706604 | pmc = 15975 | doi = 10.1073/pnas.020487997 }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
* {{cite journal | vauthors = Kawachi H, Fujikawa A, Maeda N, Noda M | title = Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 12 | pages = 6593–8 | year = 2001 | pmid = 11381105 | pmc = 34398 | doi = 10.1073/pnas.041608698 }}
*{{cite journal | author=Maeda N, Ichihara-Tanaka K, Kimura T, ''et al.'' |title=A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12474-9 |year= 1999 |pmid= 10212223 |doi= }}
* {{cite journal | vauthors = Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R | title = Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells | journal = J. Neurochem. | volume = 78 | issue = 4 | pages = 767–78 | year = 2001 | pmid = 11520897 | doi = 10.1046/j.1471-4159.2001.00454.x }}
*{{cite journal | author=Kawachi H, Tamura H, Watakabe I, ''et al.'' |title=Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family. |journal=Brain Res. Mol. Brain Res. |volume=72 |issue= 1 |pages= 47-54 |year= 1999 |pmid= 10521598 |doi= }}
* {{cite journal | vauthors = Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J | title = A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions | journal = Nat. Genet. | volume = 32 | issue = 3 | pages = 411–4 | year = 2002 | pmid = 12355066 | doi = 10.1038/ng1004 }}
*{{cite journal | author=Meng K, Rodriguez-Peña A, Dimitrov T, ''et al.'' |title=Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2603-8 |year= 2000 |pmid= 10706604 |doi= 10.1073/pnas.020487997 }}
* {{cite journal | vauthors = Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson AM, von Schack D, Chin DJ, Lohr SC, Westphal M, Melcher T | title = A role for receptor tyrosine phosphatase zeta in glioma cell migration | journal = Oncogene | volume = 22 | issue = 43 | pages = 6661–8 | year = 2003 | pmid = 14555979 | doi = 10.1038/sj.onc.1206763 }}
*{{cite journal | author=Kawachi H, Fujikawa A, Maeda N, Noda M |title=Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 12 |pages= 6593-8 |year= 2001 |pmid= 11381105 |doi= 10.1073/pnas.041608698 }}
* {{cite journal | vauthors = Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, van Engeland H, de Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP | title = Mutation screening and association analysis of six candidate genes for autism on chromosome 7q | journal = Eur. J. Hum. Genet. | volume = 13 | issue = 2 | pages = 198–207 | year = 2005 | pmid = 15523497 | doi = 10.1038/sj.ejhg.5201315 }}
*{{cite journal | author=Thomaidou D, Coquillat D, Meintanis S, ''et al.'' |title=Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells. |journal=J. Neurochem. |volume=78 |issue= 4 |pages= 767-78 |year= 2001 |pmid= 11520897 |doi= }}
* {{cite journal | vauthors = Polykratis A, Katsoris P, Courty J, Papadimitriou E | title = Characterization of heparin affin regulatory peptide signaling in human endothelial cells | journal = J. Biol. Chem. | volume = 280 | issue = 23 | pages = 22454–61 | year = 2005 | pmid = 15797857 | doi = 10.1074/jbc.M414407200 }}
*{{cite journal | author=Harroch S, Furtado GC, Brueck W, ''et al.'' |title=A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions. |journal=Nat. Genet. |volume=32 |issue= 3 |pages= 411-4 |year= 2002 |pmid= 12355066 |doi= 10.1038/ng1004 }}
* {{cite journal | vauthors = Wang V, Davis DA, Haque M, Huang LE, Yarchoan R | title = Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells | journal = Cancer Res. | volume = 65 | issue = 8 | pages = 3299–306 | year = 2005 | pmid = 15833863 | doi = 10.1158/0008-5472.CAN-04-4130 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
* {{cite journal | vauthors = Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang MY, [[Timothy Cloughesy|Cloughesy TF]], Nelson SF, Mischel PS | title = Differential induction of glioblastoma migration and growth by two forms of pleiotrophin | journal = J. Biol. Chem. | volume = 280 | issue = 29 | pages = 26953–64 | year = 2005 | pmid = 15908427 | doi = 10.1074/jbc.M502614200 }}
*{{cite journal | author=Müller S, Kunkel P, Lamszus K, ''et al.'' |title=A role for receptor tyrosine phosphatase zeta in glioma cell migration. |journal=Oncogene |volume=22 |issue= 43 |pages= 6661-8 |year= 2003 |pmid= 14555979 |doi= 10.1038/sj.onc.1206763 }}
*{{cite journal | author=Bonora E, Lamb JA, Barnby G, ''et al.'' |title=Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 2 |pages= 198-207 |year= 2005 |pmid= 15523497 |doi= 10.1038/sj.ejhg.5201315 }}
*{{cite journal  | author=Polykratis A, Katsoris P, Courty J, Papadimitriou E |title=Characterization of heparin affin regulatory peptide signaling in human endothelial cells. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22454-61 |year= 2005 |pmid= 15797857 |doi= 10.1074/jbc.M414407200 }}
*{{cite journal  | author=Wang V, Davis DA, Haque M, ''et al.'' |title=Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. |journal=Cancer Res. |volume=65 |issue= 8 |pages= 3299-306 |year= 2005 |pmid= 15833863 |doi= 10.1158/0008-5472.CAN-04-4130 }}
*{{cite journal  | author=Lu KV, Jong KA, Kim GY, ''et al.'' |title=Differential induction of glioblastoma migration and growth by two forms of pleiotrophin. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26953-64 |year= 2005 |pmid= 15908427 |doi= 10.1074/jbc.M502614200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
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Latest revision as of 17:20, 16 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.[1][2][3]

Function

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[3]

Clinical significance

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[3]

References

  1. ↑ Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet. 70 (1–2): 52–4. doi:10.1159/000133990. PMID 7736789.
  2. ↑ Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA, Park SH, Druck T (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem. 268 (14): 10573–81. PMID 8387522.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PTPRZ1&oldid=1533747"