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{{Infobox_gene}}
{{PBB_Controls
'''NKG2-C type II integral membrane protein''' is a [[protein]] that in humans is encoded by the ''KLRC2'' [[gene]].<ref name="pmid9598306">{{cite journal | vauthors = Plougastel B, Trowsdale J | title = Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes | journal = Genomics | volume = 49 | issue = 2 | pages = 193–9 | date = Apr 1998 | pmid = 9598306 | pmc = | doi = 10.1006/geno.1997.5197 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3822| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Killer cell lectin-like receptor subfamily C, member 2
| HGNCid = 6375
| Symbol = KLRC2
| AltSymbols =; CD159c; MGC138244; NKG2-C; NKG2C
| OMIM = 602891
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_KLRC2_206785_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3822
    | Hs_Ensembl = ENSG00000205809
    | Hs_RefseqProtein = NP_002251
    | Hs_RefseqmRNA = NM_002260
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 10474477
    | Hs_GenLoc_end = 10479859
    | Hs_Uniprot = P26717
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Killer cell lectin-like receptor subfamily C, member 2''', also known as '''KLRC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3822| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3822| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
KLRC2 has been shown to [[Protein-protein interaction|interact]] with [[KLRD1]].<ref name=pmid8943374>{{cite journal | vauthors = Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH | title = Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits | journal = Journal of Immunology | volume = 157 | issue = 11 | pages = 4741–5 | date = Dec 1996 | pmid = 8943374 }}</ref><ref name=pmid10320637>{{cite journal | vauthors = Ding Y, Sumitran S, Holgersson J | title = Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells | journal = Scandinavian Journal of Immunology | volume = 49 | issue = 5 | pages = 459–65 | date = May 1999 | pmid = 10320637 | doi = 10.1046/j.1365-3083.1999.00566.x }}</ref>
The binding of this CD94/NKG2C heterodimer to its cellular ligand HLA-E has been shown to drive the expansion of a subset of Natural Killer (NK) cells in response to viral infections.<ref>{{cite journal | vauthors = Rölle A, Pollmann J, Ewen EM, Le VT, Halenius A, Hengel H, Cerwenka A | title = IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion | journal = The Journal of Clinical Investigation | volume = 124 | issue = 12 | pages = 5305–16 | date = Dec 2014 | pmid = 25384219 | doi = 10.1172/JCI77440 | pmc=4348979}}</ref>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Houchins JP, Yabe T, McSherry C, Bach FH | title = DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells | journal = The Journal of Experimental Medicine | volume = 173 | issue = 4 | pages = 1017–20 | date = Apr 1991 | pmid = 2007850 | pmc = 2190798 | doi = 10.1084/jem.173.4.1017 }}
| citations =
* {{cite journal | vauthors = Yabe T, McSherry C, Bach FH, Fisch P, Schall RP, Sondel PM, Houchins JP | title = A multigene family on human chromosome 12 encodes natural killer-cell lectins | journal = Immunogenetics | volume = 37 | issue = 6 | pages = 455–60 | year = 1993 | pmid = 8436421 | doi = 10.1007/BF00222470 }}
*{{cite journal | author=Houchins JP, Yabe T, McSherry C, Bach FH |title=DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. |journal=J. Exp. Med. |volume=173 |issue= 4 |pages= 1017-20 |year= 1991 |pmid= 2007850 |doi= }}
* {{cite journal | vauthors = Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC | title = Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C | journal = Journal of Immunology | volume = 158 | issue = 8 | pages = 3603–9 | date = Apr 1997 | pmid = 9103421 | doi =  }}
*{{cite journal | author=Yabe T, McSherry C, Bach FH, ''et al.'' |title=A multigene family on human chromosome 12 encodes natural killer-cell lectins. |journal=Immunogenetics |volume=37 |issue= 6 |pages= 455-60 |year= 1993 |pmid= 8436421 |doi= }}
* {{cite journal | vauthors = Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ | title = HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C | journal = Nature | volume = 391 | issue = 6669 | pages = 795–9 | date = Feb 1998 | pmid = 9486650 | doi = 10.1038/35869 }}
*{{cite journal | author=Houchins JP, Lanier LL, Niemi EC, ''et al.'' |title=Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. |journal=J. Immunol. |volume=158 |issue= 8 |pages= 3603-9 |year= 1997 |pmid= 9103421 |doi=  }}
* {{cite journal | vauthors = Lanier LL, Corliss B, Wu J, Phillips JH | title = Association of DAP12 with activating CD94/NKG2C NK cell receptors | journal = Immunity | volume = 8 | issue = 6 | pages = 693–701 | date = Jun 1998 | pmid = 9655483 | doi = 10.1016/S1074-7613(00)80574-9 }}
*{{cite journal | author=Braud VM, Allan DS, O'Callaghan CA, ''et al.'' |title=HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. |journal=Nature |volume=391 |issue= 6669 |pages= 795-9 |year= 1998 |pmid= 9486650 |doi= 10.1038/35869 }}
* {{cite journal | vauthors = Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F | title = The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex | journal = Immunogenetics | volume = 48 | issue = 3 | pages = 163–73 | date = Aug 1998 | pmid = 9683661 | doi = 10.1007/s002510050420 }}
*{{cite journal | author=Plougastel B, Trowsdale J |title=Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes. |journal=Genomics |volume=49 |issue= 2 |pages= 193-9 |year= 1998 |pmid= 9598306 |doi= 10.1006/geno.1997.5197 }}
* {{cite journal | vauthors = Ding Y, Sumitran S, Holgersson J | title = Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells | journal = Scandinavian Journal of Immunology | volume = 49 | issue = 5 | pages = 459–65 | date = May 1999 | pmid = 10320637 | doi = 10.1046/j.1365-3083.1999.00566.x }}
*{{cite journal  | author=Lanier LL, Corliss B, Wu J, Phillips JH |title=Association of DAP12 with activating CD94/NKG2C NK cell receptors. |journal=Immunity |volume=8 |issue= 6 |pages= 693-701 |year= 1998 |pmid= 9655483 |doi= }}
* {{cite journal | vauthors = Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P | title = Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans | journal = Immunity | volume = 12 | issue = 6 | pages = 687–98 | date = Jun 2000 | pmid = 10894168 | doi = 10.1016/S1074-7613(00)80219-8 }}
*{{cite journal | author=Glienke J, Sobanov Y, Brostjan C, ''et al.'' |title=The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex. |journal=Immunogenetics |volume=48 |issue= 3 |pages= 163-73 |year= 1998 |pmid= 9683661 |doi= }}
* {{cite journal | vauthors = Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P | title = Conservation and variation in human and common chimpanzee CD94 and NKG2 genes | journal = Journal of Immunology | volume = 168 | issue = 1 | pages = 240–52 | date = Jan 2002 | pmid = 11751968 | doi = 10.4049/jimmunol.168.1.240 }}
*{{cite journal | author=Ding Y, Sumitran S, Holgersson J |title=Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells. |journal=Scand. J. Immunol. |volume=49 |issue= 5 |pages= 459-65 |year= 1999 |pmid= 10320637 |doi= }}
* {{cite journal | vauthors = Hikami K, Tsuchiya N, Yabe T, Tokunaga K | title = Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population | journal = Genes and Immunity | volume = 4 | issue = 2 | pages = 160–7 | date = Mar 2003 | pmid = 12618865 | doi = 10.1038/sj.gene.6363940 }}
*{{cite journal | author=Khakoo SI, Rajalingam R, Shum BP, ''et al.'' |title=Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. |journal=Immunity |volume=12 |issue= 6 |pages= 687-98 |year= 2000 |pmid= 10894168 |doi= }}
* {{cite journal | vauthors = Miyashita R, Tsuchiya N, Hikami K, Kuroki K, Fukazawa T, Bijl M, Kallenberg CG, Hashimoto H, Yabe T, Tokunaga K | title = Molecular genetic analyses of human NKG2C (KLRC2) gene deletion | journal = International Immunology | volume = 16 | issue = 1 | pages = 163–8 | date = Jan 2004 | pmid = 14688071 | doi = 10.1093/intimm/dxh013 }}
*{{cite journal | author=Shum BP, Flodin LR, Muir DG, ''et al.'' |title=Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 240-52 |year= 2002 |pmid= 11751968 |doi= }}
* {{cite journal | vauthors = Ortega C, Romero P, Palma A, Orta T, Peña J, García-Vinuesa A, Molina IJ, Santamaría M | title = Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses | journal = Immunology and Cell Biology | volume = 82 | issue = 6 | pages = 587–95 | date = Dec 2004 | pmid = 15550116 | doi = 10.1111/j.0818-9641.2004.01284.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Gumá M, Busch LK, Salazar-Fontana LI, Bellosillo B, Morte C, García P, López-Botet M | title = The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells | journal = European Journal of Immunology | volume = 35 | issue = 7 | pages = 2071–80 | date = Jul 2005 | pmid = 15940674 | doi = 10.1002/eji.200425843 }}
*{{cite journal | author=Hikami K, Tsuchiya N, Yabe T, Tokunaga K |title=Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. |journal=Genes Immun. |volume=4 |issue= 2 |pages= 160-7 |year= 2003 |pmid= 12618865 |doi= 10.1038/sj.gene.6363940 }}
*{{cite journal | author=Miyashita R, Tsuchiya N, Hikami K, ''et al.'' |title=Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. |journal=Int. Immunol. |volume=16 |issue= 1 |pages= 163-8 |year= 2004 |pmid= 14688071 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Ortega C, Romero P, Palma A, ''et al.'' |title=Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses. |journal=Immunol. Cell Biol. |volume=82 |issue= 6 |pages= 587-95 |year= 2005 |pmid= 15550116 |doi= 10.1111/j.0818-9641.2004.01284.x }}
*{{cite journal | author=Gumá M, Busch LK, Salazar-Fontana LI, ''et al.'' |title=The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells. |journal=Eur. J. Immunol. |volume=35 |issue= 7 |pages= 2071-80 |year= 2005 |pmid= 15940674 |doi= 10.1002/eji.200425843 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Revision as of 02:18, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene.[1][2]

Function

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.[2]

Interactions

KLRC2 has been shown to interact with KLRD1.[3][4] The binding of this CD94/NKG2C heterodimer to its cellular ligand HLA-E has been shown to drive the expansion of a subset of Natural Killer (NK) cells in response to viral infections.[5]

See also

References

  1. ↑ Plougastel B, Trowsdale J (Apr 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306.
  2. ↑ 2.0 2.1 "Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2".
  3. ↑ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology. 157 (11): 4741–5. PMID 8943374.
  4. ↑ Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.
  5. ↑ Rölle A, Pollmann J, Ewen EM, Le VT, Halenius A, Hengel H, Cerwenka A (Dec 2014). "IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion". The Journal of Clinical Investigation. 124 (12): 5305–16. doi:10.1172/JCI77440. PMC 4348979. PMID 25384219.

Further reading

  • Houchins JP, Yabe T, McSherry C, Bach FH (Apr 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". The Journal of Experimental Medicine. 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850.
  • Yabe T, McSherry C, Bach FH, Fisch P, Schall RP, Sondel PM, Houchins JP (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins". Immunogenetics. 37 (6): 455–60. doi:10.1007/BF00222470. PMID 8436421.
  • Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC (Apr 1997). "Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C". Journal of Immunology. 158 (8): 3603–9. PMID 9103421.
  • Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ (Feb 1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795–9. doi:10.1038/35869. PMID 9486650.
  • Lanier LL, Corliss B, Wu J, Phillips JH (Jun 1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity. 8 (6): 693–701. doi:10.1016/S1074-7613(00)80574-9. PMID 9655483.
  • Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F (Aug 1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics. 48 (3): 163–73. doi:10.1007/s002510050420. PMID 9683661.
  • Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology. 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.
  • Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P (Jun 2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans". Immunity. 12 (6): 687–98. doi:10.1016/S1074-7613(00)80219-8. PMID 10894168.
  • Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P (Jan 2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". Journal of Immunology. 168 (1): 240–52. doi:10.4049/jimmunol.168.1.240. PMID 11751968.
  • Hikami K, Tsuchiya N, Yabe T, Tokunaga K (Mar 2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population". Genes and Immunity. 4 (2): 160–7. doi:10.1038/sj.gene.6363940. PMID 12618865.
  • Miyashita R, Tsuchiya N, Hikami K, Kuroki K, Fukazawa T, Bijl M, Kallenberg CG, Hashimoto H, Yabe T, Tokunaga K (Jan 2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion". International Immunology. 16 (1): 163–8. doi:10.1093/intimm/dxh013. PMID 14688071.
  • Ortega C, Romero P, Palma A, Orta T, Peña J, García-Vinuesa A, Molina IJ, Santamaría M (Dec 2004). "Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses". Immunology and Cell Biology. 82 (6): 587–95. doi:10.1111/j.0818-9641.2004.01284.x. PMID 15550116.
  • Gumá M, Busch LK, Salazar-Fontana LI, Bellosillo B, Morte C, García P, López-Botet M (Jul 2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells". European Journal of Immunology. 35 (7): 2071–80. doi:10.1002/eji.200425843. PMID 15940674.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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