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{{Infobox_gene}}
{{PBB_Controls
'''Sialic acid-binding Ig-like lectin 7''' is a [[protein]] that in humans is encoded by the ''SIGLEC7'' [[gene]].<ref name="pmid10567377">{{cite journal | vauthors = Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, Mattei MG, Crocker PR | title = Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes | journal = J Biol Chem | volume = 274 | issue = 48 | pages = 34089–95 |date=Dec 1999 | pmid = 10567377 | pmc =  | doi =10.1074/jbc.274.48.34089 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27036| accessdate = }}</ref> SIGLEC7 has also been designated as '''CD328''' ([[cluster of differentiation]] 328).
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{{GNF_Protein_box
| image = PBB_Protein_SIGLEC7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nko.
| PDB = {{PDB2|1nko}}, {{PDB2|1o7s}}, {{PDB2|1o7v}}, {{PDB2|2df3}}, {{PDB2|2g5r}}, {{PDB2|2hrl}}
| Name = Sialic acid binding Ig-like lectin 7
| HGNCid = 10876
| Symbol = SIGLEC7
| AltSymbols =; p75; AIRM1; CDw328; D-siglec; QA79; SIGLEC-7; p75/AIRM1
| OMIM = 604410
| ECnumber =
| Homologene = 88828
| MGIid = 1932475
  | GeneAtlas_image1 = PBB_GE_SIGLEC7_207224_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SIGLEC7_216537_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SIGLEC7_217159_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
  | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27036
    | Hs_Ensembl = ENSG00000168995
    | Hs_RefseqProtein = NP_055200
    | Hs_RefseqmRNA = NM_014385
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 56337376
    | Hs_GenLoc_end = 56348595
    | Hs_Uniprot = Q9Y286
    | Mm_EntrezGene = 83382
    | Mm_Ensembl = ENSMUSG00000030474
    | Mm_RefseqmRNA = NM_031181
    | Mm_RefseqProtein = NP_112458
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 43519132
    | Mm_GenLoc_end = 43528199
    | Mm_Uniprot = Q6PJ50
  }}
}}
'''Sialic acid binding Ig-like lectin 7''', also known as '''SIGLEC7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27036| accessdate = }}</ref> SIGLEC7 has also been designated as '''CD328''' ([[cluster of differentiation]] 328).


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Reif K, Buday L, Downward J, Cantrell DA |title=SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14081-7 |year= 1994 |pmid= 8188688 |doi=  }}
*{{cite journal  | vauthors=Reif K, Buday L, Downward J, Cantrell DA |title=SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 14081–7 |year= 1994 |pmid= 8188688 |doi=  }}
*{{cite journal | author=Falco M, Biassoni R, Bottino C, ''et al.'' |title=Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. |journal=J. Exp. Med. |volume=190 |issue= 6 |pages= 793-802 |year= 1999 |pmid= 10499918 |doi=  }}
*{{cite journal   |vauthors=Falco M, Biassoni R, Bottino C, etal |title=Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. |journal=J. Exp. Med. |volume=190 |issue= 6 |pages= 793–802 |year= 1999 |pmid= 10499918 |doi=10.1084/jem.190.6.793  | pmc=2195632 }}
*{{cite journal | author=Ye X, Mehlen P, Rabizadeh S, ''et al.'' |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202-8 |year= 1999 |pmid= 10514511 |doi= }}
*{{cite journal   |vauthors=Ye X, Mehlen P, Rabizadeh S, etal |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202–8 |year= 1999 |pmid= 10514511 |doi=10.1074/jbc.274.42.30202  }}
*{{cite journal | author=Nicoll G, Ni J, Liu D, ''et al.'' |title=Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34089-95 |year= 1999 |pmid= 10567377 |doi= }}
*{{cite journal   |vauthors=Vitale C, Romagnani C, Falco M, etal |title=Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 15091–6 |year= 2000 |pmid= 10611343 |doi=10.1073/pnas.96.26.15091  | pmc=24778  }}
*{{cite journal  | author=Vitale C, Romagnani C, Falco M, ''et al.'' |title=Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 15091-6 |year= 2000 |pmid= 10611343 |doi= }}
*{{cite journal  | vauthors=Angata T, Varki A |title=Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. |journal=Glycobiology |volume=10 |issue= 4 |pages= 431–8 |year= 2000 |pmid= 10764831 |doi=10.1093/glycob/10.4.431  }}
*{{cite journal | author=Angata T, Varki A |title=Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. |journal=Glycobiology |volume=10 |issue= 4 |pages= 431-8 |year= 2000 |pmid= 10764831 |doi=  }}
*{{cite journal   |vauthors=Ito A, Handa K, Withers DA, etal |title=Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 116–20 |year= 2001 |pmid= 11389909 |doi=10.1016/S0014-5793(01)02476-0 }}
*{{cite journal | author=Ito A, Handa K, Withers DA, ''et al.'' |title=Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 116-20 |year= 2001 |pmid= 11389909 |doi=  }}
*{{cite journal   |vauthors=Mingari MC, Vitale C, Romagnani C, etal |title=Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. |journal=Adv. Exp. Med. Biol. |volume=495 |issue= |pages= 55–61 |year= 2002 |pmid= 11774609 |doi=  10.1007/978-1-4615-0685-0_8}}
*{{cite journal  | author=Mingari MC, Vitale C, Romagnani C, ''et al.'' |title=Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors. |journal=Adv. Exp. Med. Biol. |volume=495 |issue= |pages= 55-61 |year= 2002 |pmid= 11774609 |doi= }}
*{{cite journal  | vauthors=Yousef GM, Ordon MH, Foussias G, Diamandis EP |title=Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. |journal=Gene |volume=286 |issue= 2 |pages= 259–70 |year= 2002 |pmid= 11943481 |doi=10.1016/S0378-1119(02)00432-8  }}
*{{cite journal  | author=Yousef GM, Ordon MH, Foussias G, Diamandis EP |title=Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. |journal=Gene |volume=286 |issue= 2 |pages= 259-70 |year= 2002 |pmid= 11943481 |doi= }}
*{{cite journal  | vauthors=Alphey MS, Attrill H, Crocker PR, van Aalten DM |title=High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3372–7 |year= 2003 |pmid= 12438315 |doi= 10.1074/jbc.M210602200 }}
*{{cite journal | author=Alphey MS, Attrill H, Crocker PR, van Aalten DM |title=High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3372-7 |year= 2003 |pmid= 12438315 |doi= 10.1074/jbc.M210602200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nicoll G, Avril T, Lock K, etal |title=Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. |journal=Eur. J. Immunol. |volume=33 |issue= 6 |pages= 1642–8 |year= 2003 |pmid= 12778482 |doi= 10.1002/eji.200323693 }}
*{{cite journal | author=Nicoll G, Avril T, Lock K, ''et al.'' |title=Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. |journal=Eur. J. Immunol. |volume=33 |issue= 6 |pages= 1642-8 |year= 2003 |pmid= 12778482 |doi= 10.1002/eji.200323693 }}
*{{cite journal   |vauthors=Dimasi N, Moretta A, Moretta L, etal |title=Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. |journal=Acta Crystallogr. D |volume=60 |issue= Pt 2 |pages= 401–3 |year= 2004 |pmid= 14747738 |doi= 10.1107/S0907444903028439 }}
*{{cite journal  | author=Dimasi N, Moretta A, Moretta L, ''et al.'' |title=Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=60 |issue= Pt 2 |pages= 401-3 |year= 2004 |pmid= 14747738 |doi= 10.1107/S0907444903028439 }}
*{{cite journal  | vauthors=Ikehara Y, Ikehara SK, Paulson JC |title=Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43117–25 |year= 2004 |pmid= 15292262 |doi= 10.1074/jbc.M403538200 }}
*{{cite journal | author=Ikehara Y, Ikehara SK, Paulson JC |title=Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 43117-25 |year= 2004 |pmid= 15292262 |doi= 10.1074/jbc.M403538200 }}
*{{cite journal   |vauthors=Avril T, Floyd H, Lopez F, etal |title=The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6841–9 |year= 2005 |pmid= 15557178 |doi= 10.4049/jimmunol.173.11.6841}}
*{{cite journal  | author=Avril T, Floyd H, Lopez F, ''et al.'' |title=The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6841-9 |year= 2005 |pmid= 15557178 |doi= }}
*{{cite journal  | vauthors=Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y |title=Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. |journal=Glycobiology |volume=15 |issue= 7 |pages= 667–76 |year= 2005 |pmid= 15703304 |doi= 10.1093/glycob/cwi048 }}
*{{cite journal | author=Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y |title=Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. |journal=Glycobiology |volume=15 |issue= 7 |pages= 667-76 |year= 2005 |pmid= 15703304 |doi= 10.1093/glycob/cwi048 }}
*{{cite journal   |vauthors=Attrill H, Takazawa H, Witt S, etal |title=The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. |journal=Biochem. J. |volume=397 |issue= 2 |pages= 271–8 |year= 2006 |pmid= 16623661 |doi= 10.1042/BJ20060103  | pmc=1513286 }}
*{{cite journal | author=Attrill H, Takazawa H, Witt S, ''et al.'' |title=The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. |journal=Biochem. J. |volume=397 |issue= 2 |pages= 271-8 |year= 2006 |pmid= 16623661 |doi= 10.1042/BJ20060103 }}
*{{cite journal   |vauthors=Rapoport EM, Pazynina GV, Sablina MA, etal |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496–504 |year= 2006 |pmid= 16732727 |doi=10.1134/S0006297906050051 }}
*{{cite journal  | author=Rapoport EM, Pazynina GV, Sablina MA, ''et al.'' |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496-504 |year= 2006 |pmid= 16732727 |doi= }}
*{{cite journal  | vauthors=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211–20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
*{{cite journal  | author=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211-20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=27036}}


==External links==
==External links==
* {{MeshName|SIGLEC7+protein,+human}}
* {{MeshName|SIGLEC7+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:21, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene.[1][2] SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).


References

  1. ↑ Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, Mattei MG, Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem. 274 (48): 34089–95. doi:10.1074/jbc.274.48.34089. PMID 10567377.
  2. ↑ "Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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