TLR6: Difference between revisions

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{{Infobox_gene}}
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'''Toll-like receptor 6''' is a [[protein]] that in humans is encoded by the ''TLR6'' [[gene]].<ref name="pmid10231569">{{cite journal | vauthors = Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S | title = TLR6: A novel member of an expanding toll-like receptor family | journal = Gene | volume = 231 | issue = 1–2 | pages = 59–65 |date=Jun 1999 | pmid = 10231569 | pmc = | doi =10.1016/S0378-1119(99)00098-0 }}</ref> TLR6 has also been designated as '''CD286''' ([[cluster of differentiation]] 286).
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Toll-like receptor 6
| HGNCid = 16711
| Symbol = TLR6
| AltSymbols =;
| OMIM = 605403
| ECnumber = 
| Homologene = 21223
| MGIid = 1341296
| GeneAtlas_image1 = PBB_GE_TLR6_207446_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008034 |text = lipoprotein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045335 |text = phagocytic vesicle}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007250 |text = activation of NF-kappaB-inducing kinase}} {{GNF_GO|id=GO:0042088 |text = T-helper 1 type immune response}} {{GNF_GO|id=GO:0042116 |text = macrophage activation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045084 |text = positive regulation of interleukin-12 biosynthetic process}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045410 |text = positive regulation of interleukin-6 biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10333
    | Hs_Ensembl = ENSG00000174130
    | Hs_RefseqProtein = NP_006059
    | Hs_RefseqmRNA = NM_006068
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 38504618
    | Hs_GenLoc_end = 38507555
    | Hs_Uniprot = Q9Y2C9
    | Mm_EntrezGene = 21899
    | Mm_Ensembl = ENSMUSG00000051498
    | Mm_RefseqmRNA = NM_011604
    | Mm_RefseqProtein = NP_035734
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 65232241
    | Mm_GenLoc_end = 65239170
    | Mm_Uniprot = Q0PM14
  }}
}}
'''Toll-like receptor 6''', also known as '''TLR6''', is a human [[gene]].


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.<ref>{{cite web | title = Entrez Gene: TLR6 toll-like receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10333| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[toll-like receptor]] (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.<ref>{{cite web | title = Entrez Gene: TLR6 toll-like receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10333| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
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{{refbegin | 2}}
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| citations =  
| citations =  
*{{cite journal  | author=Lien E, Ingalls RR |title=Toll-like receptors. |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1-11 |year= 2002 |pmid= 11782555 |doi=  }}
*{{cite journal  | vauthors=Lien E, Ingalls RR |title=Toll-like receptors |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1–11 |year= 2002 |pmid= 11782555 |doi=10.1097/00003246-200201001-00001 }}
}}
}}
{{refend}}
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==External links==
==External links==
* {{MeshName|Toll-Like+Receptor+6}}
* {{MeshName|Toll-Like+Receptor+6}}
* {{UCSC genome browser|TLR6}}
* {{UCSC gene details|TLR6}}


{{biochem-stub}}
{{Clusters of differentiation}}
{{Immune receptors}}
{{TLR signaling pathway}}
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[[Category:Clusters of differentiation]]
[[Category:Toll-like receptors|6]]
[[Category:Toll-like receptors|6]]
[[Category:Immune system]]
{{protein-stub}}


[[tr:TLR6]]
 
{{WikiDoc Sources}}
{{gene-4-stub}}
{{biochem-stub}}

Latest revision as of 00:10, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.[1] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.[2]

References

  1. ↑ Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene. 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.
  2. ↑ "Entrez Gene: TLR6 toll-like receptor 6".

Further reading

External links


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