BTLA: Difference between revisions

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{{Infobox_gene}}
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'''B- and T-lymphocyte attenuator''' is a [[protein]] that in humans is encoded by the ''BTLA'' [[gene]].<ref name="pmid12796776">{{cite journal | vauthors = Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM | title = BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | journal = Nat Immunol | volume = 4 | issue = 7 | pages = 670–9 |date=Jun 2003 | pmid = 12796776 | pmc =  | doi = 10.1038/ni944 }}</ref><ref name="entrez"/> BTLA has also been designated as '''CD272''' ([[cluster of differentiation]] 272).
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== Function ==
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BTLA expression is induced during activation of [[T cell]]s, and BTLA remains expressed on [[T helper cell#Recognition .28Signal 1.29|Th1]] cells but not [[T helper cell#Verification .28Signal 2.29|Th2]] cells. Like [[PDCD1|PD1]] and [[CTLA4]], BTLA interacts with a B7 homolog, [[VTCN1|B7H4]].<ref name="entrez">{{cite web | title = Entrez Gene: BTLA B and T lymphocyte associated| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151888| accessdate = }}</ref> However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors ([[tumour necrosis factor receptor|TNF-R]]), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 ([[TNFRSF14]]), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image = PBB_Protein_BTLA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2aw2.
| PDB = {{PDB2|2aw2}}
| Name = B and T lymphocyte attenuator
| HGNCid = 21087
| Symbol = BTLA
| AltSymbols =; BTLA1; CD272; FLJ16065; MGC129743
| OMIM = 607925
| ECnumber = 
| Homologene = 52233
| MGIid = 2658978
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0030889 |text = negative regulation of B cell proliferation}} {{GNF_GO|id=GO:0042130 |text = negative regulation of T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 151888
    | Hs_Ensembl = ENSG00000186265
    | Hs_RefseqProtein = NP_861445
    | Hs_RefseqmRNA = NM_181780
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 113667464
    | Hs_GenLoc_end = 113701066
    | Hs_Uniprot = Q7Z6A9
    | Mm_EntrezGene = 208154
    | Mm_Ensembl = ENSMUSG00000052013
    | Mm_RefseqmRNA = NM_001037719
    | Mm_RefseqProtein = NP_001032808
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 45143647
    | Mm_GenLoc_end = 45172227
    | Mm_Uniprot = Q32MV8
  }}
}}
'''B and T lymphocyte attenuator''', also known as '''BTLA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BTLA B and T lymphocyte associated| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151888| accessdate = }}</ref> BTLA has also been designated as '''CD272''' ([[cluster of differentiation]] 272).


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BTLA activation inhibits the function of human [[CD8]]<sup>+</sup> cancer-specific T cells.<ref name="Derré_2009">{{cite journal |vauthors = Derré L, ((Rivals J-P)), Jandus C, Pastor S, Rimoldi D, Romero P, Michielin O, Olive D, Speiser DE|title = BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination|journal = J Clin Invest|volume = 120|issue = 1|pages = 157–67|year = 2009|pmid = 20038811|doi = 10.1172/JCI40070|url = http://www.jci.org/articles/view/40070|laysummary = http://www.genengnews.com/news/bnitem.aspx?name=72101852&source=genwire|laysource = [[Gen. Eng. Biotechnol. News|Genetic Engineering & Biotechnology News]]|pmc = 2799219}}</ref>
{{PBB_Summary
| section_title =
| summary_text = BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 (MIM 600244) and CTLA4 (MIM 123890), BTLA interacts with a B7 homolog, B7H4.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: BTLA B and T lymphocyte associated| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151888| accessdate = }}</ref> However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family (TNF) receptors, not just the B7 family of cell surface receptors. BTLA is a ligand for [[TNFSF14|tumour necrosis factor (ligand) superfamily, member 14]] (TNFSF14), also known as herpes virus etry mdiator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
}}


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Pao LI, Bedzyk WD, Persin C, Cambier JC |title=Molecular targets of CD45 in B cell antigen receptor signal transduction. |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1116-24 |year= 1997 |pmid= 9013950 |doi=  }}
*{{cite journal  | vauthors=Pao LI, Bedzyk WD, Persin C, Cambier JC |title=Molecular targets of CD45 in B cell antigen receptor signal transduction |journal=J. Immunol. |volume=158 |issue= 3 |pages= 1116–24 |year= 1997 |pmid= 9013950 |doi=  }}
*{{cite journal  | author=Pao LI, Cambier JC |title=Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2663-9 |year= 1997 |pmid= 9058799 |doi=  }}
*{{cite journal  | vauthors=Pao LI, Cambier JC |title=Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2663–9 |year= 1997 |pmid= 9058799 |doi=  }}
*{{cite journal  | author=Vilen BJ, Famiglietti SJ, Carbone AM, ''et al.'' |title=B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. |journal=J. Immunol. |volume=159 |issue= 1 |pages= 231-43 |year= 1997 |pmid= 9200459 |doi=  }}
*{{cite journal  | vauthors=Vilen BJ, Famiglietti SJ, Carbone AM |title=B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation |journal=J. Immunol. |volume=159 |issue= 1 |pages= 231–43 |year= 1997 |pmid= 9200459 |doi=  |display-authors=etal}}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Watanabe N, Gavrieli M, Sedy JR, ''et al.'' |title=BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. |journal=Nat. Immunol. |volume=4 |issue= 7 |pages= 670-9 |year= 2003 |pmid= 12796776 |doi= 10.1038/ni944 }}
*{{cite journal  | vauthors=Gavrieli M, Watanabe N, Loftin SK |title=Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2 |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1236–43 |year= 2004 |pmid= 14652006 |doi=10.1016/j.bbrc.2003.11.070 |display-authors=etal}}
*{{cite journal  | author=Gavrieli M, Watanabe N, Loftin SK, ''et al.'' |title=Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 1236-43 |year= 2004 |pmid= 14652006 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Sedy JR, Gavrieli M, Potter KG |title=B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator |journal=Nat. Immunol. |volume=6 |issue= 1 |pages= 90–8 |year= 2005 |pmid= 15568026 |doi= 10.1038/ni1144 |display-authors=etal}}
*{{cite journal  | author=Sedy JR, Gavrieli M, Potter KG, ''et al.'' |title=B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. |journal=Nat. Immunol. |volume=6 |issue= 1 |pages= 90-8 |year= 2005 |pmid= 15568026 |doi= 10.1038/ni1144 }}
*{{cite journal  | vauthors=Gonzalez LC, Loyet KM, Calemine-Fenaux J |title=A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 4 |pages= 1116–21 |year= 2005 |pmid= 15647361 |doi= 10.1073/pnas.0409071102 | pmc=544343 |display-authors=etal}}
*{{cite journal  | author=Gonzalez LC, Loyet KM, Calemine-Fenaux J, ''et al.'' |title=A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 4 |pages= 1116-21 |year= 2005 |pmid= 15647361 |doi= 10.1073/pnas.0409071102 }}
*{{cite journal  | vauthors=Cheung TC, Humphreys IR, Potter KG |title=Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13218–23 |year= 2005 |pmid= 16131544 |doi= 10.1073/pnas.0506172102 | pmc=1201609 |display-authors=etal}}
*{{cite journal  | author=Cheung TC, Humphreys IR, Potter KG, ''et al.'' |title=Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13218-23 |year= 2005 |pmid= 16131544 |doi= 10.1073/pnas.0506172102 }}
*{{cite journal  | vauthors=Compaan DM, Gonzalez LC, Tom I |title=Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39553–61 |year= 2006 |pmid= 16169851 |doi= 10.1074/jbc.M507629200 |display-authors=etal}}
*{{cite journal  | author=Compaan DM, Gonzalez LC, Tom I, ''et al.'' |title=Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39553-61 |year= 2006 |pmid= 16169851 |doi= 10.1074/jbc.M507629200 }}
*{{cite journal  | vauthors=Otsuki N, Kamimura Y, Hashiguchi M, Azuma M |title=Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 4 |pages= 1121–7 |year= 2006 |pmid= 16643847 |doi= 10.1016/j.bbrc.2006.03.242 }}
*{{cite journal  | author=Otsuki N, Kamimura Y, Hashiguchi M, Azuma M |title=Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 4 |pages= 1121-7 |year= 2006 |pmid= 16643847 |doi= 10.1016/j.bbrc.2006.03.242 }}
*{{cite journal  | vauthors=Wang XF, Chen YJ, Wang Q |title=Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells |journal=Tissue Antigens |volume=69 |issue= 2 |pages= 145–53 |year= 2007 |pmid= 17257317 |doi= 10.1111/j.1399-0039.2006.00710.x |display-authors=etal}}
*{{cite journal  | author=Wang XF, Chen YJ, Wang Q, ''et al.'' |title=Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells. |journal=Tissue Antigens |volume=69 |issue= 2 |pages= 145-53 |year= 2007 |pmid= 17257317 |doi= 10.1111/j.1399-0039.2006.00710.x }}
}}
}}
{{refend}}
{{refend}}
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==External links==
==External links==
* {{MeshName|BTLA+protein,+human}}
* {{MeshName|BTLA+protein,+human}}
* {{UCSC gene info|BTLA}}


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{{PDB Gallery|geneid=151888}}
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[[Category:Clusters of differentiation]]
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Revision as of 02:42, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene.[1][2] BTLA has also been designated as CD272 (cluster of differentiation 272).

Function

BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4.[2] However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

Clinical significance

BTLA activation inhibits the function of human CD8+ cancer-specific T cells.[3]

References

  1. ↑ Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (Jun 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nat Immunol. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776.
  2. ↑ 2.0 2.1 "Entrez Gene: BTLA B and T lymphocyte associated".
  3. ↑ Derré L, Rivals J-P, Jandus C, Pastor S, Rimoldi D, Romero P, Michielin O, Olive D, Speiser DE (2009). "BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination". J Clin Invest. 120 (1): 157–67. doi:10.1172/JCI40070. PMC 2799219. PMID 20038811. Lay summary – Genetic Engineering & Biotechnology News.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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