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{{Infobox_gene}}
{{PBB_Controls
'''CD7''' ('''C'''luster of '''D'''ifferentiation 7) is a [[protein]] that in humans is encoded by the ''CD7'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD7 CD7 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=924| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
This gene encodes a transmembrane protein which is a member of the [[immunoglobulin]] superfamily. This protein is found on [[thymocyte]]s and mature [[T cell]]s. It plays an essential role in T-cell interactions and also in [[T-cell]]/[[B-cell]] interaction during early [[lymphoid]] development.<ref name="entrez"/>
| image = 
| image_source = 
| PDB =
| Name = CD7 molecule
| HGNCid = 1695
| Symbol = CD7
| AltSymbols =; GP40; LEU-9; TP41; Tp40
| OMIM = 186820
| ECnumber = 
| Homologene = 4471
| MGIid = 88344
| GeneAtlas_image1 = PBB_GE_CD7_214551_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD7_214049_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0042110 |text = T cell activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 924
    | Hs_Ensembl = ENSG00000173762
    | Hs_RefseqProtein = NP_006128
    | Hs_RefseqmRNA = NM_006137
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77866035
    | Hs_GenLoc_end = 77868769
    | Hs_Uniprot = P09564
    | Mm_EntrezGene = 12516
    | Mm_Ensembl = ENSMUSG00000025163
    | Mm_RefseqmRNA = NM_009854
    | Mm_RefseqProtein = NP_033984
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120852841
    | Mm_GenLoc_end = 120855508
    | Mm_Uniprot = Q3U4A8
  }}
}}
'''CD7''' ('''C'''luster of '''D'''ifferentiation 7) is a human [[protein]] encoded by the {{gene|CD7}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD7 CD7 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=924| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
* [[Cluster of differentiation]]
| section_title =  
| summary_text = This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.<ref name="entrez">{{cite web | title = Entrez Gene: CD7 CD7 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=924| accessdate = }}</ref>
}}


==See also==
== Interactions ==
* [[Cluster of differentiation]]
CD7 has been shown to [[Protein-protein interaction|interact]] with [[PIK3R1]].<ref name=pmid8918688>{{cite journal | vauthors = Lee DM, Patel DD, Pendergast AM, Haynes BF | title = Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif | journal = International Immunology | volume = 8 | issue = 8 | pages = 1195–203 | date = August 1996 | pmid = 8918688 | doi = 10.1093/intimm/8.8.1195 }}</ref><ref name=pmid12594831>{{cite journal | vauthors = Subrahmanyam G, Rudd CE, Schneider H | title = Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover | journal = European Journal of Immunology | volume = 33 | issue = 1 | pages = 46–52 | date = January 2003 | pmid = 12594831 | doi = 10.1002/immu.200390006 }}</ref>
 
== Clinical significance ==
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.<ref name="Ogata_2012">{{cite journal | vauthors = Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F | title = Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study | journal = Leukemia Research | volume = 36 | issue = 10 | pages = 1229–36 | date = October 2012 | pmid = 22682984 | doi = 10.1016/j.leukres.2012.05.006 }}</ref> Also, a lack of CD7 expression could insinuate [[mycosis fungoides]] (MF) or [[Sezary syndrome]] (SS).<ref name="pmid12374541">{{cite journal | vauthors = Stevens SR, Baron ED, Masten S, Cooper KD | title = Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis | journal = Archives of Dermatology | volume = 138 | issue = 10 | pages = 1347–50 | date = October 2002 | pmid = 12374541 | doi = 10.1001/archderm.138.10.1347 }}</ref>


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stillwell R, Bierer BE | title = T cell signal transduction and the role of CD7 in costimulation | journal = Immunologic Research | volume = 24 | issue = 1 | pages = 31–52 | year = 2002 | pmid = 11485208 | doi = 10.1385/IR:24:1:31 }}
| citations =
* {{cite journal | vauthors = Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM | title = Localization of the cell surface antigen CD7 by chromosomal in situ hybridization | journal = Immunogenetics | volume = 31 | issue = 5-6 | pages = 412–3 | year = 1990 | pmid = 1695199 | doi = 10.1007/BF02115022 }}
*{{cite journal | author=Stillwell R, Bierer BE |title=T cell signal transduction and the role of CD7 in costimulation. |journal=Immunol. Res. |volume=24 |issue= 1 |pages= 31-52 |year= 2002 |pmid= 11485208 |doi= }}
* {{cite journal | vauthors = Schanberg LE, Fleenor DE, Kurtzberg J, Haynes BF, Kaufman RE | title = Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 2 | pages = 603–7 | date = January 1991 | pmid = 1703303 | pmc = 50860 | doi = 10.1073/pnas.88.2.603 }}
*{{cite journal | author=Baker E, Sandrin MS, Garson OM, ''et al.'' |title=Localization of the cell surface antigen CD7 by chromosomal in situ hybridization. |journal=Immunogenetics |volume=31 |issue= 5-6 |pages= 412-3 |year= 1990 |pmid= 1695199 |doi= }}
* {{cite journal | vauthors = Yoshikawa K, Seto M, Ueda R, Obata Y, Notake K, Yokochi T, Takahashi T | title = Molecular cloning of the gene coding for the human T cell differentiation antigen CD7 | journal = Immunogenetics | volume = 33 | issue = 5-6 | pages = 352–60 | year = 1991 | pmid = 1711009 | doi = 10.1007/BF00216694 }}
*{{cite journal | author=Schanberg LE, Fleenor DE, Kurtzberg J, ''et al.'' |title=Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 2 |pages= 603-7 |year= 1991 |pmid= 1703303 |doi= }}
* {{cite journal | vauthors = Ware RE, Scearce RM, Dietz MA, Starmer CF, Palker TJ, Haynes BF | title = Characterization of the surface topography and putative tertiary structure of the human CD7 molecule | journal = Journal of Immunology | volume = 143 | issue = 11 | pages = 3632–40 | date = December 1989 | pmid = 2479685 | doi =  }}
*{{cite journal | author=Yoshikawa K, Seto M, Ueda R, ''et al.'' |title=Molecular cloning of the gene coding for the human T cell differentiation antigen CD7. |journal=Immunogenetics |volume=33 |issue= 5-6 |pages= 352-60 |year= 1991 |pmid= 1711009 |doi= }}
* {{cite journal | vauthors = Osada S, Utsumi KR, Ueda R, Akao Y, Tsuge I, Nishida K, Okada J, Matsuoka H, Takahashi T | title = Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17 | journal = Cytogenetics and Cell Genetics | volume = 47 | issue = 1-2 | pages = 8–10 | year = 1988 | pmid = 3258561 | doi = 10.1159/000132494 }}
*{{cite journal | author=Ware RE, Scearce RM, Dietz MA, ''et al.'' |title=Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. |journal=J. Immunol. |volume=143 |issue= 11 |pages= 3632-40 |year= 1990 |pmid= 2479685 |doi=  }}
* {{cite journal | vauthors = Aruffo A, Seed B | title = Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system | journal = The EMBO Journal | volume = 6 | issue = 11 | pages = 3313–6 | date = November 1987 | pmid = 3501369 | pmc = 553785 | doi =  }}
*{{cite journal | author=Osada S, Utsumi KR, Ueda R, ''et al.'' |title=Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17. |journal=Cytogenet. Cell Genet. |volume=47 |issue= 1-2 |pages= 8-10 |year= 1988 |pmid= 3258561 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Aruffo A, Seed B |title=Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. |journal=EMBO J. |volume=6 |issue= 11 |pages= 3313-6 |year= 1988 |pmid= 3501369 |doi=  }}
* {{cite journal | vauthors = Lee DM, Schanberg LE, Fleenor DE, Seldin MF, Haynes BF, Kaufman RE | title = The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters | journal = Immunogenetics | volume = 44 | issue = 2 | pages = 108–14 | year = 1996 | pmid = 8662072 | doi = 10.1007/s002510050097 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Bevec T, Stoka V, Pungercic G, Dolenc I, Turk V | title = Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L | journal = The Journal of Experimental Medicine | volume = 183 | issue = 4 | pages = 1331–8 | date = April 1996 | pmid = 8666891 | pmc = 2192513 | doi = 10.1084/jem.183.4.1331 }}
*{{cite journal | author=Lee DM, Schanberg LE, Fleenor DE, ''et al.'' |title=The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters. |journal=Immunogenetics |volume=44 |issue= 2 |pages= 108-14 |year= 1996 |pmid= 8662072 |doi= }}
* {{cite journal | vauthors = Leta E, Hou Z, Lederman L, Jung LK | title = Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7 | journal = Cellular Immunology | volume = 173 | issue = 1 | pages = 15–21 | date = October 1996 | pmid = 8871597 | doi = 10.1006/cimm.1996.0247 }}
*{{cite journal | author=Bevec T, Stoka V, Pungercic G, ''et al.'' |title=Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1331-8 |year= 1996 |pmid= 8666891 |doi= }}
* {{cite journal | vauthors = Lee DM, Patel DD, Pendergast AM, Haynes BF | title = Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif | journal = International Immunology | volume = 8 | issue = 8 | pages = 1195–203 | date = August 1996 | pmid = 8918688 | doi = 10.1093/intimm/8.8.1195 }}
*{{cite journal | author=Leta E, Hou Z, Lederman L, Jung LK |title=Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7. |journal=Cell. Immunol. |volume=173 |issue= 1 |pages= 15-21 |year= 1996 |pmid= 8871597 |doi= 10.1006/cimm.1996.0247 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Lee DM, Patel DD, Pendergast AM, Haynes BF |title=Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. |journal=Int. Immunol. |volume=8 |issue= 8 |pages= 1195-203 |year= 1997 |pmid= 8918688 |doi= }}
* {{cite journal | vauthors = Slentz-Kesler KA, Hale LP, Kaufman RE | title = Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms | journal = Genomics | volume = 47 | issue = 3 | pages = 327–40 | date = February 1998 | pmid = 9480746 | doi = 10.1006/geno.1997.5151 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34171–9 | date = December 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171 }}
*{{cite journal | author=Slentz-Kesler KA, Hale LP, Kaufman RE |title=Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. |journal=Genomics |volume=47 |issue= 3 |pages= 327-40 |year= 1998 |pmid= 9480746 |doi= 10.1006/geno.1997.5151 }}
* {{cite journal | vauthors = Pace KE, Lee C, Stewart PL, Baum LG | title = Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1 | journal = Journal of Immunology | volume = 163 | issue = 7 | pages = 3801–11 | date = October 1999 | pmid = 10490978 | doi =  }}
*{{cite journal | author=Steegmaier M, Yang B, Yoo JS, ''et al.'' |title=Three novel proteins of the syntaxin/SNAP-25 family. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34171-9 |year= 1999 |pmid= 9852078 |doi= }}
* {{cite journal | vauthors = Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC | title = Identification of CD7 as a cognate of the human K12 (SECTM1) protein | journal = The Journal of Biological Chemistry | volume = 275 | issue = 5 | pages = 3431–7 | date = February 2000 | pmid = 10652336 | doi = 10.1074/jbc.275.5.3431 }}
*{{cite journal | author=Pace KE, Lee C, Stewart PL, Baum LG |title=Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. |journal=J. Immunol. |volume=163 |issue= 7 |pages= 3801-11 |year= 1999 |pmid= 10490978 |doi=  }}
* {{cite journal | vauthors = Rotem-Yehudar R, Galperin E, Horowitz M | title = Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33054–60 | date = August 2001 | pmid = 11423532 | doi = 10.1074/jbc.M009913200 }}
*{{cite journal | author=Lyman SD, Escobar S, Rousseau AM, ''et al.'' |title=Identification of CD7 as a cognate of the human K12 (SECTM1) protein. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3431-7 |year= 2000 |pmid= 10652336 |doi= }}
* {{cite journal | vauthors = Rossi MI, Yokota T, Medina KL, Garrett KP, Comp PC, Schipul AH, Kincade PW | title = B lymphopoiesis is active throughout human life, but there are developmental age-related changes | journal = Blood | volume = 101 | issue = 2 | pages = 576–84 | date = January 2003 | pmid = 12393702 | doi = 10.1182/blood-2002-03-0896 }}
*{{cite journal | author=Rotem-Yehudar R, Galperin E, Horowitz M |title=Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33054-60 |year= 2001 |pmid= 11423532 |doi= 10.1074/jbc.M009913200 }}
*{{cite journal  | author=Rossi MI, Yokota T, Medina KL, ''et al.'' |title=B lymphopoiesis is active throughout human life, but there are developmental age-related changes. |journal=Blood |volume=101 |issue= 2 |pages= 576-84 |year= 2003 |pmid= 12393702 |doi= 10.1182/blood-2002-03-0896 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CD7+protein,+human}}
*{{MeshName|CD7+protein,+human}}
* {{UCSC gene info|CD7}}


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Clusters of differentiation by lineage}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]


[[es:CD7]]
{{membrane-protein-stub}}
{{WikiDoc Sources}}

Revision as of 02:01, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[1]

Function

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]

See also

Interactions

CD7 has been shown to interact with PIK3R1.[2][3]

Clinical significance

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[4] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CD7 CD7 molecule".
  2. ↑ Lee DM, Patel DD, Pendergast AM, Haynes BF (August 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". International Immunology. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
  3. ↑ Subrahmanyam G, Rudd CE, Schneider H (January 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". European Journal of Immunology. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831.
  4. ↑ Ogata K, Kakumoto K, Matsuda A, Tohyama K, Tamura H, Ueda Y, Kurokawa M, Takeuchi J, Shibayama H, Emi N, Motoji T, Miyazaki Y, Tamaki H, Mitani K, Naoe T, Sugiyama H, Takaku F (October 2012). "Differences in blast immunophenotypes among disease types in myelodysplastic syndromes: a multicenter validation study". Leukemia Research. 36 (10): 1229–36. doi:10.1016/j.leukres.2012.05.006. PMID 22682984.
  5. ↑ Stevens SR, Baron ED, Masten S, Cooper KD (October 2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Archives of Dermatology. 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541.

Further reading

External links

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